Skip to main content
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1988 Dec;51(12):1569–1571. doi: 10.1136/jnnp.51.12.1569

The early risk of multiple sclerosis after optic neuritis.

D H Miller 1, I E Ormerod 1, W I McDonald 1, D G MacManus 1, B E Kendall 1, D P Kingsley 1, I F Moseley 1
PMCID: PMC1032775  PMID: 3221224

Abstract

Serial brain MRI was performed in 53 patients with clinically isolated optic neuritis. Using clinical and imaging evidence for relapse, multiple sclerosis developed within a mean of 12 months in 19 of 34 cases (56%) with brain lesions at presentation, and in only 3 of 19 cases (16%) without (Relative Risk = 6.8, p less than 0.005).

Full text

PDF
1569

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atlas S. W., Grossman R. I., Goldberg H. I., Hackney D. B., Bilaniuk L. T., Zimmerman R. A. MR diagnosis of acute disseminated encephalomyelitis. J Comput Assist Tomogr. 1986 Sep-Oct;10(5):798–801. doi: 10.1097/00004728-198609000-00017. [DOI] [PubMed] [Google Scholar]
  2. Bradley W. G., Whitty C. W. Acute optic neuritis: prognosis for development of multiple sclerosis. J Neurol Neurosurg Psychiatry. 1968 Feb;31(1):10–18. doi: 10.1136/jnnp.31.1.10. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Brant-Zawadzki M., Fein G., Van Dyke C., Kiernan R., Davenport L., de Groot J. MR imaging of the aging brain: patchy white-matter lesions and dementia. AJNR Am J Neuroradiol. 1985 Sep-Oct;6(5):675–682. [PMC free article] [PubMed] [Google Scholar]
  4. Cohen M. M., Lessell S., Wolf P. A. A prospective study of the risk of developing multiple sclerosis in uncomplicated optic neuritis. Neurology. 1979 Feb;29(2):208–213. doi: 10.1212/wnl.29.2.208. [DOI] [PubMed] [Google Scholar]
  5. Collis W. J. Acute unilateral retrobulbar neuritis. Arch Neurol. 1965 Oct;13(4):409–412. doi: 10.1001/archneur.1965.00470040075012. [DOI] [PubMed] [Google Scholar]
  6. Compston D. A., Batchelor J. R., Earl C. J., McDonald W. I. Factors influencing the risk of multiple sclerosis developing in patients with optic neuritis. Brain. 1978 Sep;101(3):495–511. doi: 10.1093/brain/101.3.495. [DOI] [PubMed] [Google Scholar]
  7. Dun V., Bale J. F., Jr, Zimmerman R. A., Perdue Z., Bell W. E. MRI in children with postinfectious disseminated encephalomyelitis. Magn Reson Imaging. 1986;4(1):25–32. doi: 10.1016/0730-725x(86)91086-6. [DOI] [PubMed] [Google Scholar]
  8. Francis D. A., Compston D. A., Batchelor J. R., McDonald W. I. A reassessment of the risk of multiple sclerosis developing in patients with optic neuritis after extended follow-up. J Neurol Neurosurg Psychiatry. 1987 Jun;50(6):758–765. doi: 10.1136/jnnp.50.6.758. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Gerard G., Weisberg L. A. MRI periventricular lesions in adults. Neurology. 1986 Jul;36(7):998–1001. doi: 10.1212/wnl.36.7.998. [DOI] [PubMed] [Google Scholar]
  10. Hutchinson W. M. Acute optic neuritis and the prognosis for multiple sclerosis. J Neurol Neurosurg Psychiatry. 1976 Mar;39(3):283–289. doi: 10.1136/jnnp.39.3.283. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Jacobs L., Kinkel P. R., Kinkel W. R. Silent brain lesions in patients with isolated idiopathic optic neuritis. A clinical and nuclear magnetic resonance imaging study. Arch Neurol. 1986 May;43(5):452–455. doi: 10.1001/archneur.1986.00520050032017. [DOI] [PubMed] [Google Scholar]
  12. Nikoskelainen E., Frey H., Salmi A. Prognosis of optic neuritis with special reference to cerebrospinal fluid immunoglobulins and measles virus antibodies. Ann Neurol. 1981 Jun;9(6):545–550. doi: 10.1002/ana.410090606. [DOI] [PubMed] [Google Scholar]
  13. Ormerod I. E., McDonald W. I., du Boulay G. H., Kendall B. E., Moseley I. F., Halliday A. M., Kakigi R., Kriss A., Peringer E. Disseminated lesions at presentation in patients with optic neuritis. J Neurol Neurosurg Psychiatry. 1986 Feb;49(2):124–127. doi: 10.1136/jnnp.49.2.124. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Ormerod I. E., Miller D. H., McDonald W. I., du Boulay E. P., Rudge P., Kendall B. E., Moseley I. F., Johnson G., Tofts P. S., Halliday A. M. The role of NMR imaging in the assessment of multiple sclerosis and isolated neurological lesions. A quantitative study. Brain. 1987 Dec;110(Pt 6):1579–1616. doi: 10.1093/brain/110.6.1579. [DOI] [PubMed] [Google Scholar]
  15. Poser C. M., Paty D. W., Scheinberg L., McDonald W. I., Davis F. A., Ebers G. C., Johnson K. P., Sibley W. A., Silberberg D. H., Tourtellotte W. W. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol. 1983 Mar;13(3):227–231. doi: 10.1002/ana.410130302. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES