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. 2023 Jun 9;12(12):1596. doi: 10.3390/cells12121596

Figure 1.

Figure 1

Schematic representation of Fc−scTNFL proteins. The domain structure of Fc [Hinge containing 2 cysteines, CH2 and CH3 domains], PA peptide tag (GVAMPGAEDDVV), extracellular TNF homology domain (THD) of OX40L (51Ser−198Leu) or 4-1BBL (122Arg−309Glu) or CD70 (45Ser−195Pro) or GITRL (42Thr−173Ser), GGGSGGG peptide linker, extracellular THD of OX40L or 4-1BBL or CD70 or GITRL, GGGSGGG peptide linker, extracellular THD of OX40L or 4-1BBL or CD70 or GITRL and His6 peptide tag (HHHHHH). Nucleotide sequences of Fc−scTNFL proteins are shown in Figure S1.