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. Author manuscript; available in PMC: 2023 Oct 12.
Published in final edited form as: Nature. 2023 Apr 12;616(7957):504–509. doi: 10.1038/s41586-023-05923-x

Extended Data Figure 5. Repetitive DNA at 3q29 forms aberrant structures on mitotic chromosomes.

Extended Data Figure 5.

(a) Schematic representation of the oligo-FISH approach using a fluorescently labeled oligo (in green) to target a portion of the repeat sequence clustered at 3q29. (b) Representative oligo-FISH (c) Zoomed-in representative oligo-FISH showing normal appearance (two dots) or fragile appearance (single dot, multiple dots) on mitotic chromosomes in the indicated cell lines as quantified in (d) with or without 0.2uM aphidicolin treatment for 24 hours.