Abstract
The effect of periconceptional multivitamin supplementation on postnatal development was studied in a randomised controlled trial comparing the use of a multivitamin tablet (Elevit Pronatal) with a tablet containing trace elements as part of the Hungarian Optimal Family Planning Programme. Of 4122 liveborn infants, 3356 were examined after the eighth month of life and medical records were obtained for a further 357; thus the total number of infants evaluated was 3713 (90.1%). The mortality was not significantly different between the groups receiving the multivitamins (9.6/1000) and trace elements (7.1/1000). There was no significant difference in the rates of serious or chronic disorders between the study groups except for atopic dermatitis, which was reported more often in the group receiving multivitamins (15 v four cases). Somatic development (body weight, body length, and head circumference) did not show a significant difference between the two groups. Mental and behavioural development was also similar in the two groups.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Czeizel A. E., Dudas I., Fritz G., Técsöi A., Hanck A., Kunovits G. The effect of periconceptional multivitamin-mineral supplementation on vertigo, nausea and vomiting in the first trimester of pregnancy. Arch Gynecol Obstet. 1992;251(4):181–185. doi: 10.1007/BF02718384. [DOI] [PubMed] [Google Scholar]
- Czeizel A. E., Dudás I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med. 1992 Dec 24;327(26):1832–1835. doi: 10.1056/NEJM199212243272602. [DOI] [PubMed] [Google Scholar]
- Czeizel A. E. Prevention of congenital abnormalities by periconceptional multivitamin supplementation. BMJ. 1993 Jun 19;306(6893):1645–1648. doi: 10.1136/bmj.306.6893.1645. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Holmes-Siedle M., Dennis J., Lindenbaum R. H., Galliard A. Long term effects of periconceptional multivitamin supplements for prevention of neural tube defects: a seven to 10 year follow up. Arch Dis Child. 1992 Dec;67(12):1436–1441. doi: 10.1136/adc.67.12.1436. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Laurence K. M., James N., Miller M. H., Tennant G. B., Campbell H. Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects. Br Med J (Clin Res Ed) 1981 May 9;282(6275):1509–1511. doi: 10.1136/bmj.282.6275.1509. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Smithells R. W., Sheppard S., Schorah C. J., Seller M. J., Nevin N. C., Harris R., Read A. P., Fielding D. W. Possible prevention of neural-tube defects by periconceptional vitamin supplementation. Lancet. 1980 Feb 16;1(8164):339–340. doi: 10.1016/s0140-6736(80)90886-7. [DOI] [PubMed] [Google Scholar]
- Smithells R. W., Sheppard S., Wild J., Schorah C. J. Prevention of neural tube defect recurrences in Yorkshire: final report. Lancet. 1989 Aug 26;2(8661):498–499. doi: 10.1016/s0140-6736(89)92103-x. [DOI] [PubMed] [Google Scholar]