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. 1987 Jul;50(7):919–922. doi: 10.1136/jnnp.50.7.919

Indices of free radical activity in the cerebrospinal fluid in motor neuron disease.

J D Mitchell, M J Jackson, B Pentland
PMCID: PMC1032134  PMID: 3625217

Abstract

Indices of free-radical activity and lipid peroxidation were studied in cerebrospinal fluid samples obtained from 11 patients with motor neuron disease and 11 reference subjects. No differences were found between the two groups. The significance of this finding is discussed in relation to current views of the possible pathogenesis of this disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bradley W. G., Krasin F. A new hypothesis of the etiology of amyotrophic lateral sclerosis. The DNA hypothesis. Arch Neurol. 1982 Nov;39(11):677–680. doi: 10.1001/archneur.1982.00510230003001. [DOI] [PubMed] [Google Scholar]
  2. Davidson T. J., Hartmann H. A. RNA content and volume of motor neurons in amyotrophic lateral sclerosis. II. The lumbar intumescence and nucleus dorsalis. J Neuropathol Exp Neurol. 1981 Mar;40(2):187–192. doi: 10.1097/00005072-198103000-00009. [DOI] [PubMed] [Google Scholar]
  3. Del Maestro R. F. An approach to free radicals in medicine and biology. Acta Physiol Scand Suppl. 1980;492:153–168. [PubMed] [Google Scholar]
  4. Fletcher B. L., Dillard C. J., Tappel A. L. Measurement of fluorescent lipid peroxidation products in biological systems and tissues. Anal Biochem. 1973 Mar;52(1):1–9. doi: 10.1016/0003-2697(73)90327-8. [DOI] [PubMed] [Google Scholar]
  5. Gutteridge J. M., Rowley D. A., Halliwell B., Westermarck T. Increased non-protein-bound iron and decreased protection against superoxide-radical damage in cerebrospinal fluid from patients with neuronal ceroid lipofuscinoses. Lancet. 1982 Aug 28;2(8296):459–460. doi: 10.1016/s0140-6736(82)90492-5. [DOI] [PubMed] [Google Scholar]
  6. Halliwell B., Gutteridge J. M. The importance of free radicals and catalytic metal ions in human diseases. Mol Aspects Med. 1985;8(2):89–193. doi: 10.1016/0098-2997(85)90001-9. [DOI] [PubMed] [Google Scholar]
  7. Kay L. A. Cellular basis of immune response to antigens of ABO blood-group system. Capacity to provide help during response to T-cell-dependent ABO-system antigens is restricted to individuals of blood group O. Lancet. 1984 Dec 15;2(8416):1369–1371. doi: 10.1016/s0140-6736(84)92061-0. [DOI] [PubMed] [Google Scholar]
  8. McComas A. J., Upton A. R., Sica R. E. Motoneurone disease and ageing. Lancet. 1973 Dec 29;2(7844):1477–1480. doi: 10.1016/s0140-6736(73)92735-9. [DOI] [PubMed] [Google Scholar]
  9. Mitchell J. D., East B. W., Harris I. A., Prescott R. J., Pentland B. Trace elements in the spinal cord and other tissues in motor neuron disease. J Neurol Neurosurg Psychiatry. 1986 Feb;49(2):211–215. doi: 10.1136/jnnp.49.2.211. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Miyata S., Nakamura S., Nagata H., Kameyama M. Increased manganese level in spinal cords of amyotrophic lateral sclerosis determined by radiochemical neutron activation analysis. J Neurol Sci. 1983 Oct;61(2):283–293. doi: 10.1016/0022-510x(83)90012-6. [DOI] [PubMed] [Google Scholar]
  11. Recknagel R. O., Ghoshal A. K. Quantitative estimation of peroxidative degeneration of rat liver microsomal and mitochondrial lipids after carbon tetrachloride poisoning. Exp Mol Pathol. 1966 Oct;5(5):413–426. doi: 10.1016/0014-4800(66)90023-2. [DOI] [PubMed] [Google Scholar]
  12. Santavuori P., Westermarck T. Antioxidant therapy in neuronal ceroid-lipofuscinosis. Med Biol. 1984;62(2):152–153. [PubMed] [Google Scholar]
  13. Vijayalaxmi, Pentland B., Newton M. S., Mitchell J. D., Evans H. J. Spontaneous and mutagen-induced sister chromatid exchange in motor neurone disease. Mutat Res. 1985 Jun-Jul;150(1-2):355–358. doi: 10.1016/0027-5107(85)90132-0. [DOI] [PubMed] [Google Scholar]
  14. Wickens D. G., Graff T. L., Lunec J., Dormandy T. L. Free-radical mediated aggregation of human gamma-globulin. Agents Actions. 1981 Dec;11(6-7):650–651. doi: 10.1007/BF01978780. [DOI] [PubMed] [Google Scholar]
  15. Wickens D. G., Norden A. G., Lunec J., Dormandy T. L. Fluorescence changes in human gamma-globulin induced by free-radical activity. Biochim Biophys Acta. 1983 Feb 15;742(3):607–616. doi: 10.1016/0167-4838(83)90279-0. [DOI] [PubMed] [Google Scholar]

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