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. 2023 Jun 28;9(7):e17592. doi: 10.1016/j.heliyon.2023.e17592

Fig. 3.

Fig. 3

M2-exosomes contributed to the recovery of OGD/R-induced injury in HT22 by delivering miR-124-3p. A. Co-culture of miR-124-3p mimic-exo promoted OGD/R cell proliferation. B. ROS accumulation was decreased in OGD/R-conditioned HT22 cells after co-culturing with miR-124-3p mimic-exo. C. Fe2+ concentration in OGD/R-induced HT22 cells was downregulated after co-culturing with mimic-exo. D. Mimic-exo upregulated GSH levels in OGD/R-conditioned cells. E. MDA levels in OGD/R-conditioned cells were downregulated in OGD/R-induced HT22 cells after co-culturing with miR-124-3p mimic mimic-exo. F and G. NCOA4 expressed low levels of mRNA and protein after OGD/R-conditioned cells were treated with mimic-exo. Please see Supplemental files to find uncropped pictures. *p < 0.05, **p < 0.01, ***p < 0.001 vs. control; !p < 0.05, !!p < 0.01, !!!p < 0.001 vs. vehicle.