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. Author manuscript; available in PMC: 2024 May 11.
Published in final edited form as: Cell. 2023 May 2;186(10):2160–2175.e17. doi: 10.1016/j.cell.2023.04.010

Figure 5. Anti-depressive-like effects of compounds 8090 and 8219 in the tail suspension test with Vmat2 mice.

Figure 5.

(A-B) Acute effects of ‘8090 (0.5, 1, and 2 mg/kg) and ‘8219 (0.1, 0.5, and 1 mg/kg) 30 min after injection in wild-type (WT) and VMAT2 heterozygous (HET) mice. Controls were given the vehicle (Veh), 20 mg/kg fluoxetine (Flx), or 30 mg/kg ibogaine (Ibo). (C-D) Persistent effects of ‘8090 and ‘8219 1 day post-injection in WT and VMAT2 HET mice. N=8–10 mice/genotype/treatment. All primary statistics are found in Table S9.