Skip to main content
NCBI home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1987 Oct;50(10):1306–1311. doi: 10.1136/jnnp.50.10.1306

Correlations between cerebral blood flow variations and clinical parameters in temporal lobe epilepsy: an interictal study.

J Valmier 1, J Touchon 1, P Daures 1, M Zanca 1, M Baldy-Moulinier 1
PMCID: PMC1032456  PMID: 3681308

Abstract

Regional cerebral blood flow (rCBF) measurements were determined by the intravenous Xenon 133 technique in 80 patients suffering from temporal lobe epilepsy. All the patients had a normal CT scan. Three subgroups were differentiated, according to EEG and all-night polygraphic recordings: temporal lobe epilepsy with left (N = 25) or right (N = 25) EEG epileptic abnormalities and temporal lobe epilepsy with EEG abnormalities in both temporal regions with asynchronous occurrence (n = 30). In comparison with a control group (n = 20), there was (1) a marked reduction of blood flow in the temporal region corresponding to the site of the epileptic focus and (2) a reduction in blood flow in distant brain areas and the contralateral hemisphere. The rCBF decrease was highly correlated (p less than 0.001) with the disease severity (taking into account the complex partial seizure frequency and the number of secondary generalised seizures). Differences were found in the rCBF decrease between left and right temporal lobe epilepsy.

Full text

PDF
1306

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baldy-Moulinier M., Valmier J., Touchon J., Billiard M., Besset A., Cadilhac J. Débits cérébraux régionaux diminués en période intercritique dans l'épilepsie du lobe temporal. Rev Neurol (Paris) 1985;141(1):18–27. [PubMed] [Google Scholar]
  2. Bonte F. J., Stokely E. M., Devous M. D., Sr, Homan R. W. Single-proton tomographic study of regional cerebral blood flow in epilepsy. A preliminary report. Arch Neurol. 1983 May;40(5):267–270. doi: 10.1001/archneur.1983.04050050035003. [DOI] [PubMed] [Google Scholar]
  3. Engel J., Jr, Brown W. J., Kuhl D. E., Phelps M. E., Mazziotta J. C., Crandall P. H. Pathological findings underlying focal temporal lobe hypometabolism in partial epilepsy. Ann Neurol. 1982 Dec;12(6):518–528. doi: 10.1002/ana.410120604. [DOI] [PubMed] [Google Scholar]
  4. Engel J., Jr, Kuhl D. E., Phelps M. E., Mazziotta J. C. Interictal cerebral glucose metabolism in partial epilepsy and its relation to EEG changes. Ann Neurol. 1982 Dec;12(6):510–517. doi: 10.1002/ana.410120603. [DOI] [PubMed] [Google Scholar]
  5. Engel J., Jr, Kuhl D. E., Phelps M. E. Patterns of human local cerebral glucose metabolism during epileptic seizures. Science. 1982 Oct 1;218(4567):64–66. doi: 10.1126/science.6981843. [DOI] [PubMed] [Google Scholar]
  6. Gastaut H. Clinical and electroencephalographical classification of epileptic seizures. Epilepsia. 1970 Mar;11(1):102–113. doi: 10.1111/j.1528-1157.1970.tb03871.x. [DOI] [PubMed] [Google Scholar]
  7. Howse D. C., Caronna J. J., Duffy T. E., Plum F. Cerebral energy metabolism, pH, and blood flow during seizures in the cat. Am J Physiol. 1974 Dec;227(6):1444–1451. doi: 10.1152/ajplegacy.1974.227.6.1444. [DOI] [PubMed] [Google Scholar]
  8. KETY S. S. Human cerebral blood flow and oxygen consumption as related to aging. J Chronic Dis. 1956 May;3(5):478–486. doi: 10.1016/0021-9681(56)90146-1. [DOI] [PubMed] [Google Scholar]
  9. Kuhl D. E., Engel J., Jr, Phelps M. E., Selin C. Epileptic patterns of local cerebral metabolism and perfusion in humans determined by emission computed tomography of 18FDG and 13NH3. Ann Neurol. 1980 Oct;8(4):348–360. doi: 10.1002/ana.410080403. [DOI] [PubMed] [Google Scholar]
  10. Lavy S., Melamed E., Portnoy Z., Carmon A. Interictal regional cerebral blood flow in patients with partial seizures. Neurology. 1976 May;26(5):418–422. doi: 10.1212/wnl.26.5.418. [DOI] [PubMed] [Google Scholar]
  11. Lieb J. P., Joseph J. P., Engel J., Jr, Walker J., Crandall P. H. Sleep state and seizure foci related to depth spike activity in patients with temporal lobe epilepsy. Electroencephalogr Clin Neurophysiol. 1980 Sep;49(5-6):538–557. doi: 10.1016/0013-4694(80)90396-x. [DOI] [PubMed] [Google Scholar]
  12. McLachlan R. S., Nicholson R. L., Black S., Carr T., Blume W. T. Nuclear magnetic resonance imaging, a new approach to the investigation of refractory temporal lobe epilepsy. Epilepsia. 1985 Nov-Dec;26(6):555–562. doi: 10.1111/j.1528-1157.1985.tb05691.x. [DOI] [PubMed] [Google Scholar]
  13. Melamed E., Lavy S., Bentin S., Cooper G., Rinot Y. Reduction in regional cerebral blood flow during normal aging in man. Stroke. 1980 Jan-Feb;11(1):31–35. doi: 10.1161/01.str.11.1.31. [DOI] [PubMed] [Google Scholar]
  14. Meric P., Seylaz J., Correze J. L., Luft A., Mamo H. Measurement of regional cerebral blood flow by intravenous injection of Xe133. Med Prog Technol. 1979 Jan 30;6(2):53–63. [PubMed] [Google Scholar]
  15. Naritomi H., Meyer J. S., Sakai F., Yamaguchi F., Shaw T. Effects of advancing age on regional cerebral blood flow. Studies in normal subjects and subjects with risk factors for atherothrombotic stroke. Arch Neurol. 1979 Jul;36(7):410–416. doi: 10.1001/archneur.1979.00500430040005. [DOI] [PubMed] [Google Scholar]
  16. Plum F., Posner J. B., Troy B. Cerebral metabolic and circulatory responses to induced convulsions in animals. Arch Neurol. 1968 Jan;18(1):1–13. doi: 10.1001/archneur.1968.00470310015001. [DOI] [PubMed] [Google Scholar]
  17. Seylaz J., Meric P., Correze J. L., Luft A., Mamo H. Analytical problems associated with the noninvasive measurements of cerebral blood flow in cerebrovascular diseases. Med Biol Eng Comput. 1980 Jan;18(1):39–47. doi: 10.1007/BF02442478. [DOI] [PubMed] [Google Scholar]
  18. Theodore W. H., Newmark M. E., Sato S., Brooks R., Patronas N., De La Paz R., DiChiro G., Kessler R. M., Margolin R., Manning R. G. [18F]fluorodeoxyglucose positron emission tomography in refractory complex partial seizures. Ann Neurol. 1983 Oct;14(4):429–437. doi: 10.1002/ana.410140406. [DOI] [PubMed] [Google Scholar]
  19. Touchon J., Valmier J., Baldy-Moulinier M., Cadilhac J. Regional cerebral blood flow during interictal state: differences between temporal lobe epilepsy and primary generalized epilepsy. Eur Neurol. 1986;25(1):43–52. doi: 10.1159/000115986. [DOI] [PubMed] [Google Scholar]
  20. Valmier J., Touchon J., Baldy-Moulinier M. Etude des débits sanguins cérébraux régionaux dans les épilepsies partielles complexes lésionnelles et non lésionnelles. Rev Electroencephalogr Neurophysiol Clin. 1986 Oct;16(3):229–237. doi: 10.1016/s0370-4475(86)80050-8. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES