Pathophysiology of nighttime noise-induced arterial hypertension. Genetic Nox2 deficiency and pharmacological FOXO3 activation by bepridil prevented the adverse noise effects. 3-NT, 3-nitrotyrosine; CD68, macrosialin; eNOS, endothelial nitric oxide synthase; HPA, hypothalamic pituitary adrenal; IL-6, interleukin 6; iNOS, inducible nitric oxide synthase; MCP-1, monocyte chemoattractant protein-1; MDA, malondialdehyde. Figure adapted from reference 70 with permission.