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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1989 Jun;52(6):736–741. doi: 10.1136/jnnp.52.6.736

Temporal lobe structure as determined by nuclear magnetic resonance in schizophrenia and bipolar affective disorder.

E C Johnstone 1, D G Owens 1, T J Crow 1, C D Frith 1, K Alexandropolis 1, G Bydder 1, N Colter 1
PMCID: PMC1032025  PMID: 2746266

Abstract

Temporal lobe structure has been assessed by magnetic resonance imaging in groups of patients with schizophrenia (n = 21) bipolar affective disorder (n = 20) and normal controls (n = 21). In the temporal lobe area a significant (p less than 0.05) diagnosis by side interaction was present, the area being less on the left than on the right side in patients with schizophrenia in contrast to findings in the two other groups. Lateral ventricular and temporal horn area did not distinguish the groups as a whole. However, there was a significant (p less than 0.05) relationship between lateral ventricular area and poor outcome, and in an analysis confined to males, patients with schizophrenia (n = 15) were found to have significantly (p less than 0.05) enlarged temporal horns.

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Selected References

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  1. Annett M. The growth of manual preference and speed. Br J Psychol. 1970 Nov;61(4):545–558. doi: 10.1111/j.2044-8295.1970.tb01274.x. [DOI] [PubMed] [Google Scholar]
  2. Brown R., Colter N., Corsellis J. A., Crow T. J., Frith C. D., Jagoe R., Johnstone E. C., Marsh L. Postmortem evidence of structural brain changes in schizophrenia. Differences in brain weight, temporal horn area, and parahippocampal gyrus compared with affective disorder. Arch Gen Psychiatry. 1986 Jan;43(1):36–42. doi: 10.1001/archpsyc.1986.01800010038005. [DOI] [PubMed] [Google Scholar]
  3. Ferrier I. N., Roberts G. W., Crow T. J., Johnstone E. C., Owens D. G., Lee Y. C., O'Shaughnessy D., Adrian T. E., Polak J. M., Bloom S. R. Reduced cholecystokinin-like and somatostatin-like immunoreactivity in limbic lobe is associated with negative symptoms in schizophrenia. Life Sci. 1983 Aug 1;33(5):475–482. doi: 10.1016/0024-3205(83)90797-x. [DOI] [PubMed] [Google Scholar]
  4. Flor-Henry P. Psychosis and temporal lobe epilepsy. A controlled investigation. Epilepsia. 1969 Sep;10(3):363–395. doi: 10.1111/j.1528-1157.1969.tb03853.x. [DOI] [PubMed] [Google Scholar]
  5. Johnstone E. C., Crow T. J., Frith C. D., Husband J., Kreel L. Cerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet. 1976 Oct 30;2(7992):924–926. doi: 10.1016/s0140-6736(76)90890-4. [DOI] [PubMed] [Google Scholar]
  6. Johnstone E. C., Frith C. D., Gold A., Stevens M. The outcome of severe acute schizophrenic illnesses after one year. Br J Psychiatry. 1979 Jan;134:28–33. doi: 10.1192/bjp.134.1.28. [DOI] [PubMed] [Google Scholar]
  7. Johnstone E. C., Owens D. G., Gold A., Crow T. J., Macmillan J. F. Schizophrenic patients discharged from hospital--a follow-up study. Br J Psychiatry. 1984 Dec;145:586–590. doi: 10.1192/bjp.145.6.586. [DOI] [PubMed] [Google Scholar]
  8. Lindsay J., Ounsted C., Richards P. Long-term outcome in children with temporal lobe seizures. III: Psychiatric aspects in childhood and adult life. Dev Med Child Neurol. 1979 Oct;21(5):630–636. doi: 10.1111/j.1469-8749.1979.tb01677.x. [DOI] [PubMed] [Google Scholar]
  9. Nelson H. E., O'Connell A. Dementia: the estimation of premorbid intelligence levels using the New Adult Reading Test. Cortex. 1978 Jun;14(2):234–244. doi: 10.1016/s0010-9452(78)80049-5. [DOI] [PubMed] [Google Scholar]
  10. Owens D. G., Johnstone E. C., Crow T. J., Frith C. D., Jagoe J. R., Kreel L. Lateral ventricular size in schizophrenia: relationship to the disease process and its clinical manifestations. Psychol Med. 1985 Feb;15(1):27–41. doi: 10.1017/s0033291700020900. [DOI] [PubMed] [Google Scholar]
  11. Roberts G. W., Ferrier I. N., Lee Y., Crow T. J., Johnstone E. C., Owens D. G., Bacarese-Hamilton A. J., McGregor G., O'Shaughnessey D., Polak J. M. Peptides, the limbic lobe and schizophrenia. Brain Res. 1983 Dec 12;288(1-2):199–211. doi: 10.1016/0006-8993(83)90095-1. [DOI] [PubMed] [Google Scholar]
  12. SLATER E., BEARD A. W., GLITHERO E. The schizophrenialike psychoses of epilepsy. Br J Psychiatry. 1963 Jan;109:95–150. doi: 10.1192/bjp.109.458.95. [DOI] [PubMed] [Google Scholar]
  13. Watt D. C., Katz K., Shepherd M. The natural history of schizophrenia: a 5-year prospective follow-up of a representative sample of schizophrenics by means of a standardized clinical and social assessment. Psychol Med. 1983 Aug;13(3):663–670. doi: 10.1017/s0033291700048091. [DOI] [PubMed] [Google Scholar]
  14. Weinberger D. R., Wagner R. L., Wyatt R. J. Neuropathological studies of schizophrenia: a selective review. Schizophr Bull. 1983;9(2):193–212. doi: 10.1093/schbul/9.2.193. [DOI] [PubMed] [Google Scholar]

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