Abstract
Glucocorticoid suppressible hyperaldosteronism (GSH) is an uncommon form of dominantly inherited hypertension. Presentation with hypertension and complications such as stroke in early life are well recognised. The use of a simple genetic test carried out on blood or placenta facilitates the detection of infants and children with GSH before the development of hypertension, allowing prompt treatment of hypertension if it occurs, and an opportunity to study the effects of growth and environmental influences on the progression of the condition.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Connell J. M., Kenyon C. J., Corrie J. E., Fraser R., Watt R., Lever A. F. Dexamethasone-suppressible hyperaldosteronism. Adrenal transition cell hyperplasia? Hypertension. 1986 Aug;8(8):669–676. doi: 10.1161/01.hyp.8.8.669. [DOI] [PubMed] [Google Scholar]
- Jamieson A., Connell J. M., Fraser R. Glucocorticoid-suppressible hyperaldosteronism: from confusion to conclusion? J Mol Endocrinol. 1993 Feb;10(1):3–5. doi: 10.1677/jme.0.0100003. [DOI] [PubMed] [Google Scholar]
- Lee S. M., Lightner E., Witte M., Oberfield S., Levine L., New M. I. Dexamethasone suppressible hyperaldosteronism in a child with nephrosclerosis. Acta Endocrinol (Copenh) 1982 Feb;99(2):251–255. doi: 10.1530/acta.0.0990251. [DOI] [PubMed] [Google Scholar]
- Lifton R. P., Dluhy R. G., Powers M., Rich G. M., Cook S., Ulick S., Lalouel J. M. A chimaeric 11 beta-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension. Nature. 1992 Jan 16;355(6357):262–265. doi: 10.1038/355262a0. [DOI] [PubMed] [Google Scholar]
- Lifton R. P., Dluhy R. G., Powers M., Rich G. M., Gutkin M., Fallo F., Gill J. R., Jr, Feld L., Ganguly A., Laidlaw J. C. Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase. Nat Genet. 1992 Sep;2(1):66–74. doi: 10.1038/ng0992-66. [DOI] [PubMed] [Google Scholar]
- Pascoe L., Curnow K. M., Slutsker L., Connell J. M., Speiser P. W., New M. I., White P. C. Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):8327–8331. doi: 10.1073/pnas.89.17.8327. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rich G. M., Ulick S., Cook S., Wang J. Z., Lifton R. P., Dluhy R. G. Glucocorticoid-remediable aldosteronism in a large kindred: clinical spectrum and diagnosis using a characteristic biochemical phenotype. Ann Intern Med. 1992 May 15;116(10):813–820. doi: 10.7326/0003-4819-116-10-813. [DOI] [PubMed] [Google Scholar]