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. 1994 Jul;71(1):19–23. doi: 10.1136/adc.71.1.19

Is rice based oral rehydration therapy effective in young infants?

A Islam 1, A M Molla 1, M A Ahmed 1, A Yameen 1, R Thara 1, A Molla 1, Z Issani 1, K Hendricks 1, J D Snyder 1
PMCID: PMC1029905  PMID: 8067787

Abstract

Rice based oral rehydration therapy (ORT) solutions have been shown to be superior to glucose oral rehydration salts (World Health Organisation (WHO) ORS) in reducing stool volume and duration of diarrhoea in children and adults. Rice based ORT has been used only sparingly in young infants, however, because of theoretical concerns about digestibility. A randomised controlled trial of rice based ORT (50 g rice and electrolytes identical to WHO ORS) and WHO ORS was carried out in 52 male infants less than 6 months old with moderately severe acute diarrhoea to evaluate efficacy and digestibility. Nineteen (70%) of 27 children who received rice based ORT and 18 (72%) of 25 children who received WHO ORS were treated successfully. The mean (SD) diarrhoeal stool output for the first 24 hours of treatment was significantly lower in the infants receiving the rice based ORT than in those receiving WHO ORS (101.0 (60.5) v 137.1 (74.6) g/kg). The stool output was also significantly less in the rice based ORT group in the second 24 hours. Infants in the rice based ORT group drank significantly less rehydration solution than infants in the WHO ORS group (mean (SD) 165.4 (77.4) v 217.9 (86.1) during the first 24 hours of treatment. There was no difference in the duration of diarrhoea between the groups. The volume of breast and formula feeding was similar in the two groups. No difference was seen in the frequency of finding reducing substances or acid pH in the stools of either group of children. The results suggest that rice based ORT is as effective as WHO ORS in infants with moderately severe diarrhoea and that rice based ORT is as well tolerated as WHO ORS in infants.

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Selected References

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  1. AURICCHIO S., RUBINO A., MUERSET G. INTESTINAL GLYCOSIDASE ACTIVITIES IN THE HUMAN EMBRYO, FETUS, AND NEWBORN. Pediatrics. 1965 Jun;35:944–954. [PubMed] [Google Scholar]
  2. Bhan M. K., Ghai O. P., Khoshoo V., Vasudev A. S., Bhatnagar S., Arora N. K., Rashmi, Stintzing G. Efficacy of mung bean (lentil) and pop rice based rehydration solutions in comparison with the standard glucose electrolyte solution. J Pediatr Gastroenterol Nutr. 1987 May-Jun;6(3):392–399. doi: 10.1097/00005176-198705000-00016. [DOI] [PubMed] [Google Scholar]
  3. Carpenter C. C., Greenough W. B., Pierce N. F. Oral-rehydration therapy--the role of polymeric substrates. N Engl J Med. 1988 Nov 17;319(20):1346–1348. doi: 10.1056/NEJM198811173192009. [DOI] [PubMed] [Google Scholar]
  4. Claeson M., Merson M. H. Global progress in the control of diarrheal diseases. Pediatr Infect Dis J. 1990 May;9(5):345–355. doi: 10.1097/00006454-199005000-00008. [DOI] [PubMed] [Google Scholar]
  5. De Vizia B., Ciccimarra F., De Cicco N., Auricchio S. Digestibility of starches in infants and children. J Pediatr. 1975 Jan;86(1):50–55. doi: 10.1016/s0022-3476(75)80703-7. [DOI] [PubMed] [Google Scholar]
  6. Fayad I. M., Hashem M., Duggan C., Refat M., Bakir M., Fontaine O., Santosham M. Comparative efficacy of rice-based and glucose-based oral rehydration salts plus early reintroduction of food. Lancet. 1993 Sep 25;342(8874):772–775. doi: 10.1016/0140-6736(93)91540-3. [DOI] [PubMed] [Google Scholar]
  7. Gore S. M., Fontaine O., Pierce N. F. Impact of rice based oral rehydration solution on stool output and duration of diarrhoea: meta-analysis of 13 clinical trials. BMJ. 1992 Feb 1;304(6822):287–291. doi: 10.1136/bmj.304.6822.287. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Heitlinger L. A., Lee P. C., Dillon W. P., Lebenthal E. Mammary amylase: a possible alternate pathway of carbohydrate digestion in infancy. Pediatr Res. 1983 Jan;17(1):15–18. doi: 10.1203/00006450-198301000-00003. [DOI] [PubMed] [Google Scholar]
  9. Hirschhorn N., Greenough W. B., 3rd Progress in oral rehydration therapy. Sci Am. 1991 May;264(5):50–56. doi: 10.1038/scientificamerican0591-50. [DOI] [PubMed] [Google Scholar]
  10. Kien C. L., Liechty E. A., Myerberg D. Z., Mullett M. D. Dietary carbohydrate assimilation in the premature infant: evidence for a nutritionally significant bacterial ecosystem in the colon. Am J Clin Nutr. 1987 Sep;46(3):456–460. doi: 10.1093/ajcn/46.3.456. [DOI] [PubMed] [Google Scholar]
  11. Lebenthal E., Lee P. C. Glucoamylase and disaccharidase activities in normal subjects and in patients with mucosal injury of the small intestine. J Pediatr. 1980 Sep;97(3):389–393. doi: 10.1016/s0022-3476(80)80187-9. [DOI] [PubMed] [Google Scholar]
  12. Lifschitz C. H., Irving C. S., Gopalakrishna G. S., Evans K., Nichols B. L. Carbohydrate malabsorption in infants with diarrhea studied with the breath hydrogen test. J Pediatr. 1983 Mar;102(3):371–375. doi: 10.1016/s0022-3476(83)80651-9. [DOI] [PubMed] [Google Scholar]
  13. Mehta M. N., Subramaniam S. Comparison of rice water, rice electrolyte solution, and glucose electrolyte solution in the management of infantile diarrhoea. Lancet. 1986 Apr 12;1(8485):843–845. doi: 10.1016/s0140-6736(86)90948-7. [DOI] [PubMed] [Google Scholar]
  14. Mobassaleh M., Montgomery R. K., Biller J. A., Grand R. J. Development of carbohydrate absorption in the fetus and neonate. Pediatrics. 1985 Jan;75(1 Pt 2):160–166. [PubMed] [Google Scholar]
  15. Mohan M., Sethi J. S., Daral T. S., Sharma M., Bhargava S. K., Sachdev H. P. Controlled trial of rice powder and glucose rehydration solutions as oral therapy for acute dehydrating diarrhea in infants. J Pediatr Gastroenterol Nutr. 1986 May-Jun;5(3):423–427. doi: 10.1097/00005176-198605000-00015. [DOI] [PubMed] [Google Scholar]
  16. Molla A. M., Molla A., Nath S. K., Khatun M. Food-based oral rehydration salt solution for acute childhood diarrhoea. Lancet. 1989 Aug 19;2(8660):429–431. doi: 10.1016/s0140-6736(89)90601-6. [DOI] [PubMed] [Google Scholar]
  17. Molla A. M., Sarker S. A., Hossain M., Molla A., Greenough W. B., 3rd Rice-powder electrolyte solution as oral-therapy in diarrhoea due to Vibrio cholerae and Escherichia coli. Lancet. 1982 Jun 12;1(8285):1317–1319. doi: 10.1016/s0140-6736(82)92396-0. [DOI] [PubMed] [Google Scholar]
  18. Patra F. C., Mahalanabis D., Jalan K. N., Sen A., Banerjee P. Is oral rice electrolyte solution superior to glucose electrolyte solution in infantile diarrhoea? Arch Dis Child. 1982 Dec;57(12):910–912. doi: 10.1136/adc.57.12.910. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Pizarro D., Posada G., Sandi L., Moran J. R. Rice-based oral electrolyte solutions for the management of infantile diarrhea. N Engl J Med. 1991 Feb 21;324(8):517–521. doi: 10.1056/NEJM199102213240802. [DOI] [PubMed] [Google Scholar]
  20. Rabbani G. H., Lu R. B., Horvath K., Lebenthal E. Short-chain glucose polymer and anthracene-9-carboxylic acid inhibit water and electrolyte secretion induced by dibutyryl cyclic AMP in the small intestine. Gastroenterology. 1991 Oct;101(4):1046–1053. doi: 10.1016/0016-5085(91)90732-z. [DOI] [PubMed] [Google Scholar]
  21. el-Mougi M., Hegazi E., Galal O., el Akkad N., el-Abhar A., Nour N., el-Hadi Emam M., Ahmadi A. R. Controlled clinical trial on the efficacy of rice powder-based oral rehydration solution on the outcome of acute diarrhea in infants. J Pediatr Gastroenterol Nutr. 1988 Jul-Aug;7(4):572–576. doi: 10.1097/00005176-198807000-00016. [DOI] [PubMed] [Google Scholar]

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