Fig. 4|. A high-throughput application of SMAD for rapid screening of human cellular multi-omics responses to drugs.

a, Overview of experimental design and sample processing flow in 96-well plates. b, Molecular information and data quality of multi-omics dataset acquired by SMAD. including identified, quantified feature, coefficient of Variances. c, The Heatmap showing significant dysregulated molecules among drug treatments. d, Four clusters of significant metabolites and proteins (K-means clustering). e, UMAP analysis of multi-omics responses among all drugs and controls. (All metabolite features and proteins included). f, Examples of proteins and metabolites for each cluster. g, pathway network for xxx.