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Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1993 Jun;68(6):785–787. doi: 10.1136/adc.68.6.785

Serum interleukin-1 alpha and soluble interleukin-2 receptor concentrations in cystic fibrosis.

P Greally 1, M J Hussain 1, D Vergani 1, J F Price 1
PMCID: PMC1029377  PMID: 8333775

Abstract

Interleukin (IL)-1 and IL-2 may participate in the systemic inflammatory response and hypergammaglobulinaemia observed in patients with cystic fibrosis. Thirty seven patients with cystic fibrosis were compared with 25 normal controls. High IgG and IgM concentrations were associated with more severe pulmonary disease. IL-1 alpha and soluble IL-2 receptor concentrations were higher in the cystic fibrosis group than in the controls and also correlated with concentrations of IgG and IgM. These results suggest that these cytokines may contribute to enhanced immunoglobulin synthesis and silent inflammatory activity in clinically stable patients with cystic fibrosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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