Corrigendum: Impact of a TAK-1 inhibitor as a single or as an add-on therapy to riociguat on the metabolic reprograming and pulmonary hypertension in the SUGEN5416/hypoxia rat model

In the published article, there was an error in Figure 2 as published. There was a mistake in the identification of two of the panels (B and C) which were described respectively as “(B) systolic PAP (sPAP) and (C) diastolic PAP (dPAP).” The corrected Figure 2, and it is caption, appear below.

FIGURE 2.

Treatment with riociguat alone or combined with 5-z-7oxozeaenol attenuates pulmonary hypertension in the Sugen 5426/hypoxia (SuHyp) rat model. (A) Mean pulmonary arterial pressure (mPAP), (B) diastolic PAP (dPAP) and (C) systolic PAP (sPAP) in control (NMX-Vh) and SuHyp rats treated with vehicle, 5Z-7-oxozeaenol (SuHyp-OXO; 3 mg·kg⁻¹·day⁻¹), riociguat (SuHyp-RIO; 3 mg·kg⁻¹·day⁻¹) or both drugs combined (SuHyp-OXO-RIO). (D) Representative PAP recordings in each treatment group. (E) Right systolic and (F) end-diastolic ventricular pressure (RVSP and RVEDP). (G) Fulton index (ratio between RV and left ventricle plus septum weight) and (H) right ventricular weight relative to total body weight in the different treatment groups. Each bar shows the mean +SEM (n = 6–10 animals in each group). *p < 0.05 versus NMX-Vh and #p < 0,05 versus SuHyp vehicle (One-way ANOVA followed by Bonferroni´s post hoc test).

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

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