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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1989 Nov;52(11):1294–1295. doi: 10.1136/jnnp.52.11.1294

People with Down's syndrome can be distinguished on the basis of cholinergic dysfunction.

B Sacks 1, S Smith 1
PMCID: PMC1031641  PMID: 2531786

Abstract

The mydriatic response to eyedrops of the anticholinergic agent tropicamide at very low concentration (0.01%) has been studied in people with Down's syndrome. By comparison with healthy subjects people with Down's syndrome had responses approximately three times greater, suggesting a peripheral imbalance between cholinergic and adrenergic autonomic influences.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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