Skip to main content
NCBI home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1988 Sep;51(9):1120–1125. doi: 10.1136/jnnp.51.9.1120

Auditory long latency event-related potentials in Alzheimer's disease and multi-infarct dementia.

R Neshige 1, G Barrett 1, H Shibasaki 1
PMCID: PMC1033013  PMID: 3225596

Abstract

An auditory discrimination paradigm was employed to elicit event-related brain potentials in 13 patients with Alzheimer's disease and 14 patients with multi-infarct dementia. The P300 latency was significantly prolonged in 12 patients with dementia compared with age-matched controls and showed a significant negative correlation with the score of Wechsler Adult Intelligence Scale (WAIS), especially with that of Digit Span subtest. There was no disease specificity. After physostigmine treatment, P300 latency decreased and WAIS score increased in 6 among 10 cases.

Full text

PDF
1120

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barrett G., Neshige R., Shibasaki H. Human auditory and somatosensory event-related potentials: effects of response condition and age. Electroencephalogr Clin Neurophysiol. 1987 Apr;66(4):409–419. doi: 10.1016/0013-4694(87)90210-0. [DOI] [PubMed] [Google Scholar]
  2. Brown W. S., Marsh J. T., LaRue A. Event-related potentials in psychiatry: differentiating depression and dementia in the elderly. Bull Los Angeles Neurol Soc. 1982;47:91–107. [PubMed] [Google Scholar]
  3. Canter N. L., Hallett M., Growdon J. H. Lecithin does not affect EEG spectral analysis or P300 in Alzheimer disease. Neurology. 1982 Nov;32(11):1260–1266. doi: 10.1212/wnl.32.11.1260. [DOI] [PubMed] [Google Scholar]
  4. Etienne P., Gauthier S., Johnson G., Collier B., Mendis T., Dastoor D., Cole M., Muller H. F. Clinical effects of choline in Alzheimer's disease. Lancet. 1978 Mar 4;1(8062):508–509. doi: 10.1016/s0140-6736(78)90180-0. [DOI] [PubMed] [Google Scholar]
  5. Goodin D. S., Squires K. C., Henderson B. H., Starr A. Age-related variations in evoked potentials to auditory stimuli in normal human subjects. Electroencephalogr Clin Neurophysiol. 1978 Apr;44(4):447–458. doi: 10.1016/0013-4694(78)90029-9. [DOI] [PubMed] [Google Scholar]
  6. Goodin D. S., Squires K. C., Starr A. Variations in early and late event-related components of the auditory evoked potential with task difficulty. Electroencephalogr Clin Neurophysiol. 1983 Jun;55(6):680–686. doi: 10.1016/0013-4694(83)90278-x. [DOI] [PubMed] [Google Scholar]
  7. Hachinski V. C., Iliff L. D., Zilhka E., Du Boulay G. H., McAllister V. L., Marshall J., Russell R. W., Symon L. Cerebral blood flow in dementia. Arch Neurol. 1975 Sep;32(9):632–637. doi: 10.1001/archneur.1975.00490510088009. [DOI] [PubMed] [Google Scholar]
  8. Halgren E., Squires N. K., Wilson C. L., Rohrbaugh J. W., Babb T. L., Crandall P. H. Endogenous potentials generated in the human hippocampal formation and amygdala by infrequent events. Science. 1980 Nov 14;210(4471):803–805. doi: 10.1126/science.7434000. [DOI] [PubMed] [Google Scholar]
  9. Hansch E. C., Syndulko K., Cohen S. N., Goldberg Z. I., Potvin A. R., Tourtellotte W. W. Cognition in Parkinson disease: an event-related potential perspective. Ann Neurol. 1982 Jun;11(6):599–607. doi: 10.1002/ana.410110608. [DOI] [PubMed] [Google Scholar]
  10. Hömberg V., Hefter H., Granseyer G., Strauss W., Lange H., Hennerici M. Event-related potentials in patients with Huntington's disease and relatives at risk in relation to detailed psychometry. Electroencephalogr Clin Neurophysiol. 1986 Jun;63(6):552–569. doi: 10.1016/0013-4694(86)90143-4. [DOI] [PubMed] [Google Scholar]
  11. Kutas M., McCarthy G., Donchin E. Augmenting mental chronometry: the P300 as a measure of stimulus evaluation time. Science. 1977 Aug 19;197(4305):792–795. doi: 10.1126/science.887923. [DOI] [PubMed] [Google Scholar]
  12. McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E. M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984 Jul;34(7):939–944. doi: 10.1212/wnl.34.7.939. [DOI] [PubMed] [Google Scholar]
  13. Mullen K. T., Plant G. T. Colour and luminance vision in human optic neuritis. Brain. 1986 Feb;109(Pt 1):1–13. doi: 10.1093/brain/109.1.1. [DOI] [PubMed] [Google Scholar]
  14. Okada Y. C., Kaufman L., Williamson S. J. The hippocampal formation as a source of the slow endogenous potentials. Electroencephalogr Clin Neurophysiol. 1983 Apr;55(4):417–426. doi: 10.1016/0013-4694(83)90130-x. [DOI] [PubMed] [Google Scholar]
  15. Pfefferbaum A., Ford J. M., Wenegrat B. G., Roth W. T., Kopell B. S. Clinical application of the P3 component of event-related potentials. I. Normal aging. Electroencephalogr Clin Neurophysiol. 1984 Apr;59(2):85–103. doi: 10.1016/0168-5597(84)90026-1. [DOI] [PubMed] [Google Scholar]
  16. Pfefferbaum A., Wenegrat B. G., Ford J. M., Roth W. T., Kopell B. S. Clinical application of the P3 component of event-related potentials. II. Dementia, depression and schizophrenia. Electroencephalogr Clin Neurophysiol. 1984 Apr;59(2):104–124. doi: 10.1016/0168-5597(84)90027-3. [DOI] [PubMed] [Google Scholar]
  17. Picton T. W., Stuss D. T., Champagne S. C., Nelson R. F. The effects of age on human event-related potentials. Psychophysiology. 1984 May;21(3):312–325. doi: 10.1111/j.1469-8986.1984.tb02941.x. [DOI] [PubMed] [Google Scholar]
  18. Polich J., Howard L., Starr A. P300 latency correlates with digit span. Psychophysiology. 1983 Nov;20(6):665–669. doi: 10.1111/j.1469-8986.1983.tb00936.x. [DOI] [PubMed] [Google Scholar]
  19. Ritter W., Simson R., Vaughan H. G., Jr, Friedman D. A brain event related to the making of a sensory discrimination. Science. 1979 Mar 30;203(4387):1358–1361. doi: 10.1126/science.424760. [DOI] [PubMed] [Google Scholar]
  20. Signoret J. L., Whiteley A., Lhermitte F. Influence of choline on amnesia in early Alzheimer's disease. Lancet. 1978 Oct 14;2(8094):837–837. doi: 10.1016/s0140-6736(78)92612-0. [DOI] [PubMed] [Google Scholar]
  21. Squires K. C., Squires N. K., Hillyard S. A. Decision-related cortical potentials during an auditory signal detection task with cued observation intervals. J Exp Psychol Hum Percept Perform. 1975 Aug;1(3):268–279. doi: 10.1037//0096-1523.1.3.268. [DOI] [PubMed] [Google Scholar]
  22. Sutton S., Braren M., Zubin J., John E. R. Evoked-potential correlates of stimulus uncertainty. Science. 1965 Nov 26;150(3700):1187–1188. doi: 10.1126/science.150.3700.1187. [DOI] [PubMed] [Google Scholar]
  23. Syndulko K., Hansch E. C., Cohen S. N., Pearce J. W., Goldberg Z., Montan B., Tourtellotte W. W., Potvin A. R. Long-latency event-related potentials in normal aging and dementia. Adv Neurol. 1982;32:279–285. [PubMed] [Google Scholar]
  24. Thal L. J., Fuld P. A., Masur D. M., Sharpless N. S. Oral physostigmine and lecithin improve memory in Alzheimer disease. Ann Neurol. 1983 May;13(5):491–496. doi: 10.1002/ana.410130504. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES