Skip to main content
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1987 Dec;50(12):1597–1601. doi: 10.1136/jnnp.50.12.1597

Cerebral blood flow in systemic lupus erythematosus with and without central nervous system involvement.

H H Awada 1, H L Mamo 1, A G Luft 1, J C Ponsin 1, M F Kahn 1
PMCID: PMC1032600  PMID: 3437293

Abstract

Regional cerebral blood flow (rCBF) was studied by the intravenous 133Xe method in 38 patients with systemic lupus erythematosus (SLE); 21 patients had neuropsychiatric manifestations (N+) and 17 did not (N-). Twelve of the N+ patients had had neuropsychiatric episodes less than one year before measurement of CBF ("recent" N+), while seven patients in this group had had episodes over a year before measurement ("old" N+). The results were compared with those obtained from a group of 27 age-matched normal healthy subjects. It was found that, in most of the N+ and N- patients, rCBF was evenly distributed bilaterally, but there was a "patchwork" of high/normal and low flow areas. This disturbance of rCBF distribution was significantly greater in "recent" N+ patients than in "old" N- patients, but was not a function of the potential evolution of systemic lupus erythematosus. It was also found that there was a reduction in the physiological high frontal rCBF in the "old" N+ patients. No correlation could be found between rCBF, the topography of the neuropsychological lesions, other neurological investigations or the glucocorticoid dosage and treatment schedules.

Full text

PDF
1597

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blauenstein U. W., Halsey J. H., Jr, Wilson E. M., Wills E. L., Risberg J. 133Xenon inhalation method. Analysis of reproducibility: some of its physiological implications. Stroke. 1977 Jan-Feb;8(1):92–102. doi: 10.1161/01.str.8.1.92. [DOI] [PubMed] [Google Scholar]
  2. Bresnihan B., Hohmeister R., Cutting J., Travers R. L., Waldburger M., Black C., Jones T., Hughes G. R. The neuropsychiatric disorder in systemic lupus erythematosus: evidence for both vascular and immune mechanisms. Ann Rheum Dis. 1979 Aug;38(4):301–306. doi: 10.1136/ard.38.4.301. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Ellis S. G., Verity M. A. Central nervous system involvement in systemic lupus erythematosus: a review of neuropathologic findings in 57 cases, 1955--1977. Semin Arthritis Rheum. 1979 Feb;8(3):212–221. doi: 10.1016/s0049-0172(79)80009-8. [DOI] [PubMed] [Google Scholar]
  4. Hiraiwa M., Nonaka C., Abe T., Iio M. Positron emission tomography in systemic lupus erythematosus: relation of cerebral vasculitis to PET findings. AJNR Am J Neuroradiol. 1983 May-Jun;4(3):541–543. [PMC free article] [PubMed] [Google Scholar]
  5. Ingvar D. H. "Hyperfrontal" distribution of the cerebral grey matter flow in resting wakefulness; on the functional anatomy of the conscious state. Acta Neurol Scand. 1979 Jul;60(1):12–25. doi: 10.1111/j.1600-0404.1979.tb02947.x. [DOI] [PubMed] [Google Scholar]
  6. Johnson R. T., Richardson E. P. The neurological manifestations of systemic lupus erythematosus. Medicine (Baltimore) 1968 Jul;47(4):337–369. doi: 10.1097/00005792-196807000-00002. [DOI] [PubMed] [Google Scholar]
  7. Lassen N. A., Roland P. E., Larsen B., Melamed E., Soh K. Mapping of human cerebral functions: a study of the regional cerebral blood flow pattern during rest, its reproducibility and the activations seen during basic sensory and motor functions. Acta Neurol Scand Suppl. 1977;64:262-3, 274-5. [PubMed] [Google Scholar]
  8. Mamo H., Meric P., Luft A., Seylaz J. Hyperfrontal pattern of human cerebral circulation. Variations with age and atherosclerotic state. Arch Neurol. 1983 Oct;40(10):626–632. doi: 10.1001/archneur.1983.04050090062010. [DOI] [PubMed] [Google Scholar]
  9. Melamed E., Lavy S., Bentin S., Cooper G., Rinot Y. Reduction in regional cerebral blood flow during normal aging in man. Stroke. 1980 Jan-Feb;11(1):31–35. doi: 10.1161/01.str.11.1.31. [DOI] [PubMed] [Google Scholar]
  10. Meric P., Luft A., Seylaz J., Mamo H. Analysis of reproducibility and sensitivity of atraumatic measurements of regional cerebral blood flow in cerebrovascular diseases. Stroke. 1983 Jan-Feb;14(1):82–87. doi: 10.1161/01.str.14.1.82. [DOI] [PubMed] [Google Scholar]
  11. Meric P., Seylaz J., Correze J. L., Luft A., Mamo H. Measurement of regional cerebral blood flow by intravenous injection of Xe133. Med Prog Technol. 1979 Jan 30;6(2):53–63. [PubMed] [Google Scholar]
  12. Méric P., Seylaz J., Luft A., Corrèze J. L., Mamo H. Measurement of regional cerebral blood flow by intravenous injection of 133Xe. Acta Neurol Scand Suppl. 1977;64:462–463. [PubMed] [Google Scholar]
  13. Obrist W. D., Thompson H. K., Jr, King C. H., Wang H. S. Determination of regional cerebral blood flow by inhalation of 133-Xenon. Circ Res. 1967 Jan;20(1):124–135. doi: 10.1161/01.res.20.1.124. [DOI] [PubMed] [Google Scholar]
  14. Pinching A. J., Travers R. L., Hughes G. R., Jones T., Moss S. Oxygen-15 brain scanning for detection of cerebral involvement in systemic lupus erythematosus. Lancet. 1978 Apr 29;1(8070):898–900. doi: 10.1016/s0140-6736(78)90680-3. [DOI] [PubMed] [Google Scholar]
  15. Seylaz J., Meric P., Correze J. L., Luft A., Mamo H. Analytical problems associated with the noninvasive measurements of cerebral blood flow in cerebrovascular diseases. Med Biol Eng Comput. 1980 Jan;18(1):39–47. doi: 10.1007/BF02442478. [DOI] [PubMed] [Google Scholar]
  16. Tan E. M., Cohen A. S., Fries J. F., Masi A. T., McShane D. J., Rothfield N. F., Schaller J. G., Talal N., Winchester R. J. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982 Nov;25(11):1271–1277. doi: 10.1002/art.1780251101. [DOI] [PubMed] [Google Scholar]
  17. Wilkinson I. M., Bull J. W., Duboulay G. H., Marshall J., Russell R. W., Symon L. Regional blood flow in the normal cerebral hemisphere. J Neurol Neurosurg Psychiatry. 1969 Oct;32(5):367–378. doi: 10.1136/jnnp.32.5.367. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Wilson E. M., Wills E. L., Risberg J., Halsey J. H., Jr, Gerard J. D., May C. P. Measurement of regional blood flow by the 133xenon inhalation method with an on-line computer. Comput Biol Med. 1977 Apr;7(2):143–157. doi: 10.1016/0010-4825(77)90019-1. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES