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. 1988 Sep;51(9):1164–1170. doi: 10.1136/jnnp.51.9.1164

The conduction velocities of peripheral nerve fibres conveying sensations of warming and cooling.

C J Fowler 1, K Sitzoglou 1, Z Ali 1, P Halonen 1
PMCID: PMC1033021  PMID: 3225599

Abstract

With the current practice of measuring thresholds for warming and cooling separately, the question of the exact nature of afferents subserving these sensations assumes new importance. Experiments to measure reaction times to warming and cooling stimuli at two sites on the lower limb are described. The conduction velocity for each sensation was estimated from the conduction distance and conduction time in the limb. The estimated mean conduction velocity for warming was 0.5, SD 0.2 m/s and cooling 2.1, SD 0.8 m/s. These figures confirm that the sensation of warming is conveyed in unmyelinated and cooling in small myelinated peripheral nerve fibres.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adriaensen H., Gybels J., Handwerker H. O., Van Hees J. Response properties of thin myelinated (A-delta) fibers in human skin nerves. J Neurophysiol. 1983 Jan;49(1):111–122. doi: 10.1152/jn.1983.49.1.111. [DOI] [PubMed] [Google Scholar]
  2. Arezzo J. C., Schaumburg H. H., Laudadio C. Thermal sensitivity tester. Device for quantitative assessment of thermal sense in diabetic neuropathy. Diabetes. 1986 May;35(5):590–592. doi: 10.2337/diab.35.5.590. [DOI] [PubMed] [Google Scholar]
  3. Bazett H. C., McGlone B., Brocklehurst R. J. The temperatures in the tissues which accompany temperature sensations. J Physiol. 1930 Mar 17;69(1):88–112. doi: 10.1113/jphysiol.1930.sp002637. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Behse F., Buchthal F. Normal sensory conduction in the nerves of the leg in man. J Neurol Neurosurg Psychiatry. 1971 Aug;34(4):404–414. doi: 10.1136/jnnp.34.4.404. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Bertelsmann F. W., Heimans J. J., Weber E. J., van der Veen E. A., Schouten J. A. Thermal discrimination thresholds in normal subjects and in patients with diabetic neuropathy. J Neurol Neurosurg Psychiatry. 1985 Jul;48(7):686–690. doi: 10.1136/jnnp.48.7.686. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bessou P., Perl E. R. Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli. J Neurophysiol. 1969 Nov;32(6):1025–1043. doi: 10.1152/jn.1969.32.6.1025. [DOI] [PubMed] [Google Scholar]
  7. Chatt A. B., Kenshalo D. R. Cerebral evoked responses to skin warming recorded from human scalp. Exp Brain Res. 1977 Jul 15;28(5):449–455. doi: 10.1007/BF00236469. [DOI] [PubMed] [Google Scholar]
  8. Darian-Smith I., Johnson K. O., Dykes R. "Cold" fiber population innervating palmar and digital skin of the monkey: responses to cooling pulses. J Neurophysiol. 1973 Mar;36(2):325–346. doi: 10.1152/jn.1973.36.2.325. [DOI] [PubMed] [Google Scholar]
  9. Darian-Smith I., Johnson K. O., LaMotte C., Shigenaga Y., Kenins P., Champness P. Warm fibers innervating palmar and digital skin of the monkey: responses to thermal stimuli. J Neurophysiol. 1979 Sep;42(5):1297–1315. doi: 10.1152/jn.1979.42.5.1297. [DOI] [PubMed] [Google Scholar]
  10. Duclaux R., Franzen O., Chatt A. B., Kenshalo D. R., Stowell H. Responses recorded from human scalp evoked by cutaneous thermal stimulation. Brain Res. 1974 Sep 27;78(2):279–290. doi: 10.1016/0006-8993(74)90552-6. [DOI] [PubMed] [Google Scholar]
  11. Duclaux R., Kenshalo D. R., Sr Response characteristics of cutaneous warm receptors in the monkey. J Neurophysiol. 1980 Jan;43(1):1–15. doi: 10.1152/jn.1980.43.1.1. [DOI] [PubMed] [Google Scholar]
  12. Dyck P. J., Zimmerman I. R., O'Brien P. C., Ness A., Caskey P. E., Karnes J., Bushek W. Introduction of automated systems to evaluate touch-pressure, vibration, and thermal cutaneous sensation in man. Ann Neurol. 1978 Dec;4(6):502–510. doi: 10.1002/ana.410040605. [DOI] [PubMed] [Google Scholar]
  13. EMMELIN N., ENGSTROM J. On the existence of specific secretory sympathetic fibres for the cat's submaxillary gland. J Physiol. 1960 Aug;153:1–8. doi: 10.1113/jphysiol.1960.sp006514. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Ford D. J., Raj P. P., Singh P., Regan K. M., Ohlweiler D. Differential peripheral nerve block by local anesthetics in the cat. Anesthesiology. 1984 Jan;60(1):28–33. doi: 10.1097/00000542-198401000-00007. [DOI] [PubMed] [Google Scholar]
  15. Franz D. N., Perry R. S. Mechanisms for differential block among single myelinated and non-myelinated axons by procaine. J Physiol. 1974 Jan;236(1):193–210. doi: 10.1113/jphysiol.1974.sp010430. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Fruhstorfer H., Lindblom U., Schmidt W. C. Method for quantitative estimation of thermal thresholds in patients. J Neurol Neurosurg Psychiatry. 1976 Nov;39(11):1071–1075. doi: 10.1136/jnnp.39.11.1071. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Fruhstorfer H., Zenz M., Nolte H., Hensel H. Dissociated loss of cold and warm sensibility during regional anaesthesia. Pflugers Arch. 1974 May 24;349(1):73–82. doi: 10.1007/BF00587918. [DOI] [PubMed] [Google Scholar]
  18. Gissen A. J., Covino B. G., Gregus J. Differential sensitivities of mammalian nerve fibers to local anesthetic agents. Anesthesiology. 1980 Dec;53(6):467–474. doi: 10.1097/00000542-198012000-00006. [DOI] [PubMed] [Google Scholar]
  19. Hallin R. G., Torebjörk H. E., Wiesenfeld Z. Nociceptors and warm receptors innervated by C fibres in human skin. J Neurol Neurosurg Psychiatry. 1982 Apr;45(4):313–319. doi: 10.1136/jnnp.45.4.313. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Hensel H., Iggo A. Analysis of cutaneous warm and cold fibres in primates. Pflugers Arch. 1971;329(1):1–8. doi: 10.1007/BF00586896. [DOI] [PubMed] [Google Scholar]
  21. IRIUCHIJIMA J., ZOTTERMAN Y. The specificity of afferent cutaneous C fibres in mammals. Acta Physiol Scand. 1960 Jul 15;49:267–278. doi: 10.1111/j.1748-1716.1960.tb01952.x. [DOI] [PubMed] [Google Scholar]
  22. Iggo A. Cutaneous thermoreceptors in primates and sub-primates. J Physiol. 1969 Feb;200(2):403–430. doi: 10.1113/jphysiol.1969.sp008701. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Jacobs J. M., Love S. Qualitative and quantitative morphology of human sural nerve at different ages. Brain. 1985 Dec;108(Pt 4):897–924. doi: 10.1093/brain/108.4.897. [DOI] [PubMed] [Google Scholar]
  24. Jamal G. A., Hansen S., Weir A. I., Ballantyne J. P. An improved automated method for the measurement of thermal thresholds. 1. Normal subjects. J Neurol Neurosurg Psychiatry. 1985 Apr;48(4):354–360. doi: 10.1136/jnnp.48.4.354. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Konietzny F., Hensel H. Letters and notes: Warm fiber activity in human skin nerves. Pflugers Arch. 1975 Sep 9;359(3):265–267. doi: 10.1007/BF00587384. [DOI] [PubMed] [Google Scholar]
  26. Konietzny F., Hensel H. The dynamic response of warm units in human skin nerves. Pflugers Arch. 1977 Jul 29;370(1):111–114. doi: 10.1007/BF00707956. [DOI] [PubMed] [Google Scholar]
  27. LELE P. P., SINCLAIR D. C. Observations on the reaction time to cutaneous thermal stimuli. J Neurol Neurosurg Psychiatry. 1955 May;18(2):120–124. doi: 10.1136/jnnp.18.2.120. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Mackenzie R. A., Burke D., Skuse N. F., Lethlean A. K. Fibre function and perception during cutaneous nerve block. J Neurol Neurosurg Psychiatry. 1975 Sep;38(9):865–873. doi: 10.1136/jnnp.38.9.865. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. NATHAN P. W., SEARS T. A. Some factors concerned in differential nerve block by local anaesthetics. J Physiol. 1961 Aug;157:565–580. doi: 10.1113/jphysiol.1961.sp006743. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Ochoa J., Mair W. G. The normal sural nerve in man. I. Ultrastructure and numbers of fibres and cells. Acta Neuropathol. 1969;13(3):197–216. doi: 10.1007/BF00690642. [DOI] [PubMed] [Google Scholar]
  31. Perl E. R. Myelinated afferent fibres innervating the primate skin and their response to noxious stimuli. J Physiol. 1968 Aug;197(3):593–615. doi: 10.1113/jphysiol.1968.sp008576. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Sumino R., Dubner R., Starkman S. Responses of small myelinated "warm" fibers to noxious heat stimuli applied to the monkey's face. Brain Res. 1973 Nov 9;62(1):260–263. doi: 10.1016/0006-8993(73)90638-0. [DOI] [PubMed] [Google Scholar]
  33. Torebjörk H. E., Hallin R. G. Identification of afferent C units in intact human skin nerves. Brain Res. 1974 Mar 8;67(3):387–403. doi: 10.1016/0006-8993(74)90489-2. [DOI] [PubMed] [Google Scholar]
  34. Torebjörk H. E., Hallin R. G. Perceptual changes accompanying controlled preferential blocking of A and C fibre responses in intact human skin nerves. Exp Brain Res. 1973 Jan 29;16(3):321–332. doi: 10.1007/BF00233334. [DOI] [PubMed] [Google Scholar]
  35. Vallbo A. B., Hagbarth K. E., Torebjörk H. E., Wallin B. G. Somatosensory, proprioceptive, and sympathetic activity in human peripheral nerves. Physiol Rev. 1979 Oct;59(4):919–957. doi: 10.1152/physrev.1979.59.4.919. [DOI] [PubMed] [Google Scholar]
  36. WRIGHT G. H. The latency of sensations of warmth due to radiation. J Physiol. 1951 Feb;112(3-4):344–358. doi: 10.1113/jphysiol.1951.sp004533. [DOI] [PMC free article] [PubMed] [Google Scholar]

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