Abstract
Using a computerised physiological monitoring system a cyclical variation in blood pressure (waves), with associated changes in heart rate and transcutaneous oxygen, was observed. Twenty five episodes were seen in 10 neonates, with a median gestation of 33 weeks (range 28-42 weeks). Eight neonates had an asphyxial injury. Blood pressure waves had a mean (SD) amplitude of 11.6 (5.6) mm Hg with a mean wavelength of 9.0 (5.2) minutes. Both amplitude and frequency were independent of gestation. In neonates of less than 34 weeks an inverse phase relation existed between heart rate and blood pressure waves (blood pressure rose as heart rate fell); in infants with a gestation greater than 34 weeks a direct phase relationship occurred (blood pressure and heart rate rose together). It is postulated that hypertensive blood pressure waves may cause or exacerbate cerebral pathology in neonates with a pressure passive cerebral circulation.
Full text
PDF



Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Agata Y., Hiraishi S., Oguchi K., Misawa H., Horiguchi Y., Fujino N., Yashiro K., Shimada N. Changes in left ventricular output from fetal to early neonatal life. J Pediatr. 1991 Sep;119(3):441–445. doi: 10.1016/s0022-3476(05)82060-8. [DOI] [PubMed] [Google Scholar]
- Baskett T. F., Ko K. S. Sinusoidal fetal heart pattern. A sign of fetal hypoxia. Obstet Gynecol. 1974 Sep;44(3):379–382. [PubMed] [Google Scholar]
- Bender B. S., Bennett R., Laughon B. E., Greenough W. B., 3rd, Gaydos C., Sears S. D., Forman M. S., Bartlett J. G. Is Clostridium difficile endemic in chronic-care facilities? Lancet. 1986 Jul 5;2(8497):11–13. doi: 10.1016/s0140-6736(86)92559-6. [DOI] [PubMed] [Google Scholar]
- Cunningham S., Deere S., Elton R. A., McIntosh N. Neonatal physiological trend monitoring by computer. Int J Clin Monit Comput. 1992 Dec;9(4):221–227. doi: 10.1007/BF01133617. [DOI] [PubMed] [Google Scholar]
- Hayashi M., Kobayashi H., Handa Y., Kawano H., Kabuto M., Ishii H., Tsuji T. [Systemic blood pressure and respiration during plateau wave phenomena]. No To Shinkei. 1985 Mar;37(3):249–254. [PubMed] [Google Scholar]
- Kocsis B., Fedina L., Pasztor E. Two-phase change of sympathetic rhythms in brain ischemia, Cushing reaction, and asphyxia. Am J Physiol. 1989 Jan;256(1 Pt 2):R120–R132. doi: 10.1152/ajpregu.1989.256.1.R120. [DOI] [PubMed] [Google Scholar]
- Lagercrantz H., Edwards D., Henderson-Smart D., Hertzberg T., Jeffery H. Autonomic reflexes in preterm infants. Acta Paediatr Scand. 1990 Aug-Sep;79(8-9):721–728. doi: 10.1111/j.1651-2227.1990.tb11546.x. [DOI] [PubMed] [Google Scholar]
- Lagercrantz H., Edwards D., Henderson-Smart D., Hertzberg T., Jeffery H. Autonomic reflexes in preterm infants. Acta Paediatr Scand. 1990 Aug-Sep;79(8-9):721–728. doi: 10.1111/j.1651-2227.1990.tb11546.x. [DOI] [PubMed] [Google Scholar]
- Miall-Allen V. M., de Vries L. S., Whitelaw A. G. Mean arterial blood pressure and neonatal cerebral lesions. Arch Dis Child. 1987 Oct;62(10):1068–1069. doi: 10.1136/adc.62.10.1068. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Papile L. A., Burstein J., Burstein R., Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr. 1978 Apr;92(4):529–534. doi: 10.1016/s0022-3476(78)80282-0. [DOI] [PubMed] [Google Scholar]
- Raju T. N., Vidyasagar D., Papazafiratou C. Cerebral perfusion pressure and abnormal intracranial pressure wave forms: their relation to outcome in birth asphyxia. Crit Care Med. 1981 Jun;9(6):449–453. doi: 10.1097/00003246-198106000-00003. [DOI] [PubMed] [Google Scholar]
- Reid M. M., Jenkins J., McClure G. Sinusoidal heart rate rhythms in severe neonatal hypoxia. Arch Dis Child. 1979 Jun;54(6):432–435. doi: 10.1136/adc.54.6.432. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reid M. M., Jenkins J., McClure G. Sinusoidal heart rate rhythms in severe neonatal hypoxia. Arch Dis Child. 1979 Jun;54(6):432–435. doi: 10.1136/adc.54.6.432. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Versmold H. T. Control of blood pressure and the distribution of blood flow. Int J Technol Assess Health Care. 1991;7 (Suppl 1):79–84. doi: 10.1017/s0266462300012551. [DOI] [PubMed] [Google Scholar]
- Waldman S., Krauss A. N., Auld P. A. Baroreceptors in preterm infants: their relationship to maturity and disease. Dev Med Child Neurol. 1979 Dec;21(6):714–722. doi: 10.1111/j.1469-8749.1979.tb01692.x. [DOI] [PubMed] [Google Scholar]
- Winberg P., Ergander U. Relationship between heart rate, left ventricular output, and stroke volume in preterm infants during fluctuations in heart rate. Pediatr Res. 1992 Feb;31(2):117–120. doi: 10.1203/00006450-199202000-00005. [DOI] [PubMed] [Google Scholar]