Appendix Table 6.

Pathology outcomes of participants with one or more first-degree relatives with colorectal cancer

	No FDRs N (%)	1 FDR N (%)	2 or more FDRs N (%)	All patients
Sample Size	2816 (90.5%)	276 (8.9%)	21 (0.7%)	3523
Randomization Arm
Screening-colonoscopy	1445 (51.3%)	149 (54.0%)	13 (61.9%)	1761
HSgFOBT	1371 (48.7%)	127 (46.0%)	8 (38.1%)	1762
Pathology Findings
Cancer*	13 (0.5%)	2 (0.7%)	0	16 (0.5%)
Advanced Neoplasia	189 (6.7%)	21 (7.6%)	0	232 (6.63%)

First-degree relative (FDR)

^*One additional participant who had CRC did not disclose family history questionnaire