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. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: Hypertension. 2023 Apr 19;80(7):1384–1392. doi: 10.1161/HYPERTENSIONAHA.123.20617

Figure 2.

Figure 2.

Pathophysiology of nighttime noise-induced arterial hypertension. Genetic Nox2 deficiency and pharmacological FOXO3 activation by bepridil prevented the adverse noise effects. 3-NT, 3-nitrotyrosine; CD68, macrosialin; eNOS, endothelial nitric oxide synthase; HPA, hypothalamic pituitary adrenal; IL-6, interleukin 6; iNOS, inducible nitric oxide synthase; MCP-1, monocyte chemoattractant protein-1; MDA, malondialdehyde. Figure adapted from reference 70 with permission.