Abstract
A patient is described who presented with painful feet on exercise. He had no evidence of peripheral vascular disease but did have anhidrosis and failure of vasodilatation in the hands and feet suggesting peripheral dysautonomia. Examination of his mother and a cousin and clinical histories of blood relatives suggested that his problem was a severe presentation of a familial distal dysautonomia. In other family members this was represented by dry hands and feet and variable vasomotor symptoms. This condition appeared to be autosomal dominant.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Axelrod F. B., Pearson J. Congenital sensory neuropathies. Diagnostic distinction from familial dysautonomia. Am J Dis Child. 1984 Oct;138(10):947–954. [PubMed] [Google Scholar]
- BARANY F. R., COOPER E. H. Pilomotor and sudomotor innervation in diabetes. Clin Sci. 1956 Nov;15(4):533–540. [PubMed] [Google Scholar]
- BENNETT P. H., SCOTT J. T. AUTONOMIC NEUROPATHY IN RHEUMATOID ARTHRITIS. Ann Rheum Dis. 1965 Mar;24:161–168. doi: 10.1136/ard.24.2.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
- COOPER K. E., JOHNSON R. H., SPALDING J. M. THE EFFECTS OF CENTRAL BODY AND TRUNK SKIN TEMPERATURES ON REFLEX VASODILATATION IN THE HAND. J Physiol. 1964 Oct;174:46–54. doi: 10.1113/jphysiol.1964.sp007473. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cancer campaign: cash and compassion. Br Med J. 1973 Jul 14;3(5871):61–62. [PMC free article] [PubMed] [Google Scholar]
- Coffman J. D., Cohen R. A. Cholinergic vasodilator mechanism in human fingers. Am J Physiol. 1987 Mar;252(3 Pt 2):H594–H597. doi: 10.1152/ajpheart.1987.252.3.H594. [DOI] [PubMed] [Google Scholar]
- Dyck P. J., Low P. A., Stevens J. C. "Burning feet" as the only manifestation of dominantly inherited sensory neuropathy. Mayo Clin Proc. 1983 Jul;58(7):426–429. [PubMed] [Google Scholar]
- Faerman I., Faccio E., Calb I., Razumny J., Franco N., Dominguez A., Podestá H. A. Autonomic neuropathy in the skin: a histological study of the sympathetic nerve fibres in diabetic anhidrosis. Diabetologia. 1982 Feb;22(2):96–99. doi: 10.1007/BF00254836. [DOI] [PubMed] [Google Scholar]
- Guiloff R. J., Sherratt R. M. Sensory conduction in medial plantar nerve: normal values, clinical applications, and a comparison with the sural and upper limb sensory nerve action potentials in peripheral neuropathy. J Neurol Neurosurg Psychiatry. 1977 Dec;40(12):1168–1181. doi: 10.1136/jnnp.40.12.1168. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jestico J. V., Urry P. A., Efphimiou J. An hereditary sensory and autonomic neuropathy transmitted as an X-linked recessive trait. J Neurol Neurosurg Psychiatry. 1985 Dec;48(12):1259–1264. doi: 10.1136/jnnp.48.12.1259. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KARNOVSKY M. J., ROOTS L. A "DIRECT-COLORING" THIOCHOLINE METHOD FOR CHOLINESTERASES. J Histochem Cytochem. 1964 Mar;12:219–221. doi: 10.1177/12.3.219. [DOI] [PubMed] [Google Scholar]
- LEWIS P. FAMILIAL ORTHOSTATIC HYPOTENSION. Brain. 1964 Dec;87:719–728. doi: 10.1093/brain/87.4.719. [DOI] [PubMed] [Google Scholar]
- Low P. A., Walsh J. C., Huang C. Y., McLeod J. G. The sympathetic nervous system in alcoholic neuropathy. A clinical and pathological study. Brain. 1975 Sep;98(3):357–364. doi: 10.1093/brain/98.3.357. [DOI] [PubMed] [Google Scholar]
- Macmillan A. L., Spalding J. M. Human sweating response to electrophoresed acetylcholine: a test of postganglionic sympathetic function. J Neurol Neurosurg Psychiatry. 1969 Apr;32(2):155–160. doi: 10.1136/jnnp.32.2.155. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SWANSON A. G. Congenital insensitivity to pain with anhydrosis. A unique syndrome in two male siblings. Arch Neurol. 1963 Mar;8:299–306. doi: 10.1001/archneur.1963.00460030083008. [DOI] [PubMed] [Google Scholar]