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. Author manuscript; available in PMC: 2023 Oct 12.
Published in final edited form as: Nature. 2023 Apr 12;616(7957):504–509. doi: 10.1038/s41586-023-05923-x

Extended Data Figure 10. EBNA1-induced micronucleation of chromosome 11 includes the p-arm.

Extended Data Figure 10.

(a) Schematic of dual-colored FISH using whole chromosome 11 probe (green) and probe against 11p15 (red) on the p-arm. (b) Representative FISH images of DLD1 cells showing 11p15 on the p-arm of either intact chromosome 11’s (Day 0) or broken chromosome 11 fragments (Day 4) upon induced expression of EBNA1. (c) Representative FISH images showing that EBNA1-induced micronucleation of chromosome 11 (Day 4) includes 11p15 on the p-arm. (d) Stacked bars represent the percentage of cells with chromosome 11 micronuclei with or without 11p15. 400 cells were quantified on Day 0, 310 cells on Day 2 and 380 cells on Day 4.