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. 1989 May;52(5):578–582. doi: 10.1136/jnnp.52.5.578

Antiviral IgM and IgG subclasses in varicella zoster associated neurological syndromes.

T Mathiesen 1, A Linde 1, E Olding-Stenkvist 1, B Wahren 1
PMCID: PMC1032163  PMID: 2543794

Abstract

The varicella zoster virus (VZV) and herpes simplex virus (HSV) IgGl-4 subclasses were compared in serum and cerebrospinal fluid (CSF) of 22 patients with VZV-associated neurological symptoms, 12 patients with HSV-associated neurological symptoms and 14 controls. The clinical syndromes of the VZV-associated diseases comprised meningo-encephalitis, myelitis, myelopathies and polyneuropathies, mostly with a favourable outcome. A characteristic finding was an intrathecal synthesis of VZV IgG1 and HSV-3. Commonly also IgG2 and 4 were seen in CSF of VZV patients. Their intrathecally synthesised HSV IgG was restricted to IgG1. VZV IgG3 occurred in serum and/or CFS together with VZV IgM in 14 cases and may be a marker of recent VZV replication. In patients with HSV-associated neurological disease, a multi-IgG subclass HSV response and concomitant VZV antibodies restricted to IgG1 was found. Intrathecal synthesis of both HSV and VZV IgG occurred in 20 patients. Detection of two or more VZV or HSV specific IgG subclasses synthesised intrathecally identified the aetiological agent in 19 of these 20 cases.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. APPELBAUM E., KREPS S. I., SUNSHINE A. Herpes zoster encephalitis. Am J Med. 1962 Jan;32:25–31. doi: 10.1016/0002-9343(62)90179-1. [DOI] [PubMed] [Google Scholar]
  2. Felgenhauer K., Ackermann R. Early diagnosis and treatment of herpes simplex encephalitis. J Neurol. 1985;232(2):123–124. doi: 10.1007/BF00313915. [DOI] [PubMed] [Google Scholar]
  3. GIBBS F. A., GIBBS E. L., CARPENTER P. R., SPIES H. W. Electroencephalographic abnormality in "uncomplicated" childhood diseases. J Am Med Assoc. 1959 Oct 24;171:1050–1055. doi: 10.1001/jama.1959.03010260006002. [DOI] [PubMed] [Google Scholar]
  4. Johnson R., Milbourn P. E. Central nervous system manifestations of chickenpox. Can Med Assoc J. 1970 Apr 25;102(8):831–834. [PMC free article] [PubMed] [Google Scholar]
  5. Linnemann C. C., Jr, Alvira M. M. Pathogenesis of varicella-zoster angiitis in the CNS. Arch Neurol. 1980 Apr;37(4):239–240. doi: 10.1001/archneur.1980.00500530077013. [DOI] [PubMed] [Google Scholar]
  6. Mathiesen T., Fridell E., Fredrikson S., Linde A., Sundqvist V. A., Edler D., Wahren B. Combination ELISAs for antiviral antibodies in CSF and serum in patients with neurological symptoms and in healthy controls. J Virol Methods. 1988 Feb;19(2):169–179. doi: 10.1016/0166-0934(88)90160-7. [DOI] [PubMed] [Google Scholar]
  7. Mathiesen T., Linde A., Olding-Stenkvist E., Wahren B. Specific IgG subclass reactivity in herpes simplex encephalitis. J Neurol. 1988 Sep;235(7):400–406. doi: 10.1007/BF00314481. [DOI] [PubMed] [Google Scholar]
  8. Norrby E. Viral antibodies in multiple sclerosis. Prog Med Virol. 1978;24:1–39. [PubMed] [Google Scholar]
  9. Pratesi R., Freemon F. R., Lowry J. L. Herpes zoster ophthalmicus with contralateral hemiplegia. Arch Neurol. 1977 Oct;34(10):640–641. doi: 10.1001/archneur.1977.00500220074015. [DOI] [PubMed] [Google Scholar]
  10. ROSE F. C., BRETT E. M., BURSTON J. ZOSTER ENCEPHALOMYELITIS. Arch Neurol. 1964 Aug;11:155–172. doi: 10.1001/archneur.1964.00460200051005. [DOI] [PubMed] [Google Scholar]
  11. Salmi A., Reunanen M., Ilonen J., Panelius M. Intrathecal antibody synthesis to virus antigens in multiple sclerosis. Clin Exp Immunol. 1983 May;52(2):241–249. [PMC free article] [PubMed] [Google Scholar]
  12. Schmidt N. J. Further evidence for common antigens in herpes simplex and varicella-zoster viruses. J Med Virol. 1982;9(1):27–36. doi: 10.1002/jmv.1890090105. [DOI] [PubMed] [Google Scholar]
  13. Sundqvist V. A., Linde A., Wahren B. Virus-specific immunoglobulin G subclasses in herpes simplex and varicella-zoster virus infections. J Clin Microbiol. 1984 Jul;20(1):94–98. doi: 10.1128/jcm.20.1.94-98.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Vandvik B., Nilsen R. E., Vartdal F., Norrby E. Mumps meningitis: specific and non-specific antibody responses in the central nervous system. Acta Neurol Scand. 1982 May;65(5):468–487. doi: 10.1111/j.1600-0404.1982.tb03104.x. [DOI] [PubMed] [Google Scholar]
  15. Vartdal F., Vandvik B. Multiple sclerosis: subclasses of intrathecally synthesized IgG and measles and varicella zoster virus IgG antibodies. Clin Exp Immunol. 1983 Dec;54(3):641–647. [PMC free article] [PubMed] [Google Scholar]

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