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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1988 May;51(5):646–650. doi: 10.1136/jnnp.51.5.646

Primary brainstem death: a clinico-pathological study.

J Ogata 1, M Imakita 1, C Yutani 1, S Miyamoto 1, H Kikuchi 1
PMCID: PMC1033070  PMID: 3404164

Abstract

A case of primary brainstem death in a man with surgically treated cerebellar haemorrhage is reported. Necropsy revealed extensive necrosis confined to the brainstem and cerebellum. The absence of diabetes insipidus and the persistence of electroencephalographic activity were the characteristic clinical features of the case. This differentiates the condition from so-called "whole brain death". Analysis of three further cases with acute vascular lesions of the brainstem or cerebellum, shown at necropsy, revealed that primary brainstem death with prolonged somatic survival can occur in specific circumstances after surgical intervension.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chase T. N., Moretti L., Prensky A. L. Clinical and electroencephalographic manifestations of vascular lesions of the pons. Neurology. 1968 Apr;18(4):357–368. doi: 10.1212/wnl.18.4.357. [DOI] [PubMed] [Google Scholar]
  2. Darby J., Yonas H., Brenner R. P. Brainstem death with persistent EEG activity: evaluation by xenon-enhanced computed tomography. Crit Care Med. 1987 May;15(5):519–521. doi: 10.1097/00003246-198705000-00014. [DOI] [PubMed] [Google Scholar]
  3. Ferbert A., Buchner H., Ringelstein E. B., Hacke W. Isolated brain-stem death. Case report with demonstration of preserved visual evoked potentials (VEPs). Electroencephalogr Clin Neurophysiol. 1986 Mar;65(2):157–160. doi: 10.1016/0168-5597(86)90049-3. [DOI] [PubMed] [Google Scholar]
  4. Ogata J., Yutani C., Imakita M., Ueda H., Waki R., Ogawa M., Yamaguchi T., Sawada T., Kikuchi H. Autolysis of the granular layer of the cerebellar cortex in brain death. Acta Neuropathol. 1986;70(1):75–78. doi: 10.1007/BF00689517. [DOI] [PubMed] [Google Scholar]
  5. Pallis C. ABC of brain stem death. From brain death to brain stem death. Br Med J (Clin Res Ed) 1982 Nov 20;285(6353):1487–1490. doi: 10.1136/bmj.285.6353.1487. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Pallis C. Diabetes insipidus with brain death. Neurology. 1985 Jul;35(7):1086–1087. doi: 10.1212/wnl.35.7.1086-a. [DOI] [PubMed] [Google Scholar]
  7. Pearson J., Korein J., Harris J. H., Wichter M., Braunstein P. Brain death: II. Neuropathological correlation with the radioisotopic bolus technique for evaluation of critical deficit of cerebral blood flow. Ann Neurol. 1977 Sep;2(3):206–210. doi: 10.1002/ana.410020305. [DOI] [PubMed] [Google Scholar]
  8. Takeuchi K., Takeshita H., Takakura K., Shimazono Y., Handa H., Gotoh F., Manaka S., Shiogai T. Evolution of criteria for determination of brain death in Japan. Acta Neurochir (Wien) 1987;87(3-4):93–98. doi: 10.1007/BF01476058. [DOI] [PubMed] [Google Scholar]

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