Skip to main content
NCBI home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1989 May;52(5):671–674. doi: 10.1136/jnnp.52.5.671

Magnetic resonance imaging in Leber's optic neuropathy.

A G Kermode 1, I F Moseley 1, B E Kendall 1, D H Miller 1, D G MacManus 1, W I McDonald 1
PMCID: PMC1032188  PMID: 2732742

Abstract

Thirteen males with Leber's optic neuropathy had magnetic resonance imaging (MRI) of the brain, and in eight the optic nerves were imaged using STIR (Short Time Inversion Recovery) sequences. All optic nerve scans were abnormal. In seven with bilateral visual loss four showed bilateral increased optic nerve signal and three unilateral increase. The involvement was of the mid and posterior intra-orbital sections over three 5 mm slices or more with sparing of the anterior portion. One patient with unilateral visual loss had increased signal only on the affected side. Brain MRI was normal, in marked contrast to the findings in clinically isolated optic neuritis in which multiple white matter lesions are seen in the majority.

Full text

PDF
671

Images in this article

672Image
on p.672
672Image
on p.672
673Image
on p.673

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adams J. H., Blackwood W., Wilson J. Further clinical and pathological observations on Leber's optic atrophy. Brain. 1966 Mar;89(1):15–26. doi: 10.1093/brain/89.1.15. [DOI] [PubMed] [Google Scholar]
  2. Barnes D., McDonald W. I., Johnson G., Tofts P. S., Landon D. N. Quantitative nuclear magnetic resonance imaging: characterisation of experimental cerebral oedema. J Neurol Neurosurg Psychiatry. 1987 Feb;50(2):125–133. doi: 10.1136/jnnp.50.2.125. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Barnes D., McDonald W. I., Landon D. N., Johnson G. The characterization of experimental gliosis by quantitative nuclear magnetic resonance imaging. Brain. 1988 Feb;111(Pt 1):83–94. doi: 10.1093/brain/111.1.83. [DOI] [PubMed] [Google Scholar]
  4. Carroll W. M., Mastaglia F. L. Leber's optic neuropathy: a clinical and visual evoked potential study of affected and asymptomatic members of a six generation family. Brain. 1979 Sep;102(3):559–580. doi: 10.1093/brain/102.3.559. [DOI] [PubMed] [Google Scholar]
  5. Holt I. J., Miller D. H., Harding A. E. Restriction endonuclease analysis of leukocyte mitochondrial DNA in Leber's optic atrophy. J Neurol Neurosurg Psychiatry. 1988 Aug;51(8):1075–1077. doi: 10.1136/jnnp.51.8.1075. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Jacobs L., Kinkel P. R., Kinkel W. R. Silent brain lesions in patients with isolated idiopathic optic neuritis. A clinical and nuclear magnetic resonance imaging study. Arch Neurol. 1986 May;43(5):452–455. doi: 10.1001/archneur.1986.00520050032017. [DOI] [PubMed] [Google Scholar]
  7. Johnson G., Miller D. H., MacManus D., Tofts P. S., Barnes D., du Boulay E. P., McDonald W. I. STIR sequences in NMR imaging of the optic nerve. Neuroradiology. 1987;29(3):238–245. doi: 10.1007/BF00451760. [DOI] [PubMed] [Google Scholar]
  8. Miller D. H., Newton M. R., van der Poel J. C., du Boulay E. P., Halliday A. M., Kendall B. E., Johnson G., MacManus D. G., Moseley I. F., McDonald W. I. Magnetic resonance imaging of the optic nerve in optic neuritis. Neurology. 1988 Feb;38(2):175–179. doi: 10.1212/wnl.38.2.175. [DOI] [PubMed] [Google Scholar]
  9. Miller D. H., Ormerod I. E., McDonald W. I., MacManus D. G., Kendall B. E., Kingsley D. P., Moseley I. F. The early risk of multiple sclerosis after optic neuritis. J Neurol Neurosurg Psychiatry. 1988 Dec;51(12):1569–1571. doi: 10.1136/jnnp.51.12.1569. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Nikoskelainen E. K., Savontaus M. L., Wanne O. P., Katila M. J., Nummelin K. U. Leber's hereditary optic neuroretinopathy, a maternally inherited disease. A genealogic study in four pedigrees. Arch Ophthalmol. 1987 May;105(5):665–671. doi: 10.1001/archopht.1987.01060050083043. [DOI] [PubMed] [Google Scholar]
  11. Nikoskelainen E., Hassinen I. E., Paljärvi L., Lang H., Kalimo H. Leber's hereditary optic neuroretinopathy, a mitochondrial disease? Lancet. 1984 Dec 22;2(8417-8418):1474–1474. doi: 10.1016/s0140-6736(84)91669-6. [DOI] [PubMed] [Google Scholar]
  12. Nikoskelainen E., Hoyt W. F., Nummelin K. Ophthalmoscopic findings in Leber's hereditary optic neuropathy. I. Fundus findings in asymptomatic family members. Arch Ophthalmol. 1982 Oct;100(10):1597–1602. doi: 10.1001/archopht.1982.01030040575003. [DOI] [PubMed] [Google Scholar]
  13. Nikoskelainen E., Hoyt W. F., Nummelin K. Ophthalmoscopic findings in Leber's hereditary optic neuropathy. II. The fundus findings in the affected family members. Arch Ophthalmol. 1983 Jul;101(7):1059–1068. doi: 10.1001/archopht.1983.01040020061011. [DOI] [PubMed] [Google Scholar]
  14. Nikoskelainen E. The clinical findings in Leber's hereditary optic neuroretinopathy. Leber's disease. Trans Ophthalmol Soc U K. 1985;104(Pt 8):845–852. [PubMed] [Google Scholar]
  15. Ormerod I. E., McDonald W. I., du Boulay G. H., Kendall B. E., Moseley I. F., Halliday A. M., Kakigi R., Kriss A., Peringer E. Disseminated lesions at presentation in patients with optic neuritis. J Neurol Neurosurg Psychiatry. 1986 Feb;49(2):124–127. doi: 10.1136/jnnp.49.2.124. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Ormerod I. E., Miller D. H., McDonald W. I., du Boulay E. P., Rudge P., Kendall B. E., Moseley I. F., Johnson G., Tofts P. S., Halliday A. M. The role of NMR imaging in the assessment of multiple sclerosis and isolated neurological lesions. A quantitative study. Brain. 1987 Dec;110(Pt 6):1579–1616. doi: 10.1093/brain/110.6.1579. [DOI] [PubMed] [Google Scholar]
  17. WILSON J. Leber's hereditary optic atrophy: some clinical and aetiological considerations. Brain. 1963 Jun;86:347–362. doi: 10.1093/brain/86.2.347. [DOI] [PubMed] [Google Scholar]
  18. Wallace D. C. A new manifestation of Leber's disease and a new explanation for the agency responsible for its unusual pattern of inheritance. Brain. 1970;93(1):121–132. doi: 10.1093/brain/93.1.121. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES