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. 2023 Jun 28;9(7):e17592. doi: 10.1016/j.heliyon.2023.e17592

Fig. 4.

Fig. 4

NCOA4 overexpression suppressed mimic-exo function in OGD/R-conditioned HT22 cells. A and B. NCOA4 expression at the mRNA and protein levels was upregulated by NCOA4 overexpression vector (oeNCOA4) transduction. ***p < 0.001 vs. oeNC. Please see Supplemental files to find uncropped pictures. C. NCOA4 overexpression suppressed the proliferation of M2-exo-treated OGD/R cells. *p < 0.05, **p < 0.001, ***p < 0.001. D and E. ROS and Fe2+ accumulation in M2-exo-cultured OGD/R-conditioned cells was upregulated after transfecting with oeNCOA4. ***p < 0.001. F. oeNCOA4 overexpression elevated NCOA4 protein expression. Please see Supplemental files to find uncropped pictures.