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. 1994 Aug;71(2):133–137. doi: 10.1136/adc.71.2.133

Pulmonary function in infants with cystic fibrosis: the effect of antibiotic treatment.

C S Beardsmore 1, J R Thompson 1, A Williams 1, E K McArdle 1, G A Gregory 1, L T Weaver 1, H Simpson 1
PMCID: PMC1029944  PMID: 7944533

Abstract

Since 1982 all infants born within the East Anglian Regional Health Authority have been screened for cystic fibrosis. Between April 1985 and April 1992 infants identified in this way have been entered into a randomised prospective controlled trial of antibiotic prophylaxis. Approximately half the infants received continuous oral flucloxacillin and the remainder received antibiotics when clinically indicated. Infants underwent tests of respiratory function at 3-4 months and at 1 year of age. Measurements of thoracic gas volume and airway conductance were made with an infant whole body plethysmograph, and maximum expiratory flow by the 'squeeze' technique. A total of 73 tests was performed of 42 infants. To facilitate comparisons, measurements were expressed as scores. The mean values of the scores for the two groups of infants fell within normal limits. There was no difference between the treatment groups at either age. A reduction in airways conductance was observed between the two tests.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Accurso F. J., Sokol R. J., Hammond K. B., Abman S. H. Early respiratory course in infants with cystic fibrosis: relevance to newborn screening. Pediatr Pulmonol Suppl. 1991;7:42–45. doi: 10.1002/ppul.1950110709. [DOI] [PubMed] [Google Scholar]
  2. Beardsmore C. S., Bar-Yishay E., Maayan C., Yahav Y., Katznelson D., Godfrey S. Lung function in infants with cystic fibrosis. Thorax. 1988 Jul;43(7):545–551. doi: 10.1136/thx.43.7.545. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Chatfield S., Owen G., Ryley H. C., Williams J., Alfaham M., Goodchild M. C., Weller P. Neonatal screening for cystic fibrosis in Wales and the West Midlands: clinical assessment after five years of screening. Arch Dis Child. 1991 Jan;66(1 Spec No):29–33. doi: 10.1136/adc.66.1_spec_no.29. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dankert-Roelse J. E., te Meerman G. J., Martijn A., ten Kate L. P., Knol K. Survival and clinical outcome in patients with cystic fibrosis, with or without neonatal screening. J Pediatr. 1989 Mar;114(3):362–367. doi: 10.1016/s0022-3476(89)80552-9. [DOI] [PubMed] [Google Scholar]
  5. Fergusson D. M., Horwood L. J., Shannon F. T. Parental smoking and respiratory illness in infancy. Arch Dis Child. 1980 May;55(5):358–361. doi: 10.1136/adc.55.5.358. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Godfrey S., Mearns M., Howlett G. Serial lung function studies in cystic fibrosis in the first 5 years of life. Arch Dis Child. 1978 Jan;53(1):83–85. doi: 10.1136/adc.53.1.83. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Green M. R., Weaver L. T., Heeley A. F., Nicholson K., Kuzemko J. A., Barton D. E., McMahon R., Payne S. J., Austin S., Yates J. R. Cystic fibrosis identified by neonatal screening: incidence, genotype, and early natural history. Arch Dis Child. 1993 Apr;68(4):464–467. doi: 10.1136/adc.68.4.464. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hampton F., Beardsmore C. S., Morgan W., Williams A., Taussig L., Thompson J. R. A scoring system for lung function tests in infants. Pediatr Pulmonol. 1992 Nov;14(3):149–155. doi: 10.1002/ppul.1950140303. [DOI] [PubMed] [Google Scholar]
  9. Heeley A. F., Heeley M. E., King D. N., Kuzemko J. A., Walsh M. P. Screening for cystic fibrosis by died blood spot trypsin assay. Arch Dis Child. 1982 Jan;57(1):18–21. [PMC free article] [PubMed] [Google Scholar]
  10. Johansen H. K., Nir M., Høiby N., Koch C., Schwartz M. Severity of cystic fibrosis in patients homozygous and heterozygous for delta F508 mutation. Lancet. 1991 Mar 16;337(8742):631–634. doi: 10.1016/0140-6736(91)92449-c. [DOI] [PubMed] [Google Scholar]
  11. Kerem E., Corey M., Kerem B., Durie P., Tsui L. C., Levison H. Clinical and genetic comparisons of patients with cystic fibrosis, with or without meconium ileus. J Pediatr. 1989 May;114(5):767–773. doi: 10.1016/s0022-3476(89)80134-9. [DOI] [PubMed] [Google Scholar]
  12. Loening-Baucke V. A., Mischler E., Myers M. G. A placebo-controlled trial of cephalexin therapy in the ambulatory management of patients with cystic fibrosis. J Pediatr. 1979 Oct;95(4):630–637. doi: 10.1016/s0022-3476(79)80785-4. [DOI] [PubMed] [Google Scholar]
  13. Pedreira F. A., Guandolo V. L., Feroli E. J., Mella G. W., Weiss I. P. Involuntary smoking and incidence of respiratory illness during the first year of life. Pediatrics. 1985 Mar;75(3):594–597. [PubMed] [Google Scholar]
  14. Phelan P. D., Gracey M., Williams H. E., Anderson C. M. Ventilatory function in infants with cystic fibrosis. Physiological assessment of halation therapy. Arch Dis Child. 1969 Jun;44(235):393–400. doi: 10.1136/adc.44.235.393. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Silverman M., Prendiville A., Green S. Partial expiratory flow-volume curves in infancy: technical aspects. Bull Eur Physiopathol Respir. 1986 May-Jun;22(3):257–262. [PubMed] [Google Scholar]
  16. Stocks J., Levy N. M., Godfrey S. A new apparatus for the accurate measurement of airway resistance in infancy. J Appl Physiol Respir Environ Exerc Physiol. 1977 Jul;43(1):155–159. doi: 10.1152/jappl.1977.43.1.155. [DOI] [PubMed] [Google Scholar]
  17. Taussig L. M., Landau L. I., Godfrey S., Arad I. Determinants of forced expiratory flows in newborn infants. J Appl Physiol Respir Environ Exerc Physiol. 1982 Nov;53(5):1220–1227. doi: 10.1152/jappl.1982.53.5.1220. [DOI] [PubMed] [Google Scholar]
  18. Tepper R. S., Hiatt P., Eigen H., Scott P., Grosfeld J., Cohen M. Infants with cystic fibrosis: pulmonary function at diagnosis. Pediatr Pulmonol. 1988;5(1):15–18. doi: 10.1002/ppul.1950050105. [DOI] [PubMed] [Google Scholar]
  19. Weaver L. T., Green M. R., Nicholson K., Mills J., Heeley M. E., Kuzemko J. A., Austin S., Gregory G. A., Dux A. E., Davis J. A. Prognosis in cystic fibrosis treated with continuous flucloxacillin from the neonatal period. Arch Dis Child. 1994 Feb;70(2):84–89. doi: 10.1136/adc.70.2.84. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Wesley A. W., Smith P. A., Elliott R. B. Experience with neonatal screening for cystic fibrosis in New Zealand using measurement of immunoreactive trypsinogen. Aust Paediatr J. 1989 Jun;25(3):151–155. doi: 10.1111/j.1440-1754.1989.tb01440.x. [DOI] [PubMed] [Google Scholar]
  21. Zach M. S. Lung disease in cystic fibrosis--an updated concept. Pediatr Pulmonol. 1990;8(3):188–202. doi: 10.1002/ppul.1950080311. [DOI] [PubMed] [Google Scholar]
  22. al-Jader L. N., Meredith A. L., Ryley H. C., Cheadle J. P., Maguire S., Owen G., Goodchild M. C., Harper P. S. Severity of chest disease in cystic fibrosis patients in relation to their genotypes. J Med Genet. 1992 Dec;29(12):883–887. doi: 10.1136/jmg.29.12.883. [DOI] [PMC free article] [PubMed] [Google Scholar]

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