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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1989 Oct;52(10):1194–1196. doi: 10.1136/jnnp.52.10.1194

Soluble class I antigens in serum and CSF of patients with varicella-zoster virus meningitis.

J Alvarez-Cermeño 1, J M Echevarría 1, L M Villar 1, I Lázaro 1, A Bootello 1, P González-Porque 1
PMCID: PMC1031708  PMID: 2552020

Abstract

Soluble class I antigens (sHLA) are secreted by lymphocytes upon activation in vitro. The intrathecal synthesis (ITS) of these molecules has been studied in patients with the varicella-zoster virus (VZV) meningitis. In this paper we describe a sHLA index IH = (CSF sHLA/serum sHLA): (CSF albumin/serum albumin) which is expected to increase only when sHLA is synthesised within the central nervous system (CNS). The IH is elevated in the first week of meningitis, when antibody synthesis is still low, and decreases thereafter. We think IH is an index of early lymphocyte activation within the CNS. The relation of these findings with previous in vitro studies is also discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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