Error in Figure/Table
In the published article, there was an error in [Table 1 Search strategies] as published. [We had searched PubMed for the first set of results in Table 1 and not PubMed-MEDLINE]. The corrected caption in [Table 1 Search strategies] is **[PubMed] which appears below.
PubMed
In the published article, there was an error in [Table 2 Characteristics of included studies in the meta-analysis]. The corrected [Table 2 Characteristics of included studies in the meta-analysis] and its caption **[Table 2 Characteristics of included studies in the meta-analysis] appear below.
Table 2.
Characteristics of included studies in the meta-analysis.
| Author/Year | Place of study | Type of study | PCOS vs. control (n) | Participants age | BMI | WHR | Androgen level | Outcomes |
|---|---|---|---|---|---|---|---|---|
| Akram (2010) | Pakistan | Retrospective | 50 vs. 30 | 20–39 years | PCOS: 23.6 ± 0.50 kg/m2; Control: 23.5 ± 0.71 kg/m2 |
– | – | HDL-C, LDL-C, TG, nonHDL-C |
| Adali (2010) | Turkey | Prospective | 26 vs. 25 | PCOS: 24.73 ± 2.91 years; Control: 25.04 ± 2.26 years |
PCOS: 24.40 ± 4.23 kg/m2; Control: 23.90 ± 3.95 kg/m2 |
PCOS: 0.74 ± 0.05; Control: 0.73 ± 0.04 | – | HDL-C, LDL-C, TG, SBP, DBP, nonHDL-C |
| Alexandraki (2006) | Greece | Cross-section | 27 vs. 27 | PCOS: 25.41 ± 0.80 years; Control: 27.33 ± 0.83 years | PCOS: 27.42 ± 1.12 kg/m2; Control: 25.05 ± 1.19 kg/m2 |
PCOS: 0.78 ± 0.01; Control: 0.75 ± 0.01 | PCOS: 10.85 ± 0.76 nmol/L; Control: 5.37 ± 0.38 nmol/L |
HDL-C, LDL-C, TG, nonHDL-C, SBP, DBP |
| Arikan (2007) | Turkey | Prospective | 39 vs. 30 | PCOS: 22.82 ± 5.53 years; Control: 24.64 ± 4.22 years |
PCOS: 21.48 ± 6.50 kg/m2; Control: 20.90 ± 6.04 kg/m2 |
– | PCOS: 2.98 ± 1.31 ng/ml; Control: 1.37 ± 0.89 ng/ml |
HDL-C, LDL-C, TG, nonHDL-C |
| Berneis (2009) | Italy | Cross-section | 30 vs. 24 | PCOS: 25.1 ± 4.2 years; Control: 25.5 ± 3 years |
PCOS: 28.4 ± 5.8 kg/m2; Control: 28 ± 4.4 kg/m2 |
– | – | HDL-C, LDL-C, TG, nonHDL-C |
| Cascella (2006) | Italy | Prospective | 50 vs. 50 | PCOS: 21.9 ± 2.7 years; Control: 22.2 ± 2.8 years |
PCOS: 24.6 ± 2.5 kg/m2; Control: 24.4 ± 2.8 kg/m2 |
PCOS: 0.86 ± 0.1; Control: 0.83 ± 0.1 | PCOS: 5.1 ± 0.7 nmol/L; Control: 1.4 ± 0.6 nmol/L |
HDL-C, LDL-C, TG, SBP, DBP, nonHDL-C |
| Calzada (2018) | Spain | Retrospective | 125 vs. 169 | PCOS: 28.0 ± 5.0 years; Control: 30.0 ± 6.0 years |
PCOS: 25.7 ± 7.1 kg/m2; Control: 22.3 ± 3.1 kg/m2 |
– | PCOS: 2.73 ± 1.35 ng/ml; Control: 2.17 ± 1.05 ng/ml |
HDL-C, LDL-C, TG, SBP, DBP, nonHDL-C |
| Cetinkalp (2009) | Turkey | Prospective | 129 vs. 91 | PCOS: 24.58 ± 4.61 years; Control: 25.48 ± 3.38 years |
PCOS: 24.47 ± 4.64 kg/m2; Control: 24.20 ± 3.31 kg/m2 |
– | – | HDL-C, LDL-C, TG, nonHDL-C |
| Cheng (2015) | China | Prospective | 103 vs. 96 | PCOS: 26 ± 4 years; Control: 26 ± 2 years |
PCOS: 24.2 ± 5.3 kg/m2 Control: 20.5 ± 2.7 kg/m2 |
PCOS: 0.9 ± 0.3; Control: 0.8 ± 0.1 | – | HDL-C, LDL-C, TG, SBP, DBP, nonHDL-C |
| Cussons (2009) | Australia | Cross-section | 19 vs. 19 | PCOS: 30.4 ± 5.54 years; Control: 34.44 ± 7.8 years |
PCOS: 24.1 ± 2.9 kg/m2 Control: 22.9 ± 3.2 kg/m2 |
PCOS: 0.8 ± 0.1; Control: 0.8 ± 0.6 | PCOS: 10.89 ± 3.99 nmol/L; Control: 8.54 ± 2.41 nmol/L |
HDL-C, LDL-C, TG, SBP, DBP, nonHDL-C |
| Diamanti-Kandarakis (2006) | Greece | Prospective | 25 vs. 25 | PCOS: 25.64 ± 0.86 years; Control: 27.52 ± 1.02 years |
PCOS: 29.08 ± 1.43 kg/m2; Control: 26.22 ± 1.16 kg/m2 |
PCOS: 0.79 ± 0.01; Control: 0.75 ± 0.01 | – | HDL-C, SBP, DBP, nonHDLC |
| El-Kannishy (2010) | Egypt | Cross-section | 14 vs. 10 | PCOS: 25.2 ± 3.6 years; Control: 24.4 ± 4.07 years |
PCOS: 22.8 ± 2.1 kg/m2 Control: 21.9 ± 2.97 kg/m2 |
– | – | HDL-C, LDL-C, TG, nonHDL-C |
| Erdogan (2007) | USA | Retrospective | 68 vs. 26 | PCOS: 24.27 ± 5.44 years; Control: 26.41 ± 5.65 years |
PCOS: 24.41 ± 5.43 kg/m2 Control: 23.35 ± 5.04 kg/m2 |
– | – | HDL-C, LDL-C, TG, nonHDL-C |
| Erdogan (2009) | USA | Retrospective | 88 vs. 119 | PCOS: 24.07 ± 1.32 years; Control: 25.01 ± 2.05 years | PCOS: 24.38 ± 4.13 kg/m2 Control: 23.47 ± 4.12 kg/m2 |
– | – | HDL-C, LDL-C, TG, nonHDL-C |
| Glintborg (2013) | Denmark | Prospective | 30 vs. 14 | PCOS: 32.3 ± 7.9 years; Control: 34.3 ± 12.4 years |
PCOS: 33.5 ± 4.2 kg/m2; Control: 32.8 ± 7.1 kg/m2 |
– | – | TG |
| Gonzalez (2020) | USA | Cross-section | Lean: 10 vs. 10; Obese: 9 vs. 9 | Lean: PCOS: 27 ± 1 years; Control: 29 ± 2 years; Obese: PCOS: 28 ± 2 years; Control: 32 ± 2 years |
Lean: PCOS: 22.5 ± 0.6 kg/m2; Control: 22.0 ± 0.8 kg/m2; Obese: PCOS: 34.4 ± 0.9 kg/m2; Control: 34.1 ± 0.7 kg/m2 |
– | Lean: PCOS: 4.1 ± 0.4 ng/ml; Control: 1.8 ± 0.8 ng/ml; Obese: PCOS: 3.8 ± 0.3 ng/ml; Control: 2.0 ± 0.2 ng/ml |
HDL-C, LDL-C, TG, SBP, DBP, nonHDL-C |
| Kargili (2010) | Turkery | Cross-section | 168 vs. 52 | PCOS: 25.7 ± 5.5 years; Control: 26.1 ± 5.4 years |
PCOS: 26.8 ± 3.4 kg/m2; Control: 25.4 ± 2.8 kg/m2 |
– | – | HDL-C, LDL-C, TG, SBP, DBP, nonHDL-C |
| Ketel (2010) | Netherlands | Cross-section | Lean: 22 vs. 17 Obese: 18 vs. 13 |
Lean: PCOS: 28.6 ± 4.5 years; Control: 27.7 ± 5.3 years; Obese: PCOS: 30.3 ± 4.2 years; Control: 28.6 ± 5.3 years |
Lean: PCOS: 22.0 ± 2.2 kg/m2; Control: 22.2 ± 1.7 kg/m2; Obese: PCOS: 36.2 ± 5.9 kg/m2; Control: 40.5 ± 7.0 kg/m2 |
Lean: PCOS: 0.78 ± 0.05; Control: 0.76 ± 0.03; Obese: PCOS: 0.84 ± 0.05; Control: 0.80 ± 0.01 |
Lean: PCOS: 7.0 ± 1.8 nmol/L; Control: 4.8 ± 1.2 nmol/L; Obese: PCOS: 7.7 ± 2.4 nmol/L; Control: 4.9 ± 1.7 nmol/L |
HDL-C, LDL-C, TG, SBP, DBP, nonHDL-C |
| Legro (2001) | USA | Cross-section | Lean: 42 vs. 27; Obese: 153 vs. 35 | Lean: PCOS: 25 ± 6 years; Control: 29 ± 7 years; Obese: PCOS: 28 ± 5 years; Control: 32 ± 7 years |
Lean: PCOS: 23.1 ± 2.4 kg/m2; Control: 23.0 ± 1.8 kg/m2; Obese: PCOS: 37.0 ± 6.9 kg/m2; Control: 37.7 ± 6.4 kg/m2 |
Lean: PCOS: 0.76 ± 0.07; Control: 0.75 ± 0.06; Obese: PCOS: 0.85 ± 0.10; Control: 0.79 ± 0.06 |
Lean: PCOS: 2,553 ± 1,367 ng/ml; Control: 1,628 ± 734 ng/ml; Obese: PCOS: 2,476 ± 1,140 ng/ml; Control: 1,533 ± 720 ng/mla |
HDL-C, LDL-C, TG, SBP, DBP, nonHDL-C |
| Liang (2012) | Taiwan | Prospective | Lean: 110 vs. 50; Obese: 110 vs. 20 | Lean: PCOS: 26.8 ± 5.1 years; Control: 28.1 ± 4.2 years Obese: PCOS: 27.0 ± 6.4 years; Control: 29.0 ± 5.1 years |
Lean: PCOS: 20.6 ± 2.0 kg/m2; Control: 20.4 ± 2.0 kg/m2; Obese: PCOS: 31.1 ± 3.9 kg/m2; Control: 30.4 ± 3.7 kg/m2 |
Lean: PCOS: 0.79 ± 0.06; Control: 0.82 ± 0.14; Obese: PCOS: 0.89 ± 0.08; Control: 0.85 ± 0.08 |
– | HDL-C, LDL-C, TG, nonHDL-C |
| Long (2019) | China | Cross-section | 387 vs. 150 | PCOS: 27.0 ± 4.5 years; Control: 25.3 ± 2.2 years |
PCOS: 25.4 ± 4.6 kg/m2; Control: 20.7 ± 2.6 kg/m2 |
PCOS: 0.86 ± 0.06; Control: 0.80 ± 0.07 | – | HDL-C, LDL-C, TG, SBP, DBP, nonHDL-C |
| Luque-Ramirez (2007) | Spain | Cross-section | Lean: 11 vs. 8; Overweight: 13 vs. 4; Obese: 16 vs. 8 | Lean: PCOS: 23.0 ± 5.4 years; Control: 24.8 ± 6.0 years; Overweight: PCOS: 23.6 ± 4.6 years; Control: 29.3 ± 10.3 years; Obese: PCOS: 26.3 ± 6.7 years; Control: 28.5 ± 5.8 years |
Lean: PCOS: 22.2 ± 2.0 kg/m2; Control: 21.3 ± 1.3 kg/m2; Overweight: PCOS: 27.5 ± 1.8 kg/m2; Control: 27.4 ± 1.5 kg/m2 Obese: PCOS: 35.8 ± 3.9 kg/m2; Control: 35.5 ± 3.2 kg/m2 |
Lean: PCOS: 0.73 ± 0.06; Control: 0.73 ± 0.06; Overweight: PCOS: 0.79 ± 0.07; Control: 0.79 ± 0.04; Obese: PCOS: 0.88 ± 0.09; Control: 0.83 ± 0.08 |
PCOS: 12.7 ± 3.6 nmol/L; Control: 7.2 ± 2.2 nmol/L |
HDL-C, LDL-C, TG, SBP, DBP, nonHDL-C |
| Macut (2008) | Serbia | Prospective | 75 vs. 51 | PCOS: 23.1 ± 5.1 years; Control: 24.6 ± 4.1 years |
PCOS: 24.9 ± 4.7 kg/m2; Control: 23.7 ± 4.0 kg/m2 |
PCOS: 0.79 ± 0.06; Control: 0.77 ± 0.05 | – | HDL-C, LDL-C, TG, nonHDL-C |
| Meyer (2005) | Australia | Retrospective | 100 vs. 20 | PCOS: 32.7 ± 1.8 years; Control: 33.2 ± 2.3 years |
PCOS: 37.3 ± 2.43 kg/m2; Control: 36.7 ± 1.28 kg/m2 |
PCOS: 0.86 ± 0.01; Control: 0.84 ± 0.02 | PCOS: 4.9 ± 0.3 mmol/L; Control: 3.6 ± 0.4 mmol/La |
HDL-C, LDL-C, TG, SBP, DBP, nonHDL-C |
| Moran (2009) | Australia | Cross-section | 80 vs. 27 | PCOS: 34.1 ± 6.9 years; Control: 33.8 ± 6.8 years |
PCOS: 36.0 ± 6.6 kg/m2; Control: 37.4 ± 5.6 kg/m2 |
PCOS: 0.86 ± 0.08; Control: 0.84 ± 0.06 | PCOS: 4.8 ± 0.3 µmol/L; Control: 3.4 ± 0.4 µmol/La |
HDL-C, LDL-C, TG, nonHDL-C |
| Ni (2009) | China | Retrospective | 578 vs. 281 | PCOS: 27.3 ± 3.7 years; Control: 28.3 ± 3.7 years |
PCOS: 22.1 ± 3.7 kg/m2; Control: 22.2 ± 2.2 kg/m2 |
– | PCOS: 5.4 ± 2.5 µmol/L; Control: 4.4 ± 1.9 µmol/La |
TG, SBP, DBP |
| Oral (2009) | Turkey | Prospective | 48 vs. 43 | PCOS: 23.9 ± 3.3 years; Control: 24.2 ± 3.9 years |
PCOS: 24.1 ± 2.9 kg/m2; Control: 24.0 ± 1.9 kg/m2 |
– | PCOS: 256.3 ± 59.5 µg/dl; Control: 246.5 ± 59.5 µg/dla |
HDL-C, LDL-C, TG, nonHDL-C |
| Orio (2004) | Italy | Prospective | 30 vs. 30 | PCOS: 22.2 ± 2.5 years; Control: 22.6 ± 2.3 years |
PCOS: 22.4 ± 2.1 kg/m2; Control: 22.1 ± 1.8 kg/m2 |
PCOS: 0.77 ± 0.4; Control: 0.72 ± 0.3 | PCOS: 4,535 ± 527 µmol/L; Control: 2,988 ± 311 µmol/La |
HDL-C, LDL-C, TG, SBP, DBP, nonHDL-C, |
| Philbois (2019) | Brazil | Retrospective | 60 vs. 30 | PCOS without obese: 28.5 ± 5.2 years; PCOS without obese: 30.2 ± 5.3 years; Control: 31.2 ± 6.6 years | PCOS without obese: 22.9 ± 1.6 kg/m2; PCOS with obese: 33.9 ± 2.4 kg/m2; Control: 23.5 ± 3 kg/m2 | – | – | SBP, DBP |
| Rizzo (2011) | Italy | Prospective | 350 vs. 90 | PCOS: 24 ± 5 years; Control: 24 ± 3 years |
PCOS: 27 ± 7 kg/m2; Control: 27 ± 4 kg/m2 | – | – | HDL-C, LDL-C, TG, nonHDL-C |
| Sasaki (2011) | Japan | Prospective | 54 vs. 24 | PCOS: 30.2 ± 3.9 years; Control: 31.5 ± 4.4 years | PCOS: 24.3 ± 5.7 kg/m2; Control: 22.2 ± 3.4 kg/m2 |
– | – | HDL-C, LDL-C, TG, SBP, DBP, nonHDL-C |
| Shafiee (2020) | UK | Cross-section | 34 vs. 34 | PCOS: 31.8 ± 5.97 years; Control: 43.68 ± 13.12 years | PCOS: 29.28 ± 2.91 kg/m2; Control: 28.58 ± 2.62 kg/m2 |
PCOS: 0.88 ± 0.03; Control: 0.85 ± 0.02 | – | HDL-C, LDL-C, TG, SBP, DBP, nonHDL-C |
| Shroff (2007) | USA | Prospective | 24 vs. 24 | PCOS: 32 ± 6.5 years; Control: 36 ± 7.2 years |
PCOS: 36 ± 5.4 kg/m2; Control: 35 ± 3.3 kg/m2 |
PCOS: 0.85 ± 0.1; Control: 0.82 ± 0.1 | – | HDL-C, LDL-C, TG |
| Soares (2009) | Brazil | Cross-section | 40 vs. 50 | PCOS: 24.5 ± 3.8 years; Control: 24.5 ± 5.1 years |
PCOS: 22.7 ± 3.3 kg/m2; Control: 23.1 ± 3.2 kg/m2 |
– | – | HDL-C, LDL-C, TG, SBP, DBP, nonHDL-C |
| Tarkun (2004) | Turkey | Prospective | 37 vs. 25 | PCOS: 23.45 ± 4.3 years; Control: 24.4 ± 4.07 years | PCOS: 23.85 ± 3.26 kg/m2; Control: 22.9 ± 2.97 kg/m2 |
– | PCOS: 4.08 ± 2.3 ng/ml; Control: 2.89 ± 1.1 ng/ml |
HDL-C, LDL-C, TG, nonHDL-C |
| Tiras (1999) | Turkey | Prospective | 35 vs. 35 | PCOS: 24.5 ± 6.0 years; Control: 23.6 ± 3.9 years |
PCOS: 22.9 ± 4.2 kg/m2; Control: 22.0 ± 1.8 kg/m2 |
– | PCOS: 4.05 ± 3.14 ng/ml; Control: 2.48 ± 0.98 ng/ml |
HDL-C, LDL-C, TG, nonHDL-C |
| Vryonidou (2005) | Greece | Prospective | 75 vs. 55 | PCOS: 23.9 ± 5.4 years; Control: 24.7 ± 5.3 years |
PCOS: 27.3 ± 7.0 kg/m2; Control: 26.3 ± 7.7 kg/m2 |
PCOS: 0.79 ± 0.07; Control: 0.75 ± 0.04 | PCOS: 8.12 ± 9.11 µmol/L; Control: 6.54 ± 8.59 µmol/La |
HDL-C, LDL-C, TG, SBP, nonHDL-C |
| Yildiz (2002) | Turkey | Prospective | 59 vs. 23 | PCOS: 22.9 ± 4.4 years; Control: 24.8 ± 4.2 years |
PCOS: 23.0 ± 2.4 kg/m2; Control: 22.1 ± 2.2 kg/m2 |
PCOS: 0.76 ± 0.02; Control: 0.71 ± 0.02 | PCOS: 9.4 ± 3.1 nmol/L; Control: 5.9 ± 1.7 nmol/L |
HDL-C, TG, nonHDL-C |
Represented that these studies measured the level of dehydroepiandrosterone sulfate, others measured androstenedione level. WHR: Waist-to-hip ratio; BMI: Body mass index; LDL-C: low-density lipoprotein cholesterol; TG: triglyceride; HDL-C: low high-density lipoprotein cholesterol; SBP: Systolic blood pressure; DBP: Diastolic blood pressure.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
In the published article, there was an error in (Figure 4) as published. [We have revised Figure 4, in which we had included an incorrect study]. The corrected [Figure 4] and its caption **[Forest plot for comparison of non-high-density lipoprotein-cholesterol in polycystic ovary syndrome vs. control subjects. Studies are classified by different body mass index (BMI) categories (BMI < 25 kg/m2, BMI ≥ 30 kg/m2, and BMI 25–30 kg/m2).] appear above.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
Text Correction
In the published article, there was two errors in the method.
1. According to the corrected figure, we revised the result of non-HDL-C].
An error was found in [Methods], [Study selection and criteria], [Page 2]. This sentence previously stated:
“[(4) articles published in languages other than English]” This sentence should be deleted.
2. [The selection criteria for the retrieved articles was unclear in the sixth information].
A correction has been made to [Methods], [Study selection and criteria], [Page 2]. This sentence previously stated:
“[6) each article had to conduct BMI matching]”
The corrected sentence appears below: 6) each article had to conduct BMI matching or the equal BMI (mean)
A correction has been made to [Results], [Lipid profiles], [Page 8]. This sentence previously stated:
“[As shown in Figure 4, non-HDL-C [SMD (95% CI): 0.42 (0.31, 0.52), P < 0.001] increased in reproductive-aged women with PCOS, with significant between-study heterogeneity. The subgroup analysis showed that non-HDL-C increased in women with PCOS at the three BMI levels, including BMI < 25 kg/m2 [SMD (95% CI): 0.40 (0.27, 0.54), P < 0.001], BMI ≥ 30 kg/m2 [MD (95% CI): 0.52 (0.33, 0.70), P < 0.001], and BMI 25–30 kg/m2 [MD (95% CI): 0.37 (0.11, 0.62), P = 0.005]. In this analysis, no publication bias was evident (asymmetry test P = 0.291).]”
The corrected sentence appears below:
“[As shown in Figure 4, non-HDL-C [SMD (95% CI): 0.42 (0.31, 0.53), P < 0.001] increased in reproductive-aged women with PCOS, with significant between-study heterogeneity. The subgroup analysis showed that non-HDL-C increased in women with PCOS at the three BMI levels, including BMI < 25 kg/m2 [SMD (95% CI): 0.40 (0.27, 0.54), P < 0.001], BMI ≥ 30 kg/m2 [MD (95% CI): 0.57 (0.37, 0.77), P < 0.001], and BMI 25–30 kg/m2 [MD (95% CI): 0.37 (0.11, 0.62), P = 0.005].]”
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.