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. 1993 Jul;69(1 Spec No):49–51. doi: 10.1136/adc.69.1_spec_no.49

Bronchoalveolar lavage fluid glutathione in intubated premature infants.

J Grigg 1, A Barber 1, M Silverman 1
PMCID: PMC1029398  PMID: 8346954

Abstract

Lower concentrations of uncorrected glutathione in the bronchoalveolar lavage fluid were found on the first day of life in seven infants who subsequently developed chronic lung disease when compared with 27 infants who did not require supplemental oxygen at 36 weeks' postconceptional age. The concentration of glutathione on the first day was independent of gestational age. These preliminary results suggest that glutathione accumulates in the lung epithelial lining fluid of preterm infants and that a relative deficiency may predispose to lung injury.

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Selected References

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  1. Bancalari E., Sosenko I. Pathogenesis and prevention of neonatal chronic lung disease: recent developments. Pediatr Pulmonol. 1990;8(2):109–116. doi: 10.1002/ppul.1950080209. [DOI] [PubMed] [Google Scholar]
  2. Beutler E., Gelbart T. Plasma glutathione in health and in patients with malignant disease. J Lab Clin Med. 1985 May;105(5):581–584. [PubMed] [Google Scholar]
  3. Cantin A. M., North S. L., Hubbard R. C., Crystal R. G. Normal alveolar epithelial lining fluid contains high levels of glutathione. J Appl Physiol (1985) 1987 Jul;63(1):152–157. doi: 10.1152/jappl.1987.63.1.152. [DOI] [PubMed] [Google Scholar]
  4. Deneke S. M., Lynch B. A., Fanburg B. L. Transient depletion of lung glutathione by diethylmaleate enhances oxygen toxicity. J Appl Physiol (1985) 1985 Feb;58(2):571–574. doi: 10.1152/jappl.1985.58.2.571. [DOI] [PubMed] [Google Scholar]
  5. Edwards D. K., Jacob J., Gluck L. The immature lung: radiographic appearance, course, and complications. AJR Am J Roentgenol. 1980 Oct;135(4):659–666. doi: 10.2214/ajr.135.4.659. [DOI] [PubMed] [Google Scholar]
  6. Fanburg B. L., Deneke S. M. Protein deficiency potentiates oxygen toxicity. Exp Lung Res. 1988;14 (Suppl):911–919. doi: 10.3109/01902148809064183. [DOI] [PubMed] [Google Scholar]
  7. Farber J. L., Kyle M. E., Coleman J. B. Mechanisms of cell injury by activated oxygen species. Lab Invest. 1990 Jun;62(6):670–679. [PubMed] [Google Scholar]
  8. Grigg J. M., Barber A., Silverman M. Increased levels of bronchoalveolar lavage fluid interleukin-6 in preterm ventilated infants after prolonged rupture of membranes. Am Rev Respir Dis. 1992 Apr;145(4 Pt 1):782–786. doi: 10.1164/ajrccm/145.4_Pt_1.782. [DOI] [PubMed] [Google Scholar]
  9. Grigg J., Arnon S., Silverman M. Fractional processing of sequential bronchoalveolar lavage fluid from intubated babies. Eur Respir J. 1992 Jun;5(6):727–732. [PubMed] [Google Scholar]
  10. Hallman M., Merritt T. A., Akino T., Bry K. Surfactant protein A, phosphatidylcholine, and surfactant inhibitors in epithelial lining fluid. Correlation with surface activity, severity of respiratory distress syndrome, and outcome in small premature infants. Am Rev Respir Dis. 1991 Dec;144(6):1376–1384. doi: 10.1164/ajrccm/144.6.1376. [DOI] [PubMed] [Google Scholar]
  11. Jenkinson S. G., Marcum R. F., Pickard J. S., Orzechowski Z., Lawrence R. A., Jordan J. M. Glutathione disulfide formation occurring during hypoxia and reoxygenation of rat lung. J Lab Clin Med. 1988 Oct;112(4):471–480. [PubMed] [Google Scholar]
  12. Pacht E. R., Timerman A. P., Lykens M. G., Merola A. J. Deficiency of alveolar fluid glutathione in patients with sepsis and the adult respiratory distress syndrome. Chest. 1991 Nov;100(5):1397–1403. doi: 10.1378/chest.100.5.1397. [DOI] [PubMed] [Google Scholar]
  13. Picone T. A., Daniels T. A., Ponto K. H., Pittard W. B., 3rd Cord blood tryptophan concentrations and total cysteine concentrations. JPEN J Parenter Enteral Nutr. 1989 Jan-Feb;13(1):106–107. doi: 10.1177/0148607189013001106. [DOI] [PubMed] [Google Scholar]
  14. Smith L. J., Anderson J., Shamsuddin M., Hsueh W. Effect of fasting on hyperoxic lung injury in mice. The role of glutathione. Am Rev Respir Dis. 1990 Jan;141(1):141–149. doi: 10.1164/ajrccm/141.1.141. [DOI] [PubMed] [Google Scholar]
  15. Tee L. B., Boobis A. R., Huggett A. C., Davies D. S. Reversal of acetaminophen toxicity in isolated hamster hepatocytes by dithiothreitol. Toxicol Appl Pharmacol. 1986 Apr;83(2):294–314. doi: 10.1016/0041-008x(86)90307-8. [DOI] [PubMed] [Google Scholar]
  16. Tierney D. F. Lung surfactant: some historical perspectives leading to its cellular and molecular biology. Am J Physiol. 1989 Aug;257(2 Pt 1):L1–12. doi: 10.1152/ajplung.1989.257.2.L1. [DOI] [PubMed] [Google Scholar]

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