Abstract
A total of 101 preterm infants between 26 and 37 weeks' gestation who received BCG vaccination at birth were evaluated between two and four months after vaccination. Altogether 32% of these infants had no visible BCG scar. All infants were then tested with tuberculin purified protein derivative (PPD) but only 70 returned for the test to be read 48-72 hours later. The test was negative in 22 (31%) and there was an induration of < or = 5 mm in another 26 (37%) of the infants. Of 22 infants with no BCG scar, 19 (86%) had an induration of < or = 5 mm. In infants with a positive BCG scar a significantly higher number had an induration of PPD > 5 mm. There were no significant differences between the rate of scarring and tuberculin conversion in the infants born before or after 32 weeks' gestation. It is considered that routine BCG vaccination at birth on preterm infants is not indicated until a much larger study has been performed.
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Selected References
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- Curtis H. M., Leck I., Bamford F. N. Incidence of childhood tuberculosis after neonatal BCG vaccination. Lancet. 1984 Jan 21;1(8369):145–148. doi: 10.1016/s0140-6736(84)90072-2. [DOI] [PubMed] [Google Scholar]
- Dawodu A. H. Tuberculin conversion following BCG vaccination in preterm infants. Acta Paediatr Scand. 1985 Jul;74(4):564–567. doi: 10.1111/j.1651-2227.1985.tb11030.x. [DOI] [PubMed] [Google Scholar]
- Dubowitz L. M., Dubowitz V., Goldberg C. Clinical assessment of gestational age in the newborn infant. J Pediatr. 1970 Jul;77(1):1–10. doi: 10.1016/s0022-3476(70)80038-5. [DOI] [PubMed] [Google Scholar]
- Grindulis H., Baynham M. I., Scott P. H., Thompson R. A., Wharton B. A. Tuberculin response two years after BCG vaccination at birth. Arch Dis Child. 1984 Jul;59(7):614–619. doi: 10.1136/adc.59.7.614. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Karalliedde S., Katugaha L. P., Uragoda C. G. Tuberculin response of Sri Lankan children after BCG vaccination at birth. Tubercle. 1987 Mar;68(1):33–38. doi: 10.1016/0041-3879(87)90005-5. [DOI] [PubMed] [Google Scholar]
- Padungchan S., Konjanart S., Kasiratta S., Daramas S., ten Dam H. G. The effectiveness of BCG vaccination of the newborn against childhood tuberculosis in Bangkok. Bull World Health Organ. 1986;64(2):247–258. [PMC free article] [PubMed] [Google Scholar]
- ROSENTHAL S. R., LOEWINSOHNE, GRAHAM M. L., LIVERIGHT D., THORNE G., JOHNSON V. BCG vaccination against tuberculosis in Chicago. A twenty-year study statistically analyzed. Pediatrics. 1961 Oct;28:622–641. [PubMed] [Google Scholar]
- Sedaghatian M. R., Shana'a I. A. Evaluation of BCG at birth in the United Arab Emirates. Tubercle. 1990 Sep;71(3):177–180. doi: 10.1016/0041-3879(90)90072-g. [DOI] [PubMed] [Google Scholar]