Abstract
Haptoglobin (Hp) groups were investigated in 81 patients with motor neuron disease. A significant excess of heterozygotes was observed, accentuated among males and in the progressive spinal muscular atrophy subgroup. The results are discussed in terms of a possible influence of Hp in the immunological response.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Aspin J., Harrison R., Jehanli A., Lunt G., Campbell M. Stimulation by mitogens and neuronal membranes of lymphocytes from patients with motor neurone disease. J Neuroimmunol. 1986 Mar;11(1):31–40. doi: 10.1016/0165-5728(86)90072-x. [DOI] [PubMed] [Google Scholar]
- Baseler M. W., Burrell R. Purification of haptoglobin and its effects on lymphocyte and alveolar macrophage responses. Inflammation. 1983 Dec;7(4):387–400. doi: 10.1007/BF00916303. [DOI] [PubMed] [Google Scholar]
- Beckman L., Beckman G., Frölander N. Population studies in northern Sweden. XII. The haptoglobin polymorphism. Hum Hered. 1983;33(6):371–376. doi: 10.1159/000153405. [DOI] [PubMed] [Google Scholar]
- Bowman B. H., Kurosky A. Haptoglobin: the evolutionary product of duplication, unequal crossing over, and point mutation. Adv Hum Genet. 1982;12:189-261, 453-4. doi: 10.1007/978-1-4615-8315-8_3. [DOI] [PubMed] [Google Scholar]
- Denning-Kendall P. A., Saeed S. A., Collier H. O. Comparison of the inhibition by human serum, haptoglobin and albumin of biosynthesis of various prostaglandins. Biochem Soc Trans. 1981 Feb;9(1):93–94. doi: 10.1042/bst0090093. [DOI] [PubMed] [Google Scholar]
- Forsgren L., Almay B. G., Holmgren G., Wall S. Epidemiology of motor neuron disease in northern Sweden. Acta Neurol Scand. 1983 Jul;68(1):20–29. doi: 10.1111/j.1600-0404.1983.tb04810.x. [DOI] [PubMed] [Google Scholar]
- Garruto R. M., Gajdusek C., Chen K. M. Amyotrophic lateral sclerosis among Chamorro migrants from Guam. Ann Neurol. 1980 Dec;8(6):612–619. doi: 10.1002/ana.410080612. [DOI] [PubMed] [Google Scholar]
- Garruto R. M., Plato C. C., Myrianthopoulos N. C., Schanfield M. S., Gajdusek D. C. Blood groups, immunoglobulin allotypes and dermatoglyphic features of patients with amyotrophic lateral sclerosis and parkinsonism-dementia of Guam. Am J Med Genet. 1983 Feb;14(2):289–298. doi: 10.1002/ajmg.1320140209. [DOI] [PubMed] [Google Scholar]
- Gurney M. E., Belton A. C., Cashman N., Antel J. P. Inhibition of terminal axonal sprouting by serum from patients with amyotrophic lateral sclerosis. N Engl J Med. 1984 Oct 11;311(15):933–939. doi: 10.1056/NEJM198410113111501. [DOI] [PubMed] [Google Scholar]
- Hoffman P. M., Robbins D. S., Gibbs C. J., Jr, Gajdusek D. C., Garruto R. M., Terasaki O. I. Histocompatibility antigens in amyotrophic lateral sclerosis and parkinsonism-dementia on Guam. Lancet. 1977 Oct 1;2(8040):717–717. doi: 10.1016/s0140-6736(77)90525-6. [DOI] [PubMed] [Google Scholar]
- Kalsheker N. A., Bradwell A. R., Burnett D. The inhibition of cathepsin B by plasma haptoglobin biochemistry (enzymes, metabolism). Experientia. 1981 May 15;37(5):447–448. doi: 10.1007/BF01986123. [DOI] [PubMed] [Google Scholar]
- Mulder D. W., Kurland L. T., Offord K. P., Beard C. M. Familial adult motor neuron disease: amyotrophic lateral sclerosis. Neurology. 1986 Apr;36(4):511–517. doi: 10.1212/wnl.36.4.511. [DOI] [PubMed] [Google Scholar]
- Nevo S. S., Sutton H. E. Association between response to typhoid vaccination and known genetic markers. Am J Hum Genet. 1968 Sep;20(5):461–469. [PMC free article] [PubMed] [Google Scholar]
- Samak R., Edelstein R., Israel L. Immunosuppressive effect of acute-phase reactant proteins in vitro and its relevance to cancer. Cancer Immunol Immunother. 1982;13(1):38–43. doi: 10.1007/BF00200198. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wejman J. C., Hovsepian D., Wall J. S., Hainfeld J. F., Greer J. Structure and assembly of haptoglobin polymers by electron microscopy. J Mol Biol. 1984 Apr 5;174(2):343–368. doi: 10.1016/0022-2836(84)90342-5. [DOI] [PubMed] [Google Scholar]