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. 1988 Feb;51(2):260–265. doi: 10.1136/jnnp.51.2.260

Perivascular iron deposition and other vascular damage in multiple sclerosis.

C W Adams 1
PMCID: PMC1031540  PMID: 3346691

Abstract

Evidence of damage to cerebral vein walls was sought in 70 cases of multiple sclerosis. Seventy control cases were also examined. The multiple sclerosis cases showed venous intramural fibrinoid deposition (7%), recent haemorrhages (17%), old haemorrhages revealed by haemosiderin deposition (30%), thrombosis (6%) and thickened veins (19%). In all, 41% of all multiple sclerosis cases showed some evidence of vein damage. Occasional control cases showed haemosiderin deposition in the brain but, unlike the multiple sclerosis cases, these were diffuse and almost entirely related to coexistent cardiovascular or cerebrovascular disease. Haemosiderin deposition was common in the substantia nigra and other pigmented nuclei in all cases. It is concluded that the cerebral vein wall in multiple sclerosis is subject to chronic inflammatory damage, which promotes haemorrhage and increased permeability, and constitutes a form of vasculitis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adams C. W. Pathology of multiple sclerosis: progression of the lesion. Br Med Bull. 1977 Jan;33(1):15–20. doi: 10.1093/oxfordjournals.bmb.a071388. [DOI] [PubMed] [Google Scholar]
  2. Adams C. W., Poston R. N., Buk S. J., Sidhu Y. S., Vipond H. Inflammatory vasculitis in multiple sclerosis. J Neurol Sci. 1985 Jul;69(3):269–283. doi: 10.1016/0022-510x(85)90139-x. [DOI] [PubMed] [Google Scholar]
  3. Adams C. W. The onset and progression of the lesion in multiple sclerosis. J Neurol Sci. 1975 Jun;25(2):165–182. doi: 10.1016/0022-510x(75)90138-0. [DOI] [PubMed] [Google Scholar]
  4. Allen I. V., Millar J. H., Hutchinson M. J. General disease in 120 necropsy-proven cases of multiple sclerosis. Neuropathol Appl Neurobiol. 1978 Jul-Aug;4(4):279–284. doi: 10.1111/j.1365-2990.1978.tb00546.x. [DOI] [PubMed] [Google Scholar]
  5. Brown W. J. The capillaries in acute and subacute multiple sclerosis plaques: a morphometric analysis. Neurology. 1978 Sep;28(9 Pt 2):84–92. doi: 10.1212/wnl.28.9_part_2.84. [DOI] [PubMed] [Google Scholar]
  6. Craelius W., Migdal M. W., Luessenhop C. P., Sugar A., Mihalakis I. Iron deposits surrounding multiple sclerosis plaques. Arch Pathol Lab Med. 1982 Aug;106(8):397–399. [PubMed] [Google Scholar]
  7. Engell T., Hvidberg A., Uhrenholdt A. Multiple sclerosis: periphlebitis retinalis et cerebro-spinalis. A correlation between periphlebitis retinalis and abnormal technetium brain scintigraphy. Acta Neurol Scand. 1984 May;69(5):293–297. doi: 10.1111/j.1600-0404.1984.tb07815.x. [DOI] [PubMed] [Google Scholar]
  8. Esiri M. M. Multiple sclerosis: a quantitative and qualitative study of immunoglobulin-containing cells in the central nervous system. Neuropathol Appl Neurobiol. 1980 Jan-Feb;6(1):9–21. doi: 10.1111/j.1365-2990.1980.tb00199.x. [DOI] [PubMed] [Google Scholar]
  9. Guseo A., Jellinger K. The significance of perivascular infiltrations in multiple sclerosis. J Neurol. 1975 Dec 2;211(1):51–60. doi: 10.1007/BF00312463. [DOI] [PubMed] [Google Scholar]
  10. Jankovic J., Derman H., Armstrong D. Haemorrhagic complications of multiple sclerosis. J Neurol Neurosurg Psychiatry. 1980 Jan;43(1):76–81. doi: 10.1136/jnnp.43.1.76. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. LENDRUM A. C. The hypertensive diabetic kidney as a model of the so-called collagen diseases. Can Med Assoc J. 1963 Mar 2;88:442–452. [PMC free article] [PubMed] [Google Scholar]
  12. Schelling F. Damaging venous reflux into the skull or spine: relevance to multiple sclerosis. Med Hypotheses. 1986 Oct;21(2):141–148. doi: 10.1016/0306-9877(86)90003-4. [DOI] [PubMed] [Google Scholar]
  13. Tanaka R., Iwasaki Y., Koprowski H. Ultrastructural studies of perivascular cuffing cells in multiple sclerosis brain. Am J Pathol. 1975 Dec;81(3):467–478. [PMC free article] [PubMed] [Google Scholar]
  14. Walton J. C., Kaufmann J. C. Iron deposits and multiple sclerosis. Arch Pathol Lab Med. 1984 Sep;108(9):755–756. [PubMed] [Google Scholar]
  15. ZIMMERMAN H. M., NETSKY M. G. The pathology of multiple sclerosis. Res Publ Assoc Res Nerv Ment Dis. 1950;28:271–312. [PubMed] [Google Scholar]

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