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. 1988 Feb;51(2):301–304. doi: 10.1136/jnnp.51.2.301

Race-gender differences in serum creatine kinase activity: a study among South Africans.

R F Gledhill 1, C A Van der Merwe 1, M Greyling 1, M M Van Niekerk 1
PMCID: PMC1031551  PMID: 3346700

Abstract

Higher levels of total serum creatine kinase activity have been reported in black compared with white North Americans of the same sex. In a study among South Africans, we found such an interracial difference was notable only for males. The difference was heightened by physical activity. This study affirms the importance of sampling the indigenous population when developing a reference range for total creatine kinase activity.

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Selected References

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  1. Altman D. G., Gore S. M., Gardner M. J., Pocock S. J. Statistical guidelines for contributors to medical journals. Br Med J (Clin Res Ed) 1983 May 7;286(6376):1489–1493. doi: 10.1136/bmj.286.6376.1489. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Berg A., Haralambie G. Changes in serum creatine kinase and hexose phosphate isomerase activity with exercise duration. Eur J Appl Physiol Occup Physiol. 1978 Sep 15;39(3):191–201. doi: 10.1007/BF00421346. [DOI] [PubMed] [Google Scholar]
  3. Black H. R., Quallich H., Gareleck C. B. Racial differences in serum creatine kinase levels. Am J Med. 1986 Sep;81(3):479–487. doi: 10.1016/0002-9343(86)90303-7. [DOI] [PubMed] [Google Scholar]
  4. Bulpitt C. J. Confidence intervals. Lancet. 1987 Feb 28;1(8531):494–497. doi: 10.1016/s0140-6736(87)92100-3. [DOI] [PubMed] [Google Scholar]
  5. Bundey S., Crawley J. M., Edwards J. H., Westhead R. A. Serum creatine kinase levels in pubertal, mature, pregnant, and postmenopausal women. J Med Genet. 1979 Apr;16(2):117–121. doi: 10.1136/jmg.16.2.117. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cohen L., Morgan J. Diethylstilbestrol effects on serum enzymes and isozymes in muscular dystrophy. Arch Neurol. 1976 Jul;33(7):480–484. doi: 10.1001/archneur.1976.00500070022004. [DOI] [PubMed] [Google Scholar]
  7. Gledhill R. F., van Niekerk M. M., van der Merwe C. A. Racial differences in serum creatine kinase levels. Am J Med. 1987 Aug;83(2):365–366. doi: 10.1016/0002-9343(87)90715-7. [DOI] [PubMed] [Google Scholar]
  8. Goode D. J., Meltzer H. Y. Effects of isometric exercise on serum creatine phosphokinase activity. Arch Gen Psychiatry. 1976 Oct;33(10):1207–1211. doi: 10.1001/archpsyc.1976.01770100069007. [DOI] [PubMed] [Google Scholar]
  9. Griffiths P. D. Serum levels of ATP: creatine phosphotransferase (creatine kinase). The normal range and effect of muscular activity. Clin Chim Acta. 1966 Apr;13(4):413–420. doi: 10.1016/0009-8981(66)90230-0. [DOI] [PubMed] [Google Scholar]
  10. Hudgson P., Gardner-Medwin D., Pennington R. J., Walton J. N. Studies of the carrier state in the Duchenne type of muscular dystrophy. I. Effect of exercise on serum creatine kinase activity. J Neurol Neurosurg Psychiatry. 1967 Oct;30(5):416–419. doi: 10.1136/jnnp.30.5.416. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hunter J. B., Critz J. B. Effect of training on plasma enzyme levels in man. J Appl Physiol. 1971 Jul;31(1):20–23. doi: 10.1152/jappl.1971.31.1.20. [DOI] [PubMed] [Google Scholar]
  12. King S. W., Statland B. E., Savory J. The effect of a short burst of exercise on activity values of enzymes in sera of healthy young men. Clin Chim Acta. 1976 Oct 15;72(2):211–218. doi: 10.1016/0009-8981(76)90075-9. [DOI] [PubMed] [Google Scholar]
  13. Lane R. J., Roses A. D. Variation of serum creatine kinase levels with age in normal females: implications for genetic counselling in Duchenne muscular dystrophy. Clin Chim Acta. 1981 Jun 2;113(1):75–86. doi: 10.1016/0009-8981(81)90442-3. [DOI] [PubMed] [Google Scholar]
  14. Lott J. A., Landesman P. W. The enzymology of skeletal muscle disorders. Crit Rev Clin Lab Sci. 1984;20(2):153–190. doi: 10.3109/10408368409165773. [DOI] [PubMed] [Google Scholar]
  15. Meltzer H. Y., Dorus E., Grunhaus L., Davis J. M., Belmaker R. Genetic control of human plasma creatine phosphokinase activity. Clin Genet. 1978 Apr;13(4):321–326. doi: 10.1111/j.1399-0004.1978.tb01187.x. [DOI] [PubMed] [Google Scholar]
  16. Meltzer H. Y. Factors affecting serum creatine phosphokinase levels in the general population: the role of race, activity and age. Clin Chim Acta. 1971 Jun;33(1):165–172. doi: 10.1016/0009-8981(71)90264-6. [DOI] [PubMed] [Google Scholar]
  17. Meltzer H. Y., Holy P. A. Black-white differences in serum creatine phosphokinase (CPK) activity. Clin Chim Acta. 1974 Jul 31;54(2):215–224. doi: 10.1016/0009-8981(74)90239-3. [DOI] [PubMed] [Google Scholar]
  18. Meltzer H. Y. Letter: Interpretation of CPK activity. JAMA. 1974 Aug 26;229(9):1169–1169. [PubMed] [Google Scholar]
  19. Misner J. E., Massey B. H., Williams B. T. The effect of physical training on the response of serum enzymes to exercise stress. Med Sci Sports. 1973 Summer;5(2):86–88. [PubMed] [Google Scholar]
  20. Newham D. J., Jones D. A., Edwards R. H. Large delayed plasma creatine kinase changes after stepping exercise. Muscle Nerve. 1983 Jun;6(5):380–385. doi: 10.1002/mus.880060507. [DOI] [PubMed] [Google Scholar]
  21. Nicholson G. A., Morgan G., Meerkin M., Strauss E., McLeod J. G. The creatine kinase reference interval. An assessment of intra- and inter-individual variation. J Neurol Sci. 1985 Dec;71(2-3):225–231. doi: 10.1016/0022-510x(85)90061-9. [DOI] [PubMed] [Google Scholar]
  22. Norton J. P., Clarkson P. M., Graves J. E., Litchfield P., Kirwan J. Serum creatine kinase activity and body composition in males and females. Hum Biol. 1985 Dec;57(4):591–598. [PubMed] [Google Scholar]
  23. Paterson Y., Lawrence E. F. Factors affecting serum creatine phosphokinase levels in normal adult females. Clin Chim Acta. 1972 Nov;42(1):131–139. doi: 10.1016/0009-8981(72)90386-5. [DOI] [PubMed] [Google Scholar]
  24. Perry T. B., Fraser F. C. Variability of serum creatine phosphokinase activity in normal women and carriers of the gene for Duchenne muscular dystrophy. Neurology. 1973 Dec;23(12):1316–1323. doi: 10.1212/wnl.23.12.1316. [DOI] [PubMed] [Google Scholar]
  25. Rawle J., Knight J. A. Elevated creatine phosphokinase in blood donors. Am J Clin Pathol. 1971 Aug;56(2):253–254. doi: 10.1093/ajcp/56.2.253. [DOI] [PubMed] [Google Scholar]
  26. Satapathy R. K., Skinner R. Serum creatine kinase levels in normal females. J Med Genet. 1979 Feb;16(1):49–51. doi: 10.1136/jmg.16.1.49. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Sheffer A. L., Fearon D. T., Austen K. F. Clinical and biochemical effects of stanozolol therapy for hereditary angioedema. J Allergy Clin Immunol. 1981 Sep;68(3):181–187. doi: 10.1016/0091-6749(81)90181-0. [DOI] [PubMed] [Google Scholar]
  28. Shumate J. B., Brooke M. H., Carroll J. E., Davis J. E. Increased serum creatine kinase after exercise: a sex-linked phenomenon. Neurology. 1979 Jun;29(6):902–904. doi: 10.1212/wnl.29.6.902. [DOI] [PubMed] [Google Scholar]
  29. Sweetin J. C., Thomson W. H. Revised normal ranges for six serum enzymes: further statistical analysis and the effects of different treatments of blood specimens. Clin Chim Acta. 1973 Sep 28;48(1):49–63. doi: 10.1016/0009-8981(73)90217-9. [DOI] [PubMed] [Google Scholar]
  30. Thomson W. H. An investigation of physical factors influencing the behaviour in vitro of serum creatine phosphokinase and other enzymes. Clin Chim Acta. 1969 Jan;23(1):105–120. doi: 10.1016/0009-8981(69)90017-5. [DOI] [PubMed] [Google Scholar]
  31. VEJJAJIVA A., TEASDALE G. M. SERUM CREATINE KINASE AND PHYSICAL EXERCISE. Br Med J. 1965 Jun 26;1(5451):1653–1654. doi: 10.1136/bmj.1.5451.1653. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Van Steirteghem A. C., Robertson E. A., Zweig M. H. Distribution of serum concentrations of creatine kinase MM and BB isoenzymes measured by radioimmunoassay. Clin Chim Acta. 1979 Apr 2;93(1):25–28. doi: 10.1016/0009-8981(79)90240-7. [DOI] [PubMed] [Google Scholar]
  33. Wong E. T., Cobb C., Umehara M. K., Wolff G. A., Haywood L. J., Greenberg T., Shaw S. T., Jr Heterogeneity of serum creatine kinase activity among racial and gender groups of the population. Am J Clin Pathol. 1983 May;79(5):582–586. doi: 10.1093/ajcp/79.5.582. [DOI] [PubMed] [Google Scholar]

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