Table 1.

PK parameters of polymer and drug in tumor and plasma after a single injection of olaparib (10 mg kg⁻¹) in spherical (S) and worm-like (W) micelles (polymer/drug ratio of 10/1).

Location	Parametera)	Polymer			Drug
		Spherical	Worm	Statisticsb)	Spherical	Worm	Statisticsb)
Tumor	Tmax [h]	8.0	24.0	–	0.5	0.5	–
	Cmax [μg mL−1]	64.1	81.5	ns	2.9	1.7	**
	AUCall [h × μg mL−1]	1466.4	1638.9	ns	13.8	11.4	*
Plasma	Tmax [h]	0.5	0.5	–	0.5	0.5	–
	Cmax [μg mL−1]	1105.5	1238.9	ns	3.2	3.7	ns
	AUCall [h × μg mL−1]	7999.6	9796.0	*	14.7	14.6	ns

^a)T_max: time of the C_max; C_max: maximal observed concentration; AUC_all: area under the curve from the time of dosing to the time of the last observation;

^b)Significance S versus W groups: *p < 0.05, **p < 0.01.

See Table S4 (Supporting Information) for detailed analysis of the polymer and drug exposure and clearance.