Abstract
Two cases of familial myasthenia gravis are reported. One patient is a typical case of autoimmune myasthenia with positive anti acetylcholine receptor antibodies, while in the second patient the impairment of neuromuscular transmission is likely to be due to antibodies directed against determinants other than the acetylcholine receptors.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bartoccioni E., Scuderi F., Scoppetta C., Evoli A., Tonali P., Guidi L., Bartoloni C., Terranova T. Myasthenia gravis, thymectomy, and antiacetycholine receptor antibody. J Neurol. 1980;224(1):9–15. doi: 10.1007/BF00313202. [DOI] [PubMed] [Google Scholar]
- Besinger U. A., Toyka K. V., Hömberg M., Heininger K., Hohlfeld R., Fateh-Moghadam A. Myasthenia gravis: long-term correlation of binding and bungarotoxin blocking antibodies against acetylcholine receptors with changes in disease severity. Neurology. 1983 Oct;33(10):1316–1321. doi: 10.1212/wnl.33.10.1316. [DOI] [PubMed] [Google Scholar]
- Compston D. A., Vincent A., Newsom-Davis J., Batchelor J. R. Clinical, pathological, HLA antigen and immunological evidence for disease heterogeneity in myasthenia gravis. Brain. 1980 Sep;103(3):579–601. doi: 10.1093/brain/103.3.579. [DOI] [PubMed] [Google Scholar]
- Engel A. G. Myasthenia gravis and myasthenic syndromes. Ann Neurol. 1984 Nov;16(5):519–534. doi: 10.1002/ana.410160502. [DOI] [PubMed] [Google Scholar]
- Lindstrom J. M., Seybold M. E., Lennon V. A., Whittingham S., Duane D. D. Antibody to acetylcholine receptor in myasthenia gravis. Prevalence, clinical correlates, and diagnostic value. Neurology. 1976 Nov;26(11):1054–1059. doi: 10.1212/wnl.26.11.1054. [DOI] [PubMed] [Google Scholar]
- Lindstrom J. An assay for antibodies to human acetylcholine receptor in serum from patients with myasthenia gravis. Clin Immunol Immunopathol. 1977 Jan;7(1):36–43. doi: 10.1016/0090-1229(77)90027-7. [DOI] [PubMed] [Google Scholar]
- Mossman S., Vincent A., Newsom-Davis J. Myasthenia gravis without acetylcholine-receptor antibody: a distinct disease entity. Lancet. 1986 Jan 18;1(8473):116–119. doi: 10.1016/s0140-6736(86)92259-2. [DOI] [PubMed] [Google Scholar]
- Namba T., Brunner N. G., Brown S. B., Muguruma M., Grob D. Familial myasthenia gravis. Report of 27 patients in 12 families and review of 164 patients in 73 families. Arch Neurol. 1971 Jul;25(1):49–60. doi: 10.1001/archneur.1971.00490010059009. [DOI] [PubMed] [Google Scholar]
- Newsom-Davis J., Willcox N., Schluep M., Harcourt G., Vincent A., Mossman S., Wray D., Burges J. Immunological heterogeneity and cellular mechanisms in myasthenia gravis. Ann N Y Acad Sci. 1987;505:12–26. doi: 10.1111/j.1749-6632.1987.tb51279.x. [DOI] [PubMed] [Google Scholar]
- Vincent A., Newsom Davis J. Anti-acetylcholine receptor antibodies. J Neurol Neurosurg Psychiatry. 1980 Jul;43(7):590–600. doi: 10.1136/jnnp.43.7.590. [DOI] [PMC free article] [PubMed] [Google Scholar]