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. 1987 Dec;50(12):1641–1646. doi: 10.1136/jnnp.50.12.1641

Somatosensory evoked potentials following stimulation of the lower limb in cortical reflex myoclonus.

R Kakigi 1, H Shibasaki 1
PMCID: PMC1032606  PMID: 3437295

Abstract

Generating mechanisms of giant somatosensory evoked potentials (SEPs) following stimulation of the posterior tibial nerve as well as the big toe were investigated in three patients with cortical reflex myoclonus. Scalp distributions of recognisable components were very similar to those in normal subjects, except that their amplitude was much larger. The tibial nerve SEPs were remarkably attenuated by interfering tactile stimulation. Therefore, the giant SEPs observed in the present cases seem to be, at least partially, due to input from cutaneous nerve fibres on the background of extremely enhanced excitability in area 3b of the primary sensory cortex where normal SEPs are generated.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chadwick D., Hallett M., Harris R., Jenner P., Reynolds E. H., Marsden C. D. Clinical, biochemical, and physiological features distinguishing myoclonus responsive to 5-hydroxytryptophan, tryptophan with a monoamine oxidase inhibitor, and clonazepam. Brain. 1977 Sep;100(3):455–487. doi: 10.1093/brain/100.3.455. [DOI] [PubMed] [Google Scholar]
  2. Cowan J. M., Rothwell J. C., Wise R. J., Marsden C. D. Electrophysiological and positron emission studies in a patient with cortical myoclonus, epilepsia partialis continua and motor epilepsy. J Neurol Neurosurg Psychiatry. 1986 Jul;49(7):796–807. doi: 10.1136/jnnp.49.7.796. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cruse R., Klem G., Lesser R. P., Leuders H. Paradoxical lateralization of cortical potentials evoked by stimulation of posterior tibial nerve. Arch Neurol. 1982 Apr;39(4):222–225. doi: 10.1001/archneur.1982.00510160028005. [DOI] [PubMed] [Google Scholar]
  4. Desmedt J. E., Bourguet M. Color imaging of parietal and frontal somatosensory potential fields evoked by stimulation of median or posterior tibial nerve in man. Electroencephalogr Clin Neurophysiol. 1985 Jan;62(1):1–17. doi: 10.1016/0168-5597(85)90030-9. [DOI] [PubMed] [Google Scholar]
  5. Hallett M., Chadwick D., Marsden C. D. Cortical reflex myoclonus. Neurology. 1979 Aug;29(8):1107–1125. doi: 10.1212/wnl.29.8.1107. [DOI] [PubMed] [Google Scholar]
  6. Halliday A. M., Halliday E. Cortical evoked potentials in patients with benign essential myoclonus and progressive myoclonic epilepsy. Electroencephalogr Clin Neurophysiol. 1970 Jul;29(1):106–107. [PubMed] [Google Scholar]
  7. Halliday A. M. The electrophysiological study of myoclonus in man. Brain. 1967 Jun;90(2):241–284. doi: 10.1093/brain/90.2.241. [DOI] [PubMed] [Google Scholar]
  8. Jones S. J. An 'interference" approach to the study of somatosensory evoked potentials in man. Electroencephalogr Clin Neurophysiol. 1981 Dec;52(6):517–530. doi: 10.1016/0013-4694(81)91427-9. [DOI] [PubMed] [Google Scholar]
  9. Jones S. J., Power C. N. Scalp topography of human somatosensory evoked potentials: the effect of interfering tactile stimulation applied to the hand. Electroencephalogr Clin Neurophysiol. 1984 Jul;58(1):25–36. doi: 10.1016/0013-4694(84)90197-4. [DOI] [PubMed] [Google Scholar]
  10. Kakigi R. Ipsilateral and contralateral SEP components following median nerve stimulation: effects of interfering stimuli applied to the contralateral hand. Electroencephalogr Clin Neurophysiol. 1986 Sep;64(3):246–259. doi: 10.1016/0013-4694(86)90172-0. [DOI] [PubMed] [Google Scholar]
  11. Kakigi R., Jones S. J. Effects on median nerve SEPs of tactile stimulation applied to adjacent and remote areas of the body surface. Electroencephalogr Clin Neurophysiol. 1985 Jul;62(4):252–265. doi: 10.1016/0168-5597(85)90003-6. [DOI] [PubMed] [Google Scholar]
  12. Kakigi R., Shibasaki H., Hashizume A., Kuroiwa Y. Short latency somatosensory evoked spinal and scalp-recorded potentials following posterior tibial nerve stimulation in man. Electroencephalogr Clin Neurophysiol. 1982 Jun;53(6):602–611. doi: 10.1016/0013-4694(82)90136-5. [DOI] [PubMed] [Google Scholar]
  13. Kakigi R., Shibasaki H. Scalp topography of the short latency somatosensory evoked potentials following posterior tibial nerve stimulation in man. Electroencephalogr Clin Neurophysiol. 1983 Nov;56(5):430–437. doi: 10.1016/0013-4694(83)90225-0. [DOI] [PubMed] [Google Scholar]
  14. Kakigi R. The effect of aging on somatosensory evoked potentials following stimulation of the posterior tibial nerve in man. Electroencephalogr Clin Neurophysiol. 1987 Jul;68(4):277–286. doi: 10.1016/0168-5597(87)90048-7. [DOI] [PubMed] [Google Scholar]
  15. Kelly J. J., Jr, Sharbrough F. W., Daube J. R. A clinical and electrophysiological evaluation of myoclonus. Neurology. 1981 May;31(5):581–589. doi: 10.1212/wnl.31.5.581. [DOI] [PubMed] [Google Scholar]
  16. Lovrich D., Simson R., Vaughan H. G., Jr, Ritter W. Topography of visual event-related potentials during geometric and phonetic discriminations. Electroencephalogr Clin Neurophysiol. 1986 Jan;65(1):1–12. doi: 10.1016/0168-5597(86)90031-6. [DOI] [PubMed] [Google Scholar]
  17. Obeso J. A., Rothwell J. C., Marsden C. D. The spectrum of cortical myoclonus. From focal reflex jerks to spontaneous motor epilepsy. Brain. 1985 Mar;108(Pt 1):193–124. doi: 10.1093/brain/108.1.193. [DOI] [PubMed] [Google Scholar]
  18. Paul R. L., Merzenich M., Goodman H. Representation of slowly and rapidly adapting cutaneous mechanoreceptors of the hand in Brodmann's areas 3 and 1 of Macaca mulatta. Brain Res. 1972 Jan 28;36(2):229–249. doi: 10.1016/0006-8993(72)90732-9. [DOI] [PubMed] [Google Scholar]
  19. Rothwell J. C., Obeso J. A., Marsden C. D. On the significance of giant somatosensory evoked potentials in cortical myoclonus. J Neurol Neurosurg Psychiatry. 1984 Jan;47(1):33–42. doi: 10.1136/jnnp.47.1.33. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Seyal M., Emerson R. G., Pedley T. A. Spinal and early scalp-recorded components of the somatosensory evoked potential following stimulation of the posterior tibial nerve. Electroencephalogr Clin Neurophysiol. 1983 Mar;55(3):320–330. doi: 10.1016/0013-4694(83)90210-9. [DOI] [PubMed] [Google Scholar]
  21. Shibasaki H., Kuroiwa Y. Electroencephalographic correlates of myoclonus. Electroencephalogr Clin Neurophysiol. 1975 Nov;39(5):455–463. doi: 10.1016/0013-4694(75)90046-2. [DOI] [PubMed] [Google Scholar]
  22. Shibasaki H., Neshige R., Hashiba Y. Cortical excitability after myoclonus: jerk-locked somatosensory evoked potentials. Neurology. 1985 Jan;35(1):36–41. doi: 10.1212/wnl.35.1.36. [DOI] [PubMed] [Google Scholar]
  23. Shibasaki H., Yamashita Y., Kuroiwa Y. Electroencephalographic studies myoclonus. Brain. 1978 Sep;101(3):447–460. doi: 10.1093/brain/101.3.447. [DOI] [PubMed] [Google Scholar]
  24. Shibasaki H., Yamashita Y., Neshige R., Tobimatsu S., Fukui R. Pathogenesis of giant somatosensory evoked potentials in progressive myoclonic epilepsy. Brain. 1985 Mar;108(Pt 1):225–240. doi: 10.1093/brain/108.1.225. [DOI] [PubMed] [Google Scholar]
  25. Sutton G. G., Mayer R. F. Focal reflex myoclonus. J Neurol Neurosurg Psychiatry. 1974 Feb;37(2):207–217. doi: 10.1136/jnnp.37.2.207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Tobimatsu S., Fukui R., Shibasaki H., Kato M., Kuroiwa Y. Electrophysiological studies of myoclonus in sialidosis type 2. Electroencephalogr Clin Neurophysiol. 1985 Jan;60(1):16–22. doi: 10.1016/0013-4694(85)90944-7. [DOI] [PubMed] [Google Scholar]
  27. WATSON C. W., DENNY-BROWN D. Studies of the mechanism of stimulus-sensitive myoclonus in man. Electroencephalogr Clin Neurophysiol. 1955 Aug;7(3):341–356. doi: 10.1016/0013-4694(55)90002-x. [DOI] [PubMed] [Google Scholar]

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