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. 1994 Aug;71(2):144–146. doi: 10.1136/adc.71.2.144

Long-term follow up in type A insulin resistant syndrome treated by insulin-like growth factor I.

H Ishihama 1, Y Suzuki 1, K Muramatsu 1, M Nagai 1, M Kokubo 1, H Shiraya 1, A Kawakita 1, Y Nishimura 1, T Imamura 1, M Kobayashi 1
PMCID: PMC1029947  PMID: 7944536

Abstract

Insulin-like growth factor I (IGF-I) is a useful therapeutic agent in insulin resistant diabetes mellitus due to insulin receptor disease because of its hypoglycaemic effects through the IGF-I receptor. A girl with typical type A insulin resistant syndrome was treated with IGF-I for two years and the treatment was effective in ameliorating hyperglycaemia. Overproduction of testosterone in polycystic ovaries was aggravated with this treatment, however. Therefore, IGF-I treatment may be used for glycaemic control but with caution because of its possible side effect of aggravating hyperandrogenism in these patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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