Appendix Table 5. Colorectal cancers overview:

There were 16 confirmed CRCs, 10 in the HSgFOBT arm and 6 in the colonoscopy arm. Of the 10 CRCs in the FOBT arm, 6 were found through a HSgFOBT directed colonoscopy while 3 were discovered through an off-study colonoscopy. 1 subject was symptomatic and sought medical care for the symptoms prior to attempting to complete the HSgFOBT slides. 3 of the 6 CRCs in the colonoscopy arm were discovered in the baseline colonoscopy. 2 CRCs were found in a surveillance colonoscopy. One CRC was an incidental finding after a ruptured appendix in the colonoscopy arm. The annual study update questionnaires are used to ascertain any interval CRC’s.

a. Cancers found by year and study arm.

	Screening-Colonoscopy Arm			HSgFOBT Arm
Study Year	Baseline Colonoscopy	Follow-up Colonoscopy	Other	HSgFOBT + Directed Colonoscopy	Crossover Colonoscopy	Other
Year 0	3	0	1*	1	1	1†
Year 1	0	0	0	2	2	0
Year 2	0	0	0	0	0	0
Year 3	0	1	0	1	0	0
Year 4	0	0	0	1	0	0
Year 5	0	1	0	1	0	0
Total	3	2	1	6	3	1

High sensitivity fecal occult blood test (HSgFOBT)

^*CRC found through hospital surgery/laparoscopy for raptured appendix

^†CRC found through barium enema