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. 1987 Dec;50(12):1625–1632. doi: 10.1136/jnnp.50.12.1625

Susceptibility to pressure neuropathy distal to a constricting ligature in the guinea-pig.

T Shimpo 1, R W Gilliatt 1, R P Kennett 1, P J Allen 1
PMCID: PMC1032604  PMID: 2830368

Abstract

Silk ligatures were tied round the sciatic nerve in guinea-pigs and left in place in order to produce persistent nerve constriction. Serial nerve conduction studies over the following 9 weeks showed a reduction in motor conduction velocity distal to the ligature. The presence of axonal atrophy in tibial nerve fibres in the leg was subsequently confirmed by histological studies. These changes were not seen in a second group of animals in which similar ligatures were tied but removed after 6 hours. When the ligatures were left in place, the animals developed local plantar nerve lesions in the sole of the foot on the affected side, which were thought to be due to pressure from the floor of the cage. Local pressure changes of varying severity were seen in the foot in all the constricted nerves, but were only occasionally found in control nerves from the opposite foot, or in nerves which had been constricted for a few hours by ligatures which were then removed. These results suggest that atrophic nerve fibres distal to a persistent constriction may be particularly sensitive to local pressure.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baba M., Fowler C. J., Jacobs J. M., Gilliatt R. W. Changes in peripheral nerve fibres distal to a constriction. J Neurol Sci. 1982 May;54(2):197–208. doi: 10.1016/0022-510x(82)90182-4. [DOI] [PubMed] [Google Scholar]
  2. Baba M., Gilliatt R. W., Harding A. E., Reiners K. Demyelination following diphtheria toxin in the presence of axonal atrophy. J Neurol Sci. 1984 May;64(2):199–211. doi: 10.1016/0022-510x(84)90038-8. [DOI] [PubMed] [Google Scholar]
  3. Baba M., Gilliatt R. W., Jacobs J. M. Recovery of distal changes after nerve constriction by a ligature. J Neurol Sci. 1983 Aug;60(2):235–246. doi: 10.1016/0022-510x(83)90065-5. [DOI] [PubMed] [Google Scholar]
  4. Dyck P. J., Johnson W. J., Lambert E. H., O'Brien P. C. Segmental demyelination secondary to axonal degeneration in uremic neuropathy. Mayo Clin Proc. 1971 Jun;46(6):400–431. [PubMed] [Google Scholar]
  5. Hoffman P. N., Griffin J. W., Price D. L. Control of axonal caliber by neurofilament transport. J Cell Biol. 1984 Aug;99(2):705–714. doi: 10.1083/jcb.99.2.705. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hopkins A. P., Morgan-Hughes J. A. The effect of local pressure in diphtheritic neuropathy. J Neurol Neurosurg Psychiatry. 1969 Dec;32(6):614–623. doi: 10.1136/jnnp.32.6.614. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Jefferson D., Eames R. A. Subclinical entrapment of the lateral femoral cutaneous nerve: an autopsy study. Muscle Nerve. 1979 Mar-Apr;2(2):145–154. doi: 10.1002/mus.880020209. [DOI] [PubMed] [Google Scholar]
  8. Neary D., Ochoa J., Gilliatt R. W. Sub-clinical entrapment neuropathy in man. J Neurol Sci. 1975 Mar;24(3):283–298. doi: 10.1016/0022-510x(75)90248-8. [DOI] [PubMed] [Google Scholar]
  9. Nukada H., Dyck P. J., Karnes J. L. Thin axons relative to myelin spiral length in hereditary motor and sensory neuropathy, type I. Ann Neurol. 1983 Dec;14(6):648–655. doi: 10.1002/ana.410140608. [DOI] [PubMed] [Google Scholar]
  10. Ochoa J., Marotte L. The nature of the nerve lesion caused by chronic entrapment in the guinea-pig. J Neurol Sci. 1973 Aug;19(4):491–495. doi: 10.1016/0022-510x(73)90045-2. [DOI] [PubMed] [Google Scholar]
  11. Ohi T., Kyle R. A., Dyck P. J. Axonal attenuation and secondary segmental demyelination in myeloma neuropathies. Ann Neurol. 1985 Mar;17(3):255–261. doi: 10.1002/ana.410170306. [DOI] [PubMed] [Google Scholar]
  12. Ortman J. A., Sahenk Z., Mendell J. R. The experimental production of Renaut bodies. J Neurol Sci. 1983 Dec;62(1-3):233–241. doi: 10.1016/0022-510x(83)90202-2. [DOI] [PubMed] [Google Scholar]
  13. Reiners K., Gilliatt R. W., Harding A. E., O'Neill J. H. Regeneration following tibial nerve crush in the rabbit: the effect of proximal constriction. J Neurol Neurosurg Psychiatry. 1987 Jan;50(1):6–11. doi: 10.1136/jnnp.50.1.6. [DOI] [PMC free article] [PubMed] [Google Scholar]

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