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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1988 May;51(5):671–676. doi: 10.1136/jnnp.51.5.671

Short-term stability of single motor unit recordings in motor neuron disease: a macro EMG study.

R J Guiloff 1, H Modarres-Sadeghi 1, E Stålberg 1, H Rogers 1
PMCID: PMC1033073  PMID: 3136230

Abstract

Thirty five individual macro EMG motor unit potentials in 13 patients with motor neuron disease were recorded every 15 minutes during a 2 hour period. No significant change in amplitude or area was seen in 15 control units in nine patients or in 20 units in 11 patients receiving RX77368 0.2-0.3 mg/kg. The findings provide no evidence for an action of this long acting TRH analogue on the peripheral territory of motor units in motor neuron disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Clarke K. A., Parker A. J., Stirk G. C. Motoneurone excitability during antidromically evoked inhibition after administration of a thyrotrophin releasing hormone (TRH) analogue. Neuropeptides. 1984 Sep;4(5):403–411. doi: 10.1016/0143-4179(84)90115-x. [DOI] [PubMed] [Google Scholar]
  2. Clarke K. A., Stirk G. Motoneurone excitability after administration of a thyrotrophin releasing hormone analogue. Br J Pharmacol. 1983 Nov;80(3):561–565. doi: 10.1111/j.1476-5381.1983.tb10729.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cooper B. R., Boyer C. E. Stimulant action of thyrotropin releasing hormone on cat spinal cord. Neuropharmacology. 1978 Feb;17(2):153–156. doi: 10.1016/0028-3908(78)90128-4. [DOI] [PubMed] [Google Scholar]
  4. Delwaide P. J., Schoenen J. The effect of TRH on F waves recorded from antagonistic muscles in human subjects. Ann Neurol. 1985 Sep;18(3):366–367. doi: 10.1002/ana.410180321. [DOI] [PubMed] [Google Scholar]
  5. Engel W. K., Siddique T., Nicoloff J. T. Effect on weakness and spasticity in amyotrophic lateral sclerosis of thyrotropin-releasing hormone. Lancet. 1983 Jul 9;2(8341):73–75. doi: 10.1016/s0140-6736(83)90060-0. [DOI] [PubMed] [Google Scholar]
  6. Guiloff R. J., Eckland D. J., Demaine C., Hoare R. C., MacRae K. D., Lightman S. L. Controlled acute trial of a thyrotrophin releasing hormone analogue (RX77368) in motor neuron disease. J Neurol Neurosurg Psychiatry. 1987 Oct;50(10):1359–1370. doi: 10.1136/jnnp.50.10.1359. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Guiloff R. J., Stålberg E., Eckland D. J., Lightman S. L. Electrophysiological observations in patients with motor neuron disease receiving a thyrotropin releasing hormone analogue (RX77368). J Neurol Neurosurg Psychiatry. 1987 Dec;50(12):1633–1640. doi: 10.1136/jnnp.50.12.1633. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Nicoll R. A. Excitatory action of TRH on spinal motoneurones. Nature. 1977 Jan 20;265(5591):242–243. doi: 10.1038/265242a0. [DOI] [PubMed] [Google Scholar]
  9. Nicoll R. A. The action of thyrotropin-releasing hormone, substance P and related peptides on frog spinal motoneurons. J Pharmacol Exp Ther. 1978 Dec;207(3):817–824. [PubMed] [Google Scholar]
  10. Ono H., Fukuda H. Ventral root depolarization and spinal reflex augmentation by a TRH analog in rat spinal cord. Neuropharmacology. 1982 Aug;21(8):739–744. doi: 10.1016/0028-3908(82)90058-2. [DOI] [PubMed] [Google Scholar]
  11. Pawłowski L., Ruczyńska J., Przegaliński E. The effect of thyroliberin and some of its analogues on the hind limb flexor reflex in the spinal rat. Pol J Pharmacol Pharm. 1980 Jul-Aug;32(4):539–550. [PubMed] [Google Scholar]
  12. Phillis J. W., Kirkpatrick J. R. Actions of various gastrointestinal peptides on the isolated amphibian spinal cord. Can J Physiol Pharmacol. 1979 Aug;57(8):887–899. doi: 10.1139/y79-136. [DOI] [PubMed] [Google Scholar]
  13. Stålberg E., Fawcett P. R. Macro EMG in healthy subjects of different ages. J Neurol Neurosurg Psychiatry. 1982 Oct;45(10):870–878. doi: 10.1136/jnnp.45.10.870. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Stålberg E. Macro EMG, a new recording technique. J Neurol Neurosurg Psychiatry. 1980 Jun;43(6):475–482. doi: 10.1136/jnnp.43.6.475. [DOI] [PMC free article] [PubMed] [Google Scholar]

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