Table 3.
Mediating role of α-klotho in the association between standardized HEI 2015 scores and eGFR among 12,817 participants aged 40–79 years in the NHANES.
| Weighted β Coefficient (95% CI) for eGFR | ||||
|---|---|---|---|---|
| Mediator: α-Klotho |
Total Effect | Direct Effect | Indirect Effect | Proportion Mediated, % (95%CI) |
| Overall HEI-2015 | 0.94 (0.64, 1.23) * | 0.88 (0.59, 1.19) * | 0.05 (0.02, 0.08) * | 5.8 (2.6, 10.0) * |
| Total fruits | 0.55 (0.26, 0.85) * | 0.49 (0.20, 0.82) * | 0.06 (0.03, 0.09) * | 10.5 (4.3, 23.0) * |
| Whole fruits | 0.69 (0.40, 0.99) * | 0.62 (0.31, 0.90) * | 0.07 (0.04, 0.10) * | 9.6 (5.1, 19.0) * |
| Total vegetables | 0.59 (0.30, 0.88) * | 0.57 (0.27, 0.87) * | 0.02 (−0.01, 0.06) | - |
| Greens and beans | 0.63 (0.34, 0.92) * | 0.60 (0.33, 0.88) * | 0.04 (0.01, 0.07) * | 5.6 (1.2, 13.0) * |
| Whole grain | 0.56 (0.27, 0.85) * | 0.51 (0.21, 0.82) * | 0.05 (0.02, 0.08) * | 8.4 (3.3, 20.0) * |
| Refined grain | −0.14 (−0.43, 0.16) | −0.16 (−0.45, 0.12) | 0.02 (−0.01, 0.05) | - |
| Total dairy | 0.17 (−0.12, 0.46) | 0.13 (−0.15, 0.41) | 0.04 (−0.01, 0.07) | - |
| Total protein | −0.02 (−0.30, 0.27) | −0.04 (−0.34, 0.23) | 0.03 (−0.01, 0.06) | - |
| Seafood and plant protein | 0.63 (0.34, 0.92) * | 0.60 (0.31, 0.91) * | 0.03 (−0.01, 0.05) | - |
| Fatty acid | 0.31 (0.02, 0.59) * | 0.29 (−0.01, 0.60) | 0.02 (−0.01, 0.05) | - |
| Saturated fat | 0.31 (0.02, 0.60) * | 0.32 (0.02, 0.61) * | −0.01 (−0.04, 0.02) | - |
| Sodium | −0.17 (−0.46, 0.12) | −0.15 (−0.45, 0.12) | −0.02 (−0.05, 0.01) | - |
| Added sugar | 0.76 (0.47, 1.06) * | 0.79 (0.50, 1.08) * | −0.02 (−0.06, 0.01) | - |
Model adjusted for age, sex, race, education, income, total energy intake, alcohol intake, smoking, physical activity, BMI, self-reported hypertension, self-reported diabetes, and self-reported cardiovascular disease; * p < 0.05.