Table 2.
The functional consequences of high-risk missense SNPs in ANGPTL proteins, perturbing PTM sites, ligand-binding sites, and associated cancer types.
| Protein | High-Risk SNPs | Conserved (100%) | I-Mutant Analysis | PTM Site | Ligand-Binding Site | Associated Cancer Type | ||
|---|---|---|---|---|---|---|---|---|
| DDG | Stability | Reliability Index | ||||||
| ANGPTL3 | L57H | Yes | −0.44 | Decrease | 5 | - | - | Kidney |
| T64K | Yes | −2.41 | Decrease | 8 | Yes | Yes | - | |
| T64R | Yes | −1.33 | Decrease | 3 | - | Yes | - | |
| S292P | Yes | −1.41 | Increase | 2 | Yes | - | - | |
| F295L | Yes | −2.25 | Decrease | 6 | - | - | Lung | |
| L309F | Yes | −0.18 | Decrease | 6 | - | - | Endometrium | |
| K319M | Yes | −0.15 | Increase | 3 | - | - | Skin | |
| Y321D | Yes | −0.32 | Decrease | 4 | Yes | - | - | |
| R332L | Yes | −1.64 | Decrease | 9 | - | - | Large intestine | |
| R332Q | Yes | −1.59 | Decrease | 9 | - | - | Large intestine | |
| S348C | Yes | −1.27 | Decrease | 2 | Yes | - | Esophagus | |
| Y358H | Yes | −0.35 | Decrease | 6 | Yes | - | - | |
| G409R | Yes | 0.14 | Decrease | 5 | CNS | |||
| S446P | No | −1.63 | Increase | 3 | Yes | - | - | |
| S447I | No | −1.69 | Decrease | 6 | Yes | - | - | |
| ANGPTL8 | P23L | No | 0.06 | Increase | 3 | - | - | Large intestine |
| R85W | No | −0.17 | Decrease | 7 | - | - | Large intestine | |
| R138S | No | −1.18 | Decrease | 9 | - | - | Breast | |
| E148D | Yes | −0.65 | Decrease | 7 | - | - | Liver | |