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. 1987 Mar;50(3):345–348. doi: 10.1136/jnnp.50.3.345

Juvenile Parkinsonism: clinical and metabolic characteristics.

B Lima, G Neves, M Nora
PMCID: PMC1031801  PMID: 3559615

Abstract

Twenty one patients with idiopathic Parkinsonism beginning before the age of 40 years were investigated. The mean duration of the disease was 19 years. There was a good and sustained response to levodopa. Only four patients reached stages IV and V (Hoehn and Yahr). Intolerance to levodopa was observed in the more advanced stages of the disease. In the series the familial incidence of Parkinsonism (2 cases) and essential tremor (3 cases) was very low. Thyroid disorder, diabetes mellitus or macrocytic anaemia was not found in any of the cases.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BITTENBENDER J. B., QUADFASEL F. A. Rigid and akinetic forms of Huntington's chorea. Arch Neurol. 1962 Oct;7:275–288. doi: 10.1001/archneur.1962.04210040027003. [DOI] [PubMed] [Google Scholar]
  2. Barbeau A., Pourcher E. New data on the genetics of Parkinson's disease. Can J Neurol Sci. 1982 Feb;9(1):53–60. doi: 10.1017/s031716710004364x. [DOI] [PubMed] [Google Scholar]
  3. Barbeau A., Roy M. Familial subsets in idiopathic Parkinson's disease. Can J Neurol Sci. 1984 Feb;11(1 Suppl):144–150. doi: 10.1017/s0317167100046308. [DOI] [PubMed] [Google Scholar]
  4. Berciano J. Olivopontocerebellar atrophy. A review of 117 cases. J Neurol Sci. 1982 Feb;53(2):253–272. doi: 10.1016/0022-510x(82)90011-9. [DOI] [PubMed] [Google Scholar]
  5. Bird M. T., Paulson G. W. Early onset rigid Huntington's disease. Neurology. 1970 Apr;20(4):400–400. [PubMed] [Google Scholar]
  6. Brannan T. S., Burger A. A., Chaudhary M. Y. Bilateral basal ganglia calcifications visualised on CT scan. J Neurol Neurosurg Psychiatry. 1980 May;43(5):403–406. doi: 10.1136/jnnp.43.5.403. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Carlier G., Dubru J. M. Familial juvenile Parkinsonism. Acta Paediatr Belg. 1979 Apr-Jun;32(2):123–127. [PubMed] [Google Scholar]
  8. Coutinho P., Andrade C. Autosomal dominant system degeneration in Portuguese families of the Azores Islands. A new genetic disorder involving cerebellar, pyramidal, extrapyramidal and spinal cord motor functions. Neurology. 1978 Jul;28(7):703–709. doi: 10.1212/wnl.28.7.703. [DOI] [PubMed] [Google Scholar]
  9. DAVISON C. Pallido-pyramidal disease. J Neuropathol Exp Neurol. 1954 Jan;13(1):50–59. doi: 10.1097/00005072-195401000-00007. [DOI] [PubMed] [Google Scholar]
  10. DUVOISIN R. C., YAHR M. D. ENCEPHALITIS AND PARKINSONISM. Arch Neurol. 1965 Mar;12:227–239. doi: 10.1001/archneur.1965.00460270003001. [DOI] [PubMed] [Google Scholar]
  11. HIRANO A., KURLAND L. T., KROOTH R. S., LESSELL S. Parkinsonism-dementia complex, an endemic disease on the island of Guam. I. Clinical features. Brain. 1961 Dec;84:642–661. doi: 10.1093/brain/84.4.642. [DOI] [PubMed] [Google Scholar]
  12. HIRANO A., MALAMUD N., KURLAND L. T. Parkinsonism-dementia complex, an endemic disease on the island of Guam. II. Pathological features. Brain. 1961 Dec;84:662–679. doi: 10.1093/brain/84.4.662. [DOI] [PubMed] [Google Scholar]
  13. Herishanu Y., Noah Z. On acute encephalitic parkinsonian syndrome. Case report and review of the recent literature. Eur Neurol. 1973;10(2):117–124. doi: 10.1159/000114268. [DOI] [PubMed] [Google Scholar]
  14. Hoehn M. M., Yahr M. D. Parkinsonism: onset, progression and mortality. Neurology. 1967 May;17(5):427–442. doi: 10.1212/wnl.17.5.427. [DOI] [PubMed] [Google Scholar]
  15. Klawans H. L., Lupton M., Simon L. Calcification of the basal ganglia as a cause of levodopa-resistant parkinsonism. Neurology. 1976 Mar;26(3):221–225. doi: 10.1212/wnl.26.3.221. [DOI] [PubMed] [Google Scholar]
  16. Koller W. C., Cochran J. W., Klawans H. L. Calcification of the basal ganglia: computerized tomography and clinical correlation. Neurology. 1979 Mar;29(3):328–333. doi: 10.1212/wnl.29.3.328. [DOI] [PubMed] [Google Scholar]
  17. Martin W. E., Resch J. A., Baker A. B. Juvenile parkinsonism. Arch Neurol. 1971 Dec;25(6):494–500. doi: 10.1001/archneur.1971.00490060028003. [DOI] [PubMed] [Google Scholar]
  18. Muenter M. D., Whisnant J. P. Basal ganglia calcification, hypoparathyroidism, and extrapyramidal motor manifestations. Neurology. 1968 Nov;18(11):1075–1083. doi: 10.1212/wnl.18.11.1075. [DOI] [PubMed] [Google Scholar]
  19. OTA Y., MIYOSHI S., UEDA O., MUKAI T., MAEDA A. Familial paralysis agitans juvenilis; a clinical, anatomical and genetic study. Folia Psychiatr Neurol Jpn. 1958 Jul;12(2):112–121. doi: 10.1111/j.1440-1819.1958.tb00623.x. [DOI] [PubMed] [Google Scholar]
  20. SCHEINBERG I. H., GITLIN D. Deficiency of ceruloplasmin in patients with hepatolenticular degeneration (Wilson's disease). Science. 1952 Oct 31;116(3018):484–485. doi: 10.1126/science.116.3018.484. [DOI] [PubMed] [Google Scholar]
  21. SHY G. M., DRAGER G. A. A neurological syndrome associated with orthostatic hypotension: a clinical-pathologic study. Arch Neurol. 1960 May;2:511–527. doi: 10.1001/archneur.1960.03840110025004. [DOI] [PubMed] [Google Scholar]
  22. Sachs C., Sjöberg H. E., Ericson K. Basal ganglia calcifications on CT: relation to hypoparathyroidism. Neurology. 1982 Jul;32(7):779–782. doi: 10.1212/wnl.32.7.779. [DOI] [PubMed] [Google Scholar]
  23. Steele J. C. Progressive supranuclear palsy. Brain. 1972;95(4):693–704. [PubMed] [Google Scholar]
  24. UZMAN L. L., JAKUS M. A. The Kayser-Fleischer ring; a histochemical and electron microscope study. Neurology. 1957 May;7(5):341–355. doi: 10.1212/wnl.7.5.341. [DOI] [PubMed] [Google Scholar]
  25. Yokochi M., Narabayashi H., Iizuka R., Nagatsu T. Juvenile parkinsonism--some clinical, pharmacological, and neuropathological aspects. Adv Neurol. 1984;40:407–413. [PubMed] [Google Scholar]

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