Figure 3. Effects of aging and exercise on functional hemodynamic response.

Optical intrinsic signal time courses in the whisker barrel cortex of individual old mice in aged sedentary (blue; n = 9) and aged exercise (red; n = 8) mice (a), and young (7 months old) sedentary mice (n = 8) (b). Thick curves represent averages. (c) Average changes in the peak intensity in aged sedentary, aged exercise, and young groups. One-way analysis of variance (ANOVA) with Tukey post hoc test. **p < 0.01; ***p < 0.001; ****p < 0.0001. Please see Supplementary document for exclusions.

Figure 3—figure supplement 1. Differences in the latency (time to peak) of stimulus-induced hemodynamic response between aged sedentary, aged exercise, and young sedentary mice.

Statistical comparisons were carried out using one-way analysis of variance (ANOVA) with Tukey post hoc test.