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. 1989 Sep;52(9):1110–1112. doi: 10.1136/jnnp.52.9.1110

Intrathecal baclofen and the H-reflex.

R A Macdonell 1, A Talalla 1, M Swash 1, D Grundy 1
PMCID: PMC1031752  PMID: 2795085

Abstract

Baclofen was given intrathecally to six patients with severe lower limb spasticity due to traumatic spinal cord injury. The effects of the drug on spasticity and the ratio between the maximum amplitude of the H reflex and the M response from the soleus (Hmax/Mmax ratio) were assessed. In each patient, spasticity was reduced following intrathecal baclofen and in four patients there was a reduction in the amplitude of the H reflex and Hmax/Mmax ratio. These results suggest that the Hmax/Mmax ratio may be helpful in establishing optimum drug dosage, particularly when the drug is used on a chronic basis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANGEL R. W., HOFMANN W. W. THE H REFLEX IN NORMAL, SPASTIC, AND RIGID SUBJECTS. Arch Neurol. 1963 Jun;9:591–596. doi: 10.1001/archneur.1963.00460060021002. [DOI] [PubMed] [Google Scholar]
  2. ASHWORTH B. PRELIMINARY TRIAL OF CARISOPRODOL IN MULTIPLE SCLEROSIS. Practitioner. 1964 Apr;192:540–542. [PubMed] [Google Scholar]
  3. Ashby P., White D. G. "Presynaptic" inhibition in spasticity and the effect of beta(4-chlorophenyl)GABA. J Neurol Sci. 1973 Nov;20(3):329–338. doi: 10.1016/0022-510x(73)90194-9. [DOI] [PubMed] [Google Scholar]
  4. Birkmayer W., Danielczyk W., Weiler G. Zur Objektivierbarkeit des myotonolytischen Effektes eines Aminobuttersäurederivates (CIBA 34647-Ba) Wien Med Wochenschr. 1967 Jan 7;117(1):7–9. [PubMed] [Google Scholar]
  5. Corston R. N., Johnson F., Godwin-Austen R. B. The assessment of drug treatment of spastic gait. J Neurol Neurosurg Psychiatry. 1981 Nov;44(11):1035–1039. doi: 10.1136/jnnp.44.11.1035. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Davidoff R. A. Antispasticity drugs: mechanisms of action. Ann Neurol. 1985 Feb;17(2):107–116. doi: 10.1002/ana.410170202. [DOI] [PubMed] [Google Scholar]
  7. Landau W. M. Editorial: Spasticity: the fable of a neurological demon and the emperor's new therapy. Arch Neurol. 1974 Oct;31(4):217–219. doi: 10.1001/archneur.1974.00490400031001. [DOI] [PubMed] [Google Scholar]
  8. MAGLADERY J. W., TEASDALL R. D., PARK A. M., LANGUTH H. W. Electrophysiological studies of reflex activity in patients with lesions of the nervous system. I. A comparison of spinal motoneurone excitability following afferent nerve volleys in normal persons and patients with upper motor neurone lesions. Bull Johns Hopkins Hosp. 1952 Oct;91(4):219–passim. [PubMed] [Google Scholar]
  9. Matthews W. B. Ratio of maximum H reflex to maximum M response as a measure of spasticity. J Neurol Neurosurg Psychiatry. 1966 Jun;29(3):201–204. doi: 10.1136/jnnp.29.3.201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Pedersen E., Arlien-Soborg P., Mai J. The mode of action of the gaba derivative baclofen in human spasticy. Acta Neurol Scand. 1974;50(6):665–680. doi: 10.1111/j.1600-0404.1974.tb02813.x. [DOI] [PubMed] [Google Scholar]
  11. Penn R. D., Kroin J. S. Continuous intrathecal baclofen for severe spasticity. Lancet. 1985 Jul 20;2(8447):125–127. doi: 10.1016/s0140-6736(85)90228-4. [DOI] [PubMed] [Google Scholar]
  12. Penn R. D., Kroin J. S. Long-term intrathecal baclofen infusion for treatment of spasticity. J Neurosurg. 1987 Feb;66(2):181–185. doi: 10.3171/jns.1987.66.2.0181. [DOI] [PubMed] [Google Scholar]
  13. Young R. R., Delwaide P. J. Drug therapy: spasticity (second of two parts). N Engl J Med. 1981 Jan 8;304(2):96–99. doi: 10.1056/NEJM198101083040207. [DOI] [PubMed] [Google Scholar]

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