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. 1987 Sep;50(9):1173–1177. doi: 10.1136/jnnp.50.9.1173

Malignant angioendotheliosis involving the nervous system: support for a lymphoid origin of the neoplastic cells.

S E Daniel 1, P Rudge 1, F Scaravilli 1
PMCID: PMC1032351  PMID: 2959757

Abstract

The clinical and post mortem findings of a case of malignant angioendotheliosis are described. The patient presented with neurological signs attributable to repeated episodes of cerebral and spinal cord infarction. Histological examination showed multifocal intravascular proliferation of mononuclear cells. Immunocytochemical characterisation of these neoplastic cells supports the recent suggestion that this disease represents an unusual form of intravascular lymphoma, which appears to show a predilection for blood vessels of the nervous system.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ansbacher L., Low N., Beck D., Boarini D., Jacoby C., Cancilla P. A. Neoplastic angioendotheliosis: a clinicopathological entity with multifocal presentation. Case report. J Neurosurg. 1981 Mar;54(3):412–415. doi: 10.3171/jns.1981.54.3.0412. [DOI] [PubMed] [Google Scholar]
  2. Ansell J., Bhawan J., Cohen S., Sullivan J., Sherman D. Histiocytic lymphoma and malignant angioendotheliomatosis: one disease or two? Cancer. 1982 Oct 15;50(8):1506–1512. doi: 10.1002/1097-0142(19821015)50:8<1506::aid-cncr2820500810>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
  3. Beal M. F., Fisher C. M. Neoplastic angioendotheliosis. J Neurol Sci. 1982 Feb;53(2):359–375. doi: 10.1016/0022-510x(82)90019-3. [DOI] [PubMed] [Google Scholar]
  4. Bhawan J., Wolff S. M., Ucci A. A., Bhan A. K. Malignant lymphoma and malignant angioendotheliomatosis: one disease. Cancer. 1985 Feb 1;55(3):570–576. doi: 10.1002/1097-0142(19850201)55:3<570::aid-cncr2820550316>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
  5. Carroll T. J., Jr, Schelper R. L., Goeken J. A., Kemp J. D. Neoplastic angioendotheliomatosis: immunopathologic and morphologic evidence for intravascular malignant lymphomatosis. Am J Clin Pathol. 1986 Feb;85(2):169–175. doi: 10.1093/ajcp/85.2.169. [DOI] [PubMed] [Google Scholar]
  6. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 39-1986. A 66-year-old woman with fever, fluctuating neurologic signs, and negative blood cultures. N Engl J Med. 1986 Oct 2;315(14):874–885. doi: 10.1056/NEJM198610023151407. [DOI] [PubMed] [Google Scholar]
  7. Choi K. N., Withers H. R., Rotman M. Intracranial metastases from melanoma. Clinical features and treatment by accelerated fractionation. Cancer. 1985 Jul 1;56(1):1–9. doi: 10.1002/1097-0142(19850701)56:1<1::aid-cncr2820560102>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
  8. Dolman C. L., Sweeney V. P., Magil A. Neoplastic angioendotheliosis. The case of the missed primary? Arch Neurol. 1979 Jan;36(1):5–7. doi: 10.1001/archneur.1979.00500370035004. [DOI] [PubMed] [Google Scholar]
  9. Keahey T. M., Guerry D., 4th, Tuthill R. J., Bondi E. E. Malignant angioendotheliomatosis proliferans treated with doxorubicin. Arch Dermatol. 1982 Jul;118(7):512–514. [PubMed] [Google Scholar]
  10. Mori S., Itoyama S., Mohri N., Shibuya A., Hirose T., Takanashi R., Oshimi K., Mizoguchi H., Epstein A. E. Cellular characteristics of neoplastic angioendotheliosis. An immunohistological marker study of 6 cases. Virchows Arch A Pathol Anat Histopathol. 1985;407(2):167–175. doi: 10.1007/BF00737074. [DOI] [PubMed] [Google Scholar]
  11. Ojeda V. J. Neoplastic angioendotheliosis of the spinal cord. Case report. Acta Neuropathol. 1983;62(1-2):164–166. doi: 10.1007/BF00684937. [DOI] [PubMed] [Google Scholar]
  12. Petito C. K., Gottlieb G. J., Dougherty J. H., Petito F. A. Neoplastic angioendotheliosis: ultrastructural study and review of the literature. Ann Neurol. 1978 May;3(5):393–399. doi: 10.1002/ana.410030505. [DOI] [PubMed] [Google Scholar]
  13. Reinglass J. L., Muller J., Wissman S., Wellman H. Central nervous system angioendothelosis. A treatable multiple infarct dementia. Stroke. 1977 Mar-Apr;8(2):218–221. doi: 10.1161/01.str.8.2.218. [DOI] [PubMed] [Google Scholar]
  14. Scott P. W., Silvers D. N., Helwig E. B. Proliferating angioendotheliomatosis. Arch Pathol. 1975 Jun;99(6):323–326. [PubMed] [Google Scholar]
  15. Sheibani K., Battifora H., Winberg C. D., Burke J. S., Ben-Ezra J., Ellinger G. M., Quigley N. J., Fernandez B. B., Morrow D., Rappaport H. Further evidence that "malignant angioendotheliomatosis" is an angiotropic large-cell lymphoma. N Engl J Med. 1986 Apr 10;314(15):943–948. doi: 10.1056/NEJM198604103141502. [DOI] [PubMed] [Google Scholar]
  16. Shiozaki H., Hoshino S., Oshimi K., Mizoguchi H., Tsuzuki C., Hidano A., Mori S. [A case report of neoplastic angioendotheliosis which responded to a combination chemotherapy (CHOP)]. Nihon Naika Gakkai Zasshi. 1984 Mar;73(3):374–378. [PubMed] [Google Scholar]
  17. Warnke R. A., Gatter K. C., Falini B., Hildreth P., Woolston R. E., Pulford K., Cordell J. L., Cohen B., De Wolf-Peeters C., Mason D. Y. Diagnosis of human lymphoma with monoclonal antileukocyte antibodies. N Engl J Med. 1983 Nov 24;309(21):1275–1281. doi: 10.1056/NEJM198311243092102. [DOI] [PubMed] [Google Scholar]
  18. Wick M. R., Banks P. M., McDonald T. J. Angioendotheliomatosis of the nose with fatal systemic dissemination. Cancer. 1981 Dec 1;48(11):2510–2517. doi: 10.1002/1097-0142(19811201)48:11<2510::aid-cncr2820481128>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  19. Wrotnowski U., Mills S. E., Cooper P. H. Malignant angioendotheliomatosis. An angiotropic lymphoma? Am J Clin Pathol. 1985 Feb;83(2):244–248. doi: 10.1093/ajcp/83.2.244. [DOI] [PubMed] [Google Scholar]

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