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Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1994 Jul;71(1):3–7. doi: 10.1136/adc.71.1.3

Death in infancy from unrecognised congenital heart disease.

M Abu-Harb 1, E Hey 1, C Wren 1
PMCID: PMC1029901  PMID: 8067789

Abstract

This study was undertaken to identify all congenital heart disease in infancy, including deaths before diagnosis, to provide a truer picture of the spectrum of congenital heart disease and to assess the 'treatability' of those dying before diagnosis. All births, infant deaths, and surviving babies with congenital heart disease in one health region in 1985-90 were identified and were classified as 'complex', 'significant', or 'minor'. Of the 1074 infants diagnosed in infancy, 185 died and 56 of these (30%) died undiagnosed. Severe non-cardiac malformations were present in 29 of the 56 while 27 were otherwise normal. Cardiovascular abnormalities in the latter group were complex in 13/27 and significant in 14/27. Identification of undiagnosed cardiovascular anomalies will improve epidemiological evaluation of congenital heart disease and, more importantly, earlier recognition of treatable abnormalities may reduce mortality.

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Selected References

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  1. Allen H. D., Taubert K. A., Deckelbaum R. J., Driscoll D., Dunnigan A., Gidding S. S., Herndon P., Kavey R. E., Mullins C., Snider A. R. Poverty and cardiac disease in children. Am J Dis Child. 1991 May;145(5):550–553. doi: 10.1001/archpedi.1991.02160050076021. [DOI] [PubMed] [Google Scholar]
  2. Dickinson D. F., Arnold R., Wilkinson J. L. Congenital heart disease among 160 480 liveborn children in Liverpool 1960 to 1969. Implications for surgical treatment. Br Heart J. 1981 Jul;46(1):55–62. doi: 10.1136/hrt.46.1.55. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Ferencz C., Neill C. A., Boughman J. A., Rubin J. D., Brenner J. I., Perry L. W. Congenital cardiovascular malformations associated with chromosome abnormalities: an epidemiologic study. J Pediatr. 1989 Jan;114(1):79–86. doi: 10.1016/s0022-3476(89)80605-5. [DOI] [PubMed] [Google Scholar]
  4. Ferencz C. On the birth prevalence of congenital heart disease. J Am Coll Cardiol. 1990 Dec;16(7):1701–1702. doi: 10.1016/0735-1097(90)90322-g. [DOI] [PubMed] [Google Scholar]
  5. Ferencz C., Rubin J. D., McCarter R. J., Brenner J. I., Neill C. A., Perry L. W., Hepner S. I., Downing J. W. Congenital heart disease: prevalence at livebirth. The Baltimore-Washington Infant Study. Am J Epidemiol. 1985 Jan;121(1):31–36. doi: 10.1093/oxfordjournals.aje.a113979. [DOI] [PubMed] [Google Scholar]
  6. Fixler D. E., Pastor P., Chamberlin M., Sigman E., Eifler C. W. Trends in congenital heart disease in Dallas County births. 1971-1984. Circulation. 1990 Jan;81(1):137–142. doi: 10.1161/01.cir.81.1.137. [DOI] [PubMed] [Google Scholar]
  7. Grabitz R. G., Joffres M. R., Collins-Nakai R. L. Congenital heart disease: incidence in the first year of life. The Alberta Heritage Pediatric Cardiology Program. Am J Epidemiol. 1988 Aug;128(2):381–388. doi: 10.1093/oxfordjournals.aje.a114978. [DOI] [PubMed] [Google Scholar]
  8. Hoffman J. I., Christianson R. Congenital heart disease in a cohort of 19,502 births with long-term follow-up. Am J Cardiol. 1978 Oct;42(4):641–647. doi: 10.1016/0002-9149(78)90635-5. [DOI] [PubMed] [Google Scholar]
  9. Martin G. R., Perry L. W., Ferencz C. Increased prevalence of ventricular septal defect: epidemic or improved diagnosis. Pediatrics. 1989 Feb;83(2):200–203. [PubMed] [Google Scholar]
  10. Report of the New England Regional Infant Cardiac Program. Pediatrics. 1980 Feb;65(2 Pt 2):375–461. [PubMed] [Google Scholar]
  11. Rubin J. D., Ferencz C., Brenner J. I., Neill C. A., Perry L. W. Early detection of congenital cardiovascular malformations in infancy. Am J Dis Child. 1987 Nov;141(11):1218–1220. doi: 10.1001/archpedi.1987.04460110088031. [DOI] [PubMed] [Google Scholar]
  12. Samánek M., Goetzová J., Benesová D. Causes of death in neonates born with a heart malformation. Int J Cardiol. 1986 Apr;11(1):63–74. doi: 10.1016/0167-5273(86)90200-7. [DOI] [PubMed] [Google Scholar]
  13. Samánek M., Slavík Z., Zborilová B., Hrobonová V., Vorísková M., Skovránek J. Prevalence, treatment, and outcome of heart disease in live-born children: a prospective analysis of 91,823 live-born children. Pediatr Cardiol. 1989 Fall;10(4):205–211. doi: 10.1007/BF02083294. [DOI] [PubMed] [Google Scholar]
  14. Tubman T. R., Shields M. D., Craig B. G., Mulholland H. C., Nevin N. C. Congenital heart disease in Down's syndrome: two year prospective early screening study. BMJ. 1991 Jun 15;302(6790):1425–1427. doi: 10.1136/bmj.302.6790.1425. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Vesterby A., Nielsen K., Borg L., Paulsen S., Baandrup U. Congenital heart malformations in Jutland, Denmark: a three year necropsy study in children aged 0-14 years. Epidemiology and classification according to sequential segmental analysis. Br Heart J. 1987 Dec;58(6):653–658. doi: 10.1136/hrt.58.6.653. [DOI] [PMC free article] [PubMed] [Google Scholar]

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