Abstract
A retrospective analysis of 350 treatment courses using high dose pulsed intravenous methylprednisolone for relapses of multiple sclerosis revealed a low number of adverse effects. This study confirms that high dose methylprednisolone is a safe therapeutic option in multiple sclerosis.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Barnes M. P., Bateman D. E., Cleland P. G., Dick D. J., Walls T. J., Newman P. K., Saunders M., Tilley P. J. Intravenous methylprednisolone for multiple sclerosis in relapse. J Neurol Neurosurg Psychiatry. 1985 Feb;48(2):157–159. doi: 10.1136/jnnp.48.2.157. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Buckley C., Kennard C., Swash M. Treatment of acute exacerbations of multiple sclerosis with intravenous methyl-prednisolone. J Neurol Neurosurg Psychiatry. 1982 Feb;45(2):179–180. doi: 10.1136/jnnp.45.2.179-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cathcart E. S., Idelson B. A., Scheinberg M. A., Couser W. G. Beneficial effects of methylprednisolone "pulse" therapy in diffuse proliferative lupus nephritis. Lancet. 1976 Jan 24;1(7952):163–166. doi: 10.1016/s0140-6736(76)91272-1. [DOI] [PubMed] [Google Scholar]
- Cerilli J., Miller J. A. The effect of massive pulse steroid therapy on the water content of the rat brain. Transplantation. 1972 Sep;14(3):403–405. [PubMed] [Google Scholar]
- Dowling P. C., Bosch V. V., Cook S. D. Possible beneficial effect of high-dose intravenous steroid therapy in acute demyelinating disease and transverse myelitis. Neurology. 1980 Jul;30(7 Pt 2):33–36. doi: 10.1212/wnl.30.7_part_2.33. [DOI] [PubMed] [Google Scholar]
- Durrant S., Chipping P. M., Palmer S., Gordon-Smith E. C. Cyclosporin A, methylprednisolone, and convulsions. Lancet. 1982 Oct 9;2(8302):829–830. doi: 10.1016/s0140-6736(82)92727-1. [DOI] [PubMed] [Google Scholar]
- FUNKHOUSER J. B., NAGLER B. The electroencephalogram of multiple sclerosis; a preliminary report. Dis Nerv Syst. 1959 Jan;20(1):41–44. [PubMed] [Google Scholar]
- MATTHEWS W. B. Epilepsy and disseminated sclerosis. Q J Med. 1962 Apr;31:141–155. [PubMed] [Google Scholar]
- Milligan N. M., Newcombe R., Compston D. A. A double-blind controlled trial of high dose methylprednisolone in patients with multiple sclerosis: 1. Clinical effects. J Neurol Neurosurg Psychiatry. 1987 May;50(5):511–516. doi: 10.1136/jnnp.50.5.511. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Moses R. E., McCormick A., Nickey W. Fatal arrhythmia after pulse methylprednisolone therapy. Ann Intern Med. 1981 Dec;95(6):781–782. doi: 10.7326/0003-4819-95-6-781_3. [DOI] [PubMed] [Google Scholar]
- Neild G. H., Lee H. A. Methylprednisolone pulse therapy in the treatment of polyarteritis nodosa. Postgrad Med J. 1977 Jul;53(621):382–387. doi: 10.1136/pgmj.53.621.382. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Newman P. K., Saunders M., Tilley P. J. Methylprednisolone therapy in multiple sclerosis. J Neurol Neurosurg Psychiatry. 1982 Oct;45(10):941–942. doi: 10.1136/jnnp.45.10.941. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stubbs S. S., Morrell R. M. Intravenous methylprednisolone sodium succinate: adverse reactions reported in association with immunosuppresive therapy. Transplant Proc. 1973 Jun;5(2):1145–1146. [PubMed] [Google Scholar]
- Williams I. A., Baylis E. M., Shipley M. E. A double-blind placebo-controlled trial of methylprednisolone pulse therapy in active rheumatoid disease. Lancet. 1982 Jul 31;2(8292):237–240. doi: 10.1016/s0140-6736(82)90323-3. [DOI] [PubMed] [Google Scholar]